Jean-Philip Lumb, McGill University

Research

Breast Cancer Fluorine-18 Gastrin-Releasing Peptide Receptor (Grpr)Heterocyclic Silicon Fluoride Acceptors (Hetsifa)Lutetium-177 Positron Emission Tomography (Pet)Prostate Cancer Radioligand Therapy (Rlt)

Latest papers

Silapiperidine-silicon-fluoride acceptors (Pip-SiFA) for 18F-radiolabelling.
Chemical communications (Cambridge, England) · 2026 · senior author
Development of Heteroaromatic Silicon Fluoride Acceptors (HetSiFAs) for 18F‑Labeled Radiopharmaceuticals
Journal of Medicinal Chemistry · 2025
From melanogenesis to melanin technologies.
Communications chemistry · 2025

All 29 publications

Latest funding

Temperature Controlled Resonant Acoustic Mixer to Amplify Mechanochemistry Synthesis and Polymer Functionalization
NSERC · 2025 · Co-investigator
$150,000
A Sustainable Approach to Base Metal Extraction from Minerals Using Resonant Acoustic Mixing and Electrolytic Extraction
NSERC · 2024 · Principal investigator
$142,558
Bioinspired Synthesis and Catalysis
NSERC · 2024 · Principal investigator
$69,000

All 14 grants and awards

29 publications.

01

Silapiperidine-silicon-fluoride acceptors (Pip-SiFA) for 18F-radiolabelling.

Burley D, Singleton TA, Edelmann S, Kostikov A, Lumb JP

Chemical communications (Cambridge, England)2026Senior author

DOI: 10.1039/d6cc02632j PMID: 42383449

02

Development of Heteroaromatic Silicon Fluoride Acceptors (HetSiFAs) for 18F‑Labeled Radiopharmaceuticals

Singleton TA, Jun H, Deore PS, Estrada C, Atienza BJP, Delecueillerie J, El-Zaria ME, Genady AR, Zhao E, Edelmann S

Journal of Medicinal Chemistry20253 citations

DOI: 10.1021/acs.jmedchem.5c01087

03

From melanogenesis to melanin technologies.

Al-Shamery N, Biyashev D, Blancafort L, Camus A, Gianneschi NC, De Olivera Graeff CF, Kohler B, Li S, Lu KQ, Lumb JP, Manini P, McNamara M, Meredith P, Mostert AB, Nelson TL, Ozlu B, Rossi V, Shanta F, Shawkey M, Shim BS, Surman AJ, Xie W, Santato C, Matta M

Communications chemistry2025

DOI: 10.1038/s42004-025-01731-8 PMID: 41188615

04

An iterative synthesis of poly-substituted indole oligomers reveals a short effective conjugation length in eumelanin model compounds.

Huang H, Kinziabulatova L, Manickoth A, Zhang Y, Barilla MA, Blancafort L, Kohler B, Lumb JP

Chemical science2025Senior author

DOI: 10.1039/d4sc08610d PMID: 39981036

05

A para- to meta-isomerization of phenols.

Edelmann S, Lumb JP

Nature chemistry2024Senior author

DOI: 10.1038/s41557-024-01512-1 PMID: 38632366

06

Mechanisms for radical reactions initiating from N-hydroxyphthalimide esters.

Azpilcueta-Nicolas CR, Lumb JP

Beilstein journal of organic chemistry2024Senior author

DOI: 10.3762/bjoc.20.35 PMID: 38410775

07

A Bioinspired Synthesis of 1,4-Benzothiazines by Selective Addition of Sulfur Nucleophiles to ortho-Quinones.

Halloran MW, Li E, Esguerra KVN, Lumb JP

The Journal of organic chemistry2023Senior author

DOI: 10.1021/acs.joc.2c02463 PMID: 36719706

08

Indole-5,6-quinones display hallmark properties of eumelanin.

Wang X, Kinziabulatova L, Bortoli M, Manickoth A, Barilla MA, Huang H, Blancafort L, Kohler B, Lumb JP

Nature chemistry2023Senior author

DOI: 10.1038/s41557-023-01175-4 PMID: 37037912

09

Dearomatization of Biaryls through Polarity Mismatched Radical Spirocyclization.

Azpilcueta-Nicolas CR, Meng D, Edelmann S, Lumb JP

Angewandte Chemie (International ed. in English)2023Senior author

DOI: 10.1002/anie.202215422 PMID: 36454656

10

Mimicking oxidative radical cyclizations of lignan biosynthesis using redox-neutral photocatalysis.

Huang Z, Lumb JP

Nature chemistry2021Senior author

DOI: 10.1038/s41557-020-00603-z PMID: 33349693

Temperature Controlled Resonant Acoustic Mixer to Amplify Mechanochemistry Synthesis and Polymer Functionalization

Co-investigatorNSERC2025Research Tools and Instruments

Principal investigators: Moores, Audrey

Keywords: resonant acoustic mixing; mechanochemistry; biomass valorization; polymer functionalization

$150,000

A Sustainable Approach to Base Metal Extraction from Minerals Using Resonant Acoustic Mixing and Electrolytic Extraction

Principal investigatorNSERC2024Alliance Grants

Principal investigators: Lumb, Jean-Philip J-PG

Keywords: coordination chemistry; electrochemistry; electrowinning; hydrometallurgy; inorganic chemistry; mechanochemistry; metal extraction; metal separation; oxidation chemistry; oxidative dissolution

$142,558

Bioinspired Synthesis and Catalysis

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Lumb, Jean-Philip

Keywords: organic synthesis; oxidation; phenols/catechols; dearomatization; copper; aerobic oxidation; natural products; radical reactions; melanin

$69,000

Using Mechanochemistry and Electrowinning to Improve Gold Production

Co-investigatorNSERC2024Alliance Grants

Principal investigators: Mauzeroll, Janine J

Keywords: electrowinning; gold; mechanochemistry; refining

$127,260

Development of radiotwin 18F/177Lu theranostic radiopharmaceuticals targeting gastrin-releasing peptide receptor (GRPR)

Principal investigatorCIHR2023Project Grant

Principal investigators: Kostikov, Alexey; Lumb, Jean-Philip G; Sadeghi, Saman

Keywords: Breast Cancer; Fluorine-18; Gastrin-Releasing Peptide Receptor (Grpr); Heterocyclic Silicon Fluoride Acceptors (Hetsifa); Lutetium-177; Positron Emission Tomography (Pet); Prostate Cancer; Radioligand Therapy (Rlt); Theranostic Radiopharmaceuticals

$956,250

Commercialization of Treeyon : A Wood-Based, Bio-Degradable Alternative to Synthetic Fibers

Co-investigatorNSERC2022Idea to Innovation

Principal investigators: van de Ven, Theodorus TGM

$125,000

Using dynamic flow electrolysis and mechanochemistry to enhance the performance of gold production.

Co-investigatorNSERC2021Alliance Grants

Principal investigators: Mauzeroll, Janine

$459,714

INTERCEPTORs: engINeered ThERapeutiC dEfensive Particles TO SARS-CoV-2

Co-investigatorCIHR2020Operating Grant: COVID-19 Rapid Research Funding Opportunity - Therapeutics

Principal investigators: Sonenberg, Nahum; Pelletier, Jerry M

Keywords: Biotherapeutic; Coronavirus; Covid-19; Defective Interfering Particles; Recombination; Reverse Genetics; Sars-Cov-2; Severe Acute Respiratory Syndrome

$745,124

Photon III X-ray detector for metal jet diffractometer

Co-investigatorNSERC2019Research Tools and Instruments

Principal investigators: Schaper, Frank

$149,711

Market assessment of ""A technology platform for novel cured cellulose filaments for textile production""

Co-investigatorNSERC2019Idea to Innovation

Principal investigators: vandeVen, Theodorus

$11,250

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Neurology and Neurosurgery
Chemistry & Chemical Biology

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Alexey Kostikov

Neurology and Neurosurgery

2 shared papers, latest 2026

Saman Sadeghi

Chemistry & Chemical Biology

1 shared papers, latest 2025

Write to this professor

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Applying for

Paper to mentionMention their NSERC grant from 2024

Subject: Prospective PhD student: Breast Cancer Dear Professor Lumb, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Silapiperidine-silicon-fluoride acceptors (Pip-SiFA) for 18F-radiolabelling." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "A Sustainable Approach to Base Metal Extraction from Minerals Using Resonant Acoustic Mixing and Electrolytic Extraction" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]