Jean-Francois Poulin

Research

Alpha Synuclein Cell Death Dopamine Parkinson'S Disease Retinoic Acid

Latest papers

Synergistic deficits in parvalbumin interneurons and dopamine signaling drive ACC dysfunction in chronic pain.
Proceedings of the National Academy of Sciences of the United States of America · 2025
Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson's disease.
eLife · 2025
Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson's disease.
bioRxiv : the preprint server for biology · 2024

All 6 publications

Latest funding

Preventing Synucleinopathy in a Marmoset Model of Parkinson's Disease
CIHR · 2026 · Co-investigator
$1,143,676
Unveiling the Role of Synaptic Transmission and Glycolysis on the Selective Vulnerability of Dopaminergic Neuronal Subtypes to Parkinson's disease
CIHR · 2023 · Supervisor
$105,000
Retinoic acid determines the selective vulnerability of dopamine neurons in Parkinson's disease
CIHR · 2022 · Nominated PI
$918,000

All 6 grants and awards

6 publications.

01

Synergistic deficits in parvalbumin interneurons and dopamine signaling drive ACC dysfunction in chronic pain.

Lançon K, Tian J, Bach H, Drapeau P, Poulin JF, Séguéla P

Proceedings of the National Academy of Sciences of the United States of America2025

DOI: 10.1073/pnas.2502558122 PMID: 40569386

02

Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson's disease.

Gaertner Z, Oram C, Schneeweis A, Schonfeld E, Bolduc C, Chen C, Dombeck D, Parisiadou L, Poulin JF, Awatramani R

eLife2025

DOI: 10.7554/elife.101035 PMID: 40353820

03

Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson's disease.

Gaertner Z, Oram C, Schneeweis A, Schonfeld E, Bolduc C, Chen C, Dombeck D, Parisiadou L, Poulin JF, Awatramani R

bioRxiv : the preprint server for biology2024

DOI: 10.1101/2024.06.06.597807 PMID: 38895448

04

Editorial: Dopamine Neuron Diversity in Circuits and Diseases.

Poulin JF, Lerner TN, Howe MW

Frontiers in neural circuits2022First author

DOI: 10.3389/fncir.2022.856716 PMID: 35310549

05

Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins.

Pereira Luppi M, Azcorra M, Caronia-Brown G, Poulin JF, Gaertner Z, Gatica S, Moreno-Ramos OA, Nouri N, Dubois M, Ma YC, Ramakrishnan C, Fenno L, Kim YS, Deisseroth K, Cicchetti F, Dombeck DA, Awatramani R

Cell reports2021

DOI: 10.1016/j.celrep.2021.109975 PMID: 34758317

06

Classification of Midbrain Dopamine Neurons Using Single-Cell Gene Expression Profiling Approaches.

Poulin JF, Gaertner Z, Moreno-Ramos OA, Awatramani R

Trends in neurosciences2020First author

DOI: 10.1016/j.tins.2020.01.004 PMID: 32101709

Preventing Synucleinopathy in a Marmoset Model of Parkinson's Disease

Co-investigatorCIHR2026Project Grant

Principal investigators: Huot, Philippe

Keywords: Alpha-Synuclein; Crispr; Dopaminergic Neurons; Marmoset; Parkinson'S Disease; Positron Emission Tomography; Selective Neuronal Vulnerability; Single-Nucleus Rna-Sequencing; Spatial Transcriptomics; Substantia Nigra Compacta

$1,143,676

Unveiling the Role of Synaptic Transmission and Glycolysis on the Selective Vulnerability of Dopaminergic Neuronal Subtypes to Parkinson's disease

SupervisorCIHR2023Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Bolduc, Cyril

Keywords: Alpha-Synuclein; Bioenergetic; Calb1; Dopamine; Glycolysis; Lewy Body; Neurotransmission; Oxphos; Parkinson'S Disease; Selective Vulnerability

$105,000

Retinoic acid determines the selective vulnerability of dopamine neurons in Parkinson's disease

Nominated PICIHR2022Project Grant

Principal investigators: Poulin, Jean-Francois

Keywords: Alpha Synuclein; Cell Death; Dopamine; Parkinson'S Disease; Retinoic Acid

$918,000

TIRANT: A novel transsynaptic labeling approach to map neuronal circuits

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Poulin, Jean-Francois

$148,000

TIRANT: A novel transsynaptic labeling approach to map neuronal circuits

Principal investigatorNSERC2021Discovery Launch Supplement

Principal investigators: Poulin, Jean-Francois

$12,500

How retinoic acid makes dopaminergic neuron subtypes more vulnerable in Parkinson's Disease

SupervisorCIHR2021Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Sung, Chin Chia

Keywords: A-Synuclein; Aldh1a1; Parkinson'S Disease; Retinoic Acid; Selective Vulnerability

$105,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Neurology and Neurosurgery
Neurosciences
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Pierre Drapeau

Neurosciences

1 shared papers, latest 2025

Francesca Cicchetti

Faculty

1 shared papers, latest 2021

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Alpha Synuclein Dear Professor Poulin, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Synergistic deficits in parvalbumin interneurons and dopamine signaling drive ACC dysfunction in chronic pain." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Retinoic acid determines the selective vulnerability of dopamine neurons in Parkinson's disease" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]