Laura Stone, McGill University

Research

Animal Models Discogenic Pain Intervertebral Disc Degeneration Low Back Pain Bone Fracture Healing Bone Healing Chronotherapy Nsaid

Latest papers

The methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex.
Pain reports · 2021 · senior author
Opioid-receptor antagonism increases pain and decreases pleasure in obese and non-obese individuals.
Psychopharmacology · 2016
Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations.
Pain · 2016

All 3 publications

Latest funding

Epigenetic age acceleration and overall mortality among cancer survivors
CIHR · 2024 · Co-investigator
$70,000
Development and performance of a model combining a polygenic risk score and biopsychosocial measures to predict the transition of acute to chronic low back pain
CIHR · 2023 · Co-investigator
$596,700
Regenerative approaches to treat back-pain in mice and men
CIHR · 2021 · Co-investigator
$826,200

All 13 grants and awards

3 publications.

01

The methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex.

Topham L, Gregoire S, Kang H, Salmon-Divon M, Lax E, Millecamps M, Szyf M, Stone L

Pain reports2021Senior author

DOI: 10.1097/pr9.0000000000000944 PMID: 34278163

02

Opioid-receptor antagonism increases pain and decreases pleasure in obese and non-obese individuals.

Price RC, Christou NV, Backman SB, Stone L, Schweinhardt P

Psychopharmacology2016

DOI: 10.1007/s00213-016-4417-4 PMID: 27659699

03

Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations.

Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice ASC, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I, McDermott MP, McMahon SB, Price TJ, Ross SE, Scherrer G, Seal RP, Sena ES, Silva E, Stone L, Svensson CI, Turk DC, Whiteside G

Pain2016

DOI: 10.1097/j.pain.0000000000000458 PMID: 26683237

Epigenetic age acceleration and overall mortality among cancer survivors

Co-investigatorCIHR2024Catalyst Grant: Analysis of CLSA Data - IA Early Career Researchers

Principal investigators: Madathil, Sreenath A; Nicolau, Belinda F

Keywords: Artificial Intelligence; Chronic Diseases; Epigenetic Age Acceleartion; Mortality

$70,000

Development and performance of a model combining a polygenic risk score and biopsychosocial measures to predict the transition of acute to chronic low back pain

Co-investigatorCIHR2023Project Grant

Principal investigators: Beraldo Meloto, Carolina; Grant, Audrey V

Keywords: Acute-To-Chronic Transition; Biopsychosocial Factors; Genetic Variants; Large Scale Cohorts; Low Back Pain; Polygenic Risk Score

$596,700

Regenerative approaches to treat back-pain in mice and men

Co-investigatorCIHR2021Project Grant

Principal investigators: Haglund, Lisbet A

Keywords: Back Pain; Cell Senescence; Osteoarthritis

$826,200

Chronotherapy of Non-Steroidal Anti Inflammatory Drugs could enhance bone fracture recovery

Principal investigatorCIHR2019Project Grant

Principal investigators: Tamimi, Faleh; Stone, Laura S

Keywords: Bone Fracture Healing; Bone Healing; Chronotherapy; Nsaid; Postoperative Pain

$558,450

DNA Methylation and Mediation of Risk Factors for Chronic Facial Pain

Co-investigatorCIHR2018Operating Grant: Epigenetics Clinical Translation

Principal investigators: Diatchenko, Luda

Keywords: Human Genetics; Human Pain Conditions; Methylation Markerts

$1,498,617

Central nervous system mechanisms underlying the effects of exercise therapy on chronic low back pain .

Co-investigatorCIHR2017Project Grant

Principal investigators: Roy, Mathieu

Keywords: Brain Imaging; Chronic Low Back Pain; Inflammation; Physical Exercise

$642,600

Molecular mechanisms of intervertebral disc degeneration and pain

Co-investigatorCIHR2016Project Grant

Principal investigators: Haglund, Lisbet A

Keywords: Ivd Degeneration And Pain; Sterile Inflammation; Toll Like Receptors

$573,375

Epigenetic Mechanisms in Chronic Pain

Nominated PICIHR2016Project Grant

Principal investigators: Stone, Laura S

Keywords: Animal Models; Central Nervous System; Chronic Pain; Epigenetics; Nerve Injury

$898,290

Low back pain: from mechanism to therapeutic intervention

Nominated PICIHR2015Operating Grant

Principal investigators: Stone, Laura S

Keywords: Animal Models; Discogenic Pain; Intervertebral Disc Degeneration; Low Back Pain; Sparc; Therapeutics; Translational

$777,751

The Intervertebral Disc as A Source of Low Back Pain In Humans and in Animal Models

Nominated PICIHR2012Operating Grant

Principal investigators: Stone, Laura S

Keywords: Animal Models; Discogenic Pain; Intervertebral Disc Degeneration; Low Back Pain

$662,720

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Pharmacology and Therapeutics
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Petra Schweinhardt

Faculty

1 shared papers, latest 2016

Moshe Szyf

Pharmacology and Therapeutics

1 shared papers, latest 2021

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2019

Subject: Prospective PhD student: Animal Models Dear Professor Stone, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex." (2021), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Chronotherapy of Non-Steroidal Anti Inflammatory Drugs could enhance bone fracture recovery" (2019), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]