Alvin Shrier, McGill University

Research

Long Qt Syndrome Quality Control Channel Internalization And Degradation Channel Stoichiometry Herg Potassium Channel Patch Clamp Pharmacology Eletrophysiology

Latest papers

Phase resetting in human stem cell derived cardiomyocytes explains complex cardiac arrhythmias.
PLoS computational biology · 2026
Dependence of premature ventricular complexes on heart rate-it's not that simple.
Journal of the American Medical Informatics Association : JAMIA · 2026
Predicting discrete-time bifurcations with deep learning.
Nature communications · 2023

All 42 publications

Latest funding

Characterization of hERG mutant cardiomyocytes derived from human pluripotent stem cells
CIHR · 2025 · Supervisor
$6,000
Quality control and pharmacological rescue of heteromeric long QT mutants
CIHR · 2019 · Nominated PI
$768,825
Molecular Mechanisms of hERG Quality Control
CIHR · 2013 · Nominated PI
$613,220

All 8 grants and awards

42 publications.

01

Phase resetting in human stem cell derived cardiomyocytes explains complex cardiac arrhythmias.

Diagne K, Bury TM, Pettebone ME, Deyell MW, Laksman Z, Shrier A, Glass L, Bub G, Entcheva E

PLoS computational biology2026

DOI: 10.1371/journal.pcbi.1013935 PMID: 41637430

02

Dependence of premature ventricular complexes on heart rate-it's not that simple.

Osakwe A, Wightman N, Deyell MW, Laksman Z, Shrier A, Bub G, Glass L, Bury TM

Journal of the American Medical Informatics Association : JAMIA2026

DOI: 10.1093/jamia/ocaf069 PMID: 40354591

03

Predicting discrete-time bifurcations with deep learning.

Bury TM, Dylewsky D, Bauch CT, Anand M, Glass L, Shrier A, Bub G

Nature communications2023

DOI: 10.1038/s41467-023-42020-z PMID: 37816722

04

Rhythms from Two Competing Periodic Sources Embedded in an Excitable Medium.

Diagne K, Bury TM, Deyell MW, Laksman Z, Shrier A, Bub G, Glass L

Physical review letters2023

DOI: 10.1103/physrevlett.130.028401 PMID: 36706395

05

KHz-rate volumetric voltage imaging of the whole Zebrafish heart.

Sacconi L, Silvestri L, Rodríguez EC, Armstrong GAB, Pavone FS, Shrier A, Bub G

Biophysical reports2022

DOI: 10.1016/j.bpr.2022.100046 PMID: 36425080

06

Universal mechanisms for self-termination of rapid cardiac rhythm.

Biasci V, Sacconi L, Cytrynbaum EN, Pijnappels DA, De Coster T, Shrier A, Glass L, Bub G

Chaos (Woodbury, N.Y.)2020

DOI: 10.1063/5.0033813 PMID: 33380016

07

High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants.

Ng CA, Perry MD, Liang W, Smith NJ, Foo B, Shrier A, Lukacs GL, Hill AP, Vandenberg JI

Heart rhythm2020

DOI: 10.1016/j.hrthm.2019.09.020 PMID: 31557540

08

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block.

Tomek J, Bueno-Orovio A, Passini E, Zhou X, Minchole A, Britton O, Bartolucci C, Severi S, Shrier A, Virag L, Varro A, Rodriguez B

eLife2019

DOI: 10.7554/elife.48890 PMID: 31868580

09

Hsp70 and DNAJA2 limit CFTR levels through degradation.

Kim Chiaw P, Hantouche C, Wong MJH, Matthes E, Robert R, Hanrahan JW, Shrier A, Young JC

PloS one2019

DOI: 10.1371/journal.pone.0220984 PMID: 31408507

10

Double-wave reentry in excitable media.

Cytrynbaum EN, MacKay V, Nahman-Lévesque O, Dobbs M, Bub G, Shrier A, Glass L

Chaos (Woodbury, N.Y.)2019

DOI: 10.1063/1.5092982 PMID: 31370409

Characterization of hERG mutant cardiomyocytes derived from human pluripotent stem cells

SupervisorCIHR2025Undergraduate Student Research Awards (USRA)

Principal investigators: Gaspard, Fedgi Dony

Keywords: Arrhythmias; Cell Lines; Gene; Genetically Modified; Human Cardiac Cells; Mutants; Mutations; Qt Syndrome

$6,000

Quality control and pharmacological rescue of heteromeric long QT mutants

Nominated PICIHR2019Project Grant

Principal investigators: Shrier, Alvin

Keywords: Channel Internalization And Degradation; Channel Stoichiometry; Herg Potassium Channel; Long Qt Syndrome; Patch Clamp; Pharmacology; Quality Control

$768,825

Molecular Mechanisms of hERG Quality Control

Nominated PICIHR2013Operating Grant

Principal investigators: Shrier, Alvin

Keywords: Eletrophysiology; Endocytosis; Herg Channel; Long Qt Syndrome; Quality Control; Trafficking

$613,220

Molecular mechanisms of Long-QT Syndrome Type-2 caused by cell surface destabilization of hERG

SupervisorCIHR2013Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Foo, Brian

Keywords: Herg K+ Channel; Inheritable Diseases; Long Qt Syndrome Type 2; Plasma Membrane; Protein Quality Control; Protein Trafficking; Protein Unfolding; Proteomics; Ubiquitination

$105,000

Mathematics of Information Technology and Complex Systems/Les mathématiques des technologies de l'information et des systèmes complexes

Co-investigatorNSERC2009Networks of Centres of Excellence

Principal investigators: Gupta, Arvind

$12,553,000

CIHR Training Program in Integrative Approaches to Human Health

Co-investigatorCIHR2008Training Grant

Principal investigators: Hallett, Michael T

Keywords: Bioinformatics; Cancer; Complex Diseases; Computational Biology; Genomics; Imaging; Mathematical Modelling; Orphan Diseases; Proteomics; Quantitative Biology; Systems Biology

$1,766,127

Micromachining facility access

Co-investigatorNSERC2006Major Facilities Access Grants

Principal investigators: Kirk, Andrew

$60,450

Mathematics of Information Technology and Complex Systems (MITACS)

Co-investigatorNSERC2005Networks of Centres of Excellence

Principal investigators: Gupta, Arvind

$17,419,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Physiology
Medicine
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Gergely Lukacs

Physiology

1 shared papers, latest 2016

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2019

Subject: Prospective PhD student: Long Qt Syndrome Dear Professor Shrier, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Phase resetting in human stem cell derived cardiomyocytes explains complex cardiac arrhythmias." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Quality control and pharmacological rescue of heteromeric long QT mutants" (2019), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Alvin Shrier

Research

Latest papers

Latest funding

Phase resetting in human stem cell derived cardiomyocytes explains complex cardiac arrhythmias.

Dependence of premature ventricular complexes on heart rate-it's not that simple.

Predicting discrete-time bifurcations with deep learning.

Rhythms from Two Competing Periodic Sources Embedded in an Excitable Medium.

KHz-rate volumetric voltage imaging of the whole Zebrafish heart.

Universal mechanisms for self-termination of rapid cardiac rhythm.

High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants.

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block.

Hsp70 and DNAJA2 limit CFTR levels through degradation.

Double-wave reentry in excitable media.

Characterization of hERG mutant cardiomyocytes derived from human pluripotent stem cells

Quality control and pharmacological rescue of heteromeric long QT mutants

Molecular Mechanisms of hERG Quality Control

Molecular mechanisms of Long-QT Syndrome Type-2 caused by cell surface destabilization of hERG

Mathematics of Information Technology and Complex Systems/Les mathématiques des technologies de l'information et des systèmes complexes

CIHR Training Program in Integrative Approaches to Human Health

Micromachining facility access

Mathematics of Information Technology and Complex Systems (MITACS)

Frequent collaborators

Gil Bub

John Orlowski

Zachary Laksman

Vidal Essebag

Stanley Nattel

Gergely Lukacs

Alvin Shrier

Research

Latest papers

Latest funding

Phase resetting in human stem cell derived cardiomyocytes explains complex cardiac arrhythmias.

Dependence of premature ventricular complexes on heart rate-it's not that simple.

Predicting discrete-time bifurcations with deep learning.

Rhythms from Two Competing Periodic Sources Embedded in an Excitable Medium.

KHz-rate volumetric voltage imaging of the whole Zebrafish heart.

Universal mechanisms for self-termination of rapid cardiac rhythm.

High-throughput phenotyping of heteromeric human ether-&#xe0;-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants.

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block.

Hsp70 and DNAJA2 limit CFTR levels through degradation.

Double-wave reentry in excitable media.

Characterization of hERG mutant cardiomyocytes derived from human pluripotent stem cells

Quality control and pharmacological rescue of heteromeric long QT mutants

Molecular Mechanisms of hERG Quality Control

Molecular mechanisms of Long-QT Syndrome Type-2 caused by cell surface destabilization of hERG

Mathematics of Information Technology and Complex Systems/Les mathématiques des technologies de l'information et des systèmes complexes

CIHR Training Program in Integrative Approaches to Human Health

Micromachining facility access

Mathematics of Information Technology and Complex Systems (MITACS)

Frequent collaborators

Gil Bub

John Orlowski

Zachary Laksman

Vidal Essebag

Stanley Nattel

Gergely Lukacs

High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants.