Faculty profile
Jean-François Trempe
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Research
Latest papers
N-terminal acetylation reduces synuclein pathology in models of Parkinson's disease.
Neurobiology of disease · 2026
Digenic inheritance of mutations in SPG7 and AFG3L2 causes motor neuron and cerebellar disorders.
BMC medicine · 2026
Selective inhibitors of the TrkC.T1 receptor reduce retinal inflammation and delay neuronal death in a model of retinitis pigmentosa.
PNAS nexus · 2025
Latest funding
- $589,050
The Sex Hormone Crossroad of Carotid Plaque Instability
CIHR · 2026 · Co-investigator
- $120,000
Uncovering the role of PINK1 mRNA in Parkinson's Disease and Mitochondrial Quality Control
CIHR · 2025 · Supervisor
- $902,700
Inositol Phosphates Analogs to Disarm the Intestinal Pathogen Clostridioides difficile
CIHR · 2025 · Co-investigator
5 publications.
N-terminal acetylation reduces synuclein pathology in models of Parkinson's disease.
Del Cid-Pellitero E, Goiran T, Al-Azzawi ZAM, Karpilovsky NC, Jones-Tabah J, Mayo JJ, Larroquette F, Luo W, Shlaifer I, Thattikota Y, Bayne A, Trempe JF, Durcan TM, Fon EA
Digenic inheritance of mutations in SPG7 and AFG3L2 causes motor neuron and cerebellar disorders.
Estiar MA, Yu E, Varghaei P, Ross JP, Ashtiani S, Bayne AN, Coarelli G, Timmann D, Klockgether T, Beijer D, Mengel D, Coutelier M, Project MinE ALS Sequencing Consortium, Dion PA, Suchowersky O, Ewenczyk C, Goizet C, Stevanin G, Van Damme P, Al-Chalabi A, Zuchner S, Synofzik M, Veldink JH, Trempe JF, Durr A, Rouleau GA, Gan-Or Z
Selective inhibitors of the TrkC.T1 receptor reduce retinal inflammation and delay neuronal death in a model of retinitis pigmentosa.
Brahimi F, Nassour H, Galan A, Guruswamy R, Ortiz C, Nejatie A, Nedev H, Trempe JF, Saragovi HU
Evidence for Non‐Mendelian Inheritance in Spastic Paraplegia 7
Estiar MA, Yu E, Salem IH, Ross JP, Mufti K, Akçimen F, Leveille E, Spiegelman D, Ruskey JA, Asayesh F
SMPD1 mutations, activity, and α-synuclein accumulation in Parkinson's disease.
Alcalay RN, Mallett V, Vanderperre B, Tavassoly O, Dauvilliers Y, Wu RYJ, Ruskey JA, Leblond CS, Ambalavanan A, Laurent SB, Spiegelman D, Dionne-Laporte A, Liong C, Levy OA, Fahn S, Waters C, Kuo SH, Chung WK, Ford B, Marder KS, Kang UJ, Hassin-Baer S, Greenbaum L, Trempe JF, Wolf P, Oliva P, Zhang XK, Clark LN, Langlois M, Dion PA, Fon EA, Dupre N, Rouleau GA, Gan-Or Z
The Sex Hormone Crossroad of Carotid Plaque Instability
Principal investigators: Daskalopoulou, Stella S
Keywords: Atherosclerosis; Lcms; Maldi; Sex Differences; Sex Hormones; Spatial Proteomics; Spatial Transcriptomics
Uncovering the role of PINK1 mRNA in Parkinson's Disease and Mitochondrial Quality Control
Principal investigators: Lazzari, Luca
Keywords: Microscopy; Mitochondria; Mrna; Parkinson'S Disease; Pink1; Proteomics; Single-Molecule Imaging; Stress-Response; Translation
Inositol Phosphates Analogs to Disarm the Intestinal Pathogen Clostridioides difficile
Principal investigators: Castagner, Bastien
Keywords: Anti-Virulence Approach; Antibacterial; Bacterial Toxin; C. Difficile Infection; Clostridioides Difficile; Drug Design; Inositol Phosphate; Structural Biology
The role of the TOM and TIM complexes in stabilizing PINK1 on damaged mitochondria
Principal investigators: Romanelli, Sabrina
Keywords: Damage Sensing; Mitochondria; Parkin; Parkinson'S Disease; Pink1; Pink1-Tom-Tim Complex; Tim-Complex; Tim50; Tom-Complex; Tom7
Role of Mitochondrial Import and Processing of PINK1 in Parkinson Disease
Principal investigators: Fon, Edward A
Keywords: Ipscs; Mitochondria; Mitophagy; Neurodegeneration; Parkin; Parkinson Disease; Pink1; Ubiquitin
early Prediction of preeclampsia using Urinary biomarkers anaLyseS in high-risk prEgnancies (PULSE-U)
Principal investigators: Daskalopoulou, Stella S
Keywords: High-Risk Pregnancies; Machine Learning; Multicentre; Multinational; Prediction; Preeclampsia; Urinary Biomakers; Validation
Advancing POP inhibitors as potential Parkinson's disease therapeutics
Principal investigators: Moitessier, Nicolas R
Keywords: Alpha-Synuclein Aggregation; Disease Modifying Therapy; Parkinson'S Disease; Therapeutics
Vascular redox signaling and Nox5 define the vasculome in hypertension
Principal investigators: Touyz, Rhian M
Keywords: Cell Biology; Hypertension; Redox Biology; Small Vessel Disease; Vascular Biology
Molecular Tools that Block Maturation of the Nuclear Lamin A, Leading to Decrease in Proliferation and Metastasis of Pancreatic Ductal Adenocarcinoma and Colorectal Cancer
Principal investigators: Tsantrizos, Youla S
Keywords: Anti-Tumor Agents For Colorectal Cancer; Anti-Tumor Agents For Pancreatic Ductal Adenocarcinoma; Drug Discovery
Structural studies and development of chemical probes for PINK1, a mitochondrial ubiquitin kinase implicated in Parkinson's disease
Principal investigators: Trempe, Jean-François
Keywords: Cryoelectron Microscopy; Drug Design; Kinase; Mass Spectrometry; Mitochondria; Parkinson'S Disease; Phosphorylation; Pink1; Ubiquitin; X-Ray Crystallography
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Pharmacology and Therapeutics
- Neurology and Neurosurgery
- Pediatrics
Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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