Loydie Jerome-Majewska, McGill University

Research

Congenital Malformations Splicing Ccms Mouse Model Snrpb Craniofacial Development Mfdm Mouse Models

Latest papers

Pluripotency of a founding field: rebranding developmental biology.
Development (Cambridge, England) · 2024
Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.
EMBO molecular medicine · 2019
High intake of folic acid disrupts embryonic development in mice.
Birth defects research. Part A, Clinical and molecular teratology · 2011

All 4 publications

Latest funding

Mouse Models of Spliceosomopathies: The Role of Snrpb in Axial Development
CIHR · 2024 · Nominated PI
$963,900
Etiology of SF3B4-related disorders in posterior nerual crest disease
CIHR · 2024 · Supervisor
$210,000
The role of spliceosome proteins in disease and development
CIHR · 2022 · Nominated PI
$749,700

All 10 grants and awards

4 publications.

01

Pluripotency of a founding field: rebranding developmental biology.

Rogers CD, Amemiya C, Arur S, Babonis L, Barresi M, Bartlett M, Behringer R, Benham-Pyle B, Bergmann D, Blackman B, Brown CT, Browne B, Camacho J, Chabu CY, Chow I, Cleaver O, Cool J, Dennis MY, Dickinson AJ, Di Talia S, Frank M, Gillmor S, Haag ES, Hariharan I, Harland R, Husbands A, Jerome-Majewska L, Koenig K, Labonne C, Layden M, Lowe C, Mani M, Martik M, McKown K, Moens C, Mosimann C, Onyenedum J, Reed R, Rivera A, Rokhsar D, Royer L, Rutaganira F, Shahan R, Sinha N, Swalla B, Van Norman JM, Wagner DE, Wikramanayake A, Zebell S, Brady SM

Development (Cambridge, England)2024

DOI: 10.1242/dev.202342 PMID: 38345109

02

Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.

Maurel M, Obacz J, Avril T, Ding YP, Papadodima O, Treton X, Daniel F, Pilalis E, Hörberg J, Hou W, Beauchamp MC, Tourneur-Marsille J, Cazals-Hatem D, Sommerova L, Samali A, Tavernier J, Hrstka R, Dupont A, Fessart D, Delom F, Fernandez-Zapico ME, Jansen G, Eriksson LA, Thomas DY, Jerome-Majewska L, Hupp T, Chatziioannou A, Chevet E, Ogier-Denis E

EMBO molecular medicine2019

DOI: 10.15252/emmm.201810120 PMID: 31040128

03

High intake of folic acid disrupts embryonic development in mice.

Pickell L, Brown K, Li D, Wang XL, Deng L, Wu Q, Selhub J, Luo L, Jerome-Majewska L, Rozen R

Birth defects research. Part A, Clinical and molecular teratology2011

DOI: 10.1002/bdra.20754 PMID: 21254354

04

Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice.

Pickell L, Li D, Brown K, Mikael LG, Wang XL, Wu Q, Luo L, Jerome-Majewska L, Rozen R

Birth defects research. Part A, Clinical and molecular teratology2009

DOI: 10.1002/bdra.20575 PMID: 19215022

Mouse Models of Spliceosomopathies: The Role of Snrpb in Axial Development

Nominated PICIHR2024Project Grant

Principal investigators: Jerome-Majewska, Loydie A

Keywords: Ccms; Congenital Malformations; Mouse Model; Snrpb; Splicing

$963,900

Etiology of SF3B4-related disorders in posterior nerual crest disease

SupervisorCIHR2024CIHR Fellowship

Principal investigators: Moore, Joshua A

Keywords: Cardiac Development; Craniofacial Development; Development; Enteric Nervous System; Sf3b4; Splicing

$210,000

The role of spliceosome proteins in disease and development

Nominated PICIHR2022Project Grant

Principal investigators: Jerome-Majewska, Loydie A

Keywords: Congenital Malformations; Craniofacial Development; Mfdm; Mouse Models; Nager; Splicing

$749,700

Molecular mechanism of placental Development: The role of TMED2, a vesicular transport protein during labyrinth layer formation

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Jerome-Majewska, Loydie

$192,000

Splicing Defects in Human Hereditary Disease

Co-investigatorCIHR2015Operating Grant

Principal investigators: Majewski, Jacek A

Keywords: Animal Models; Genetic Disease; Genome Editing; Genomics; Rna Sequencing

$528,504

Molecular mechanism of placental development: The role of TMED2, a vesicular transport protein during syncytiotrophoblast formation

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: JeromeMajewska, Loydie

$150,000

Molecular mechanism of Early Pregnancy loss: The role of TMED2

Nominated PICIHR2009Operating Grant

Principal investigators: Jerome-Majewska, Loydie A

Keywords: Chorion; Early Pregnancy Loss; Iugr; Placenta; Protein Trafficking; Tmed Complex

$308,931

Inborn errors of cobalamin and folate metabolism

Co-investigatorCIHR2009Operating Grant

Principal investigators: Rosenblatt, David S

Keywords: Cobalamin; Folate; Homocysteine; Inborn Errors Of Metabolism; Methylmalonic Acid

$979,000

Vitamin B12 in Health and Disease

Co-investigatorCIHR2008Emerging Team Grant: From Genes to Proteins, Cells, Tissues and Patients - LOI

Principal investigators: Rosenblatt, David S

Keywords: Animal Models; Inborn Errors Of Metabolism; Protein Structure And Function; Small Molecule Screening; Vitamin B12

Protein trafficking during placental development: the role of TMED2

Principal investigatorNSERC2008Discovery Grants Program - Individual

Principal investigators: JeromeMajewska, Loydie

$160,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Rima Rozen

Pediatrics/Human Genetics

2 shared papers, latest 2011

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Congenital Malformations Dear Professor Jerome-Majewska, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Pluripotency of a founding field: rebranding developmental biology." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Mouse Models of Spliceosomopathies: The Role of Snrpb in Axial Development" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]