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Research
Latest papers
Inhibitors of RNA editing as potential chemotherapeutics against trypanosomatid pathogens.
International journal for parasitology. Drugs and drug resistance · 2012 · senior author
Functional genome annotation by combined analysis across microarray studies of Trypanosoma brucei.
PLoS neglected tropical diseases · 2010 · first author
Latest funding
- $1,136,025
Targeting drug tolerant persister cells in poor outcome breast cancer
CIHR · 2024 · Co-investigator
- $956,250
Targeting Age-Activated Proinflammatory Chemokine Signaling by CCL2/11 to Enhance Skeletal Muscle Regeneration in Aging
CIHR · 2023 · Co-investigator
- $90,000
Générer des contrefactuels pour la biologie moléculaire: une nouvelle approche basée sur des modèles d'apprentissage profond génératifs
NSERC · 2023 · Co-investigator
2 publications.
Inhibitors of RNA editing as potential chemotherapeutics against trypanosomatid pathogens.
Salavati R, Moshiri H, Kala S, Shateri Najafabadi H
Functional genome annotation by combined analysis across microarray studies of Trypanosoma brucei.
Shateri Najafabadi H, Salavati R
Targeting drug tolerant persister cells in poor outcome breast cancer
Principal investigators: Park, Morag
Keywords: Bioinformatics; Chemotherapy-Induced Senescence; Drug Tolerant Persistor Cells; Epigenetics; Patient Derived Xenografts; Patient Minimal Residual Disease; Residual Disease; Spatial Transcriptomics; Triple Negative Breast Cancer
Targeting Age-Activated Proinflammatory Chemokine Signaling by CCL2/11 to Enhance Skeletal Muscle Regeneration in Aging
Principal investigators: Soleimani, Vahab D
Keywords: Aging; Cell Biology; Muscle Atrophy; Muscle Stem Cell Biology; Regenerative Medicine; Rejuvenation; Single Cell Technologies; Stem Cell Niche
Générer des contrefactuels pour la biologie moléculaire: une nouvelle approche basée sur des modèles d'apprentissage profond génératifs
Principal investigators: Emad, Amin A
Keywords: Counterfactual synthesis; Deep Learning; Generative neural networks; mRNA stability; Perturbation prediction; Single cell transcriptomics
Canada Research Chair - Tier 2
Principal investigators: Shateri Najafabadi, Hamed
Keywords: Crc
Identification of biomarkers using single cell technology that inform on optimal duration of immunotherapy treatment in melanoma
Principal investigators: Watson, Ian R; Baetz, Tara; Dancey, Janet E; Song, Xinni
Keywords: Image Mass Cytometry; Immune Checkpoint Inhibitors; Immunotherapy; Melanoma Tumor Microenvironment; Single Cell Epigenetic Profiling; Single Cell Sequencing; Single Cell Technology
Single-cell probing of epigenetic memory in immunity
Principal investigators: Langlais, David
Keywords: 3d Genome; Autoimmunity; Chromosome Conformation Capture; Chronic Inflammation; Epigenetic Reprogramming; Epigenomics; Trained Immunity; Transcription Factor
Characterization of oncogenic splicing pathways driven by RNA-binding proteins
Principal investigators: Shateri Najafabadi, Hamed
Keywords: Bioinformatics; Cancer Genomics; Computational Biology; Functional Genomics; Gene Regulation; Rna Splicing; Rna-Binding Proteins; Systems Biology; Transcriptomics
Understanding the driving forces behind cellular heterogeneity in cancer
Principal investigators: Shateri Najafabadi, Hamed
Keywords: Intra-tumour heterogeneity; Gene regulation; Singe-cell RNA-seq; Epigenetics; Systems biology; Statistical modeling; Machine learning
Mechanisms of DNA binding and gene regulation by C2H2 zinc finger proteins
Principal investigators: ShateriNajafabadi, Hamed
Modelling the regulatory networks that govern mRNA stability and their implication in cancer
Principal investigators: Perron, Gabrielle
Keywords: Bioinformatics; Cancer; Computational Biology; Functional Genomics; Gene Regulation; Micro-Rnas; Mrna Stability; Post-Transcriptional Gene Regulation; Rna-Binding Proteins; Transcriptomics
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
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