Faculty profile

Rima Rozen

ResearcherPediatrics/Human GeneticsMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Rima Rozen

Researcher

Pediatrics/Human Genetics

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
7 publications in the last five years, latest in 2025.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (6 CIHR), most recently in 2020.
Supervisor on 1 trainee award (1 CIHR), most recently in 2008.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Mthfr Folic Acid Gene-Nutrient Interactions Genetic Polymorphism Folate Developmental Anomalies Folate Metabolism Methyltetrahydrofolate

Latest papers

Contrasting Effects of Phosphatidylcholine and Betaine Supplementation on Embryonic Development in a Mouse Model of the MTHFD1 R653Q Variant.
The Journal of nutrition · 2025 · senior author
Low Dietary Folate Increases Developmental Delays in the Litters of Mthfr677TT Mice.
Nutrients · 2025 · senior author
Folic Acid and Methyltetrahydrofolate Supplementation in the Mthfr677C>T Mouse Model with Hepatic Steatosis.
Nutrients · 2024 · senior author

All 75 publications

Latest funding

Supplementation of folic acid or methyltetrahydrofolate to reduce developmental anomalies in a new mouse model for the MTHFR 677C>T polymorphism
CIHR · 2020 · Nominated PI
$845,326
Adequate intake of choline in pregnancy may be critical for MTHFD1 synthetase deficiency, a common genetic variant in folate metabolism
CIHR · 2017 · Nominated PI
$638,775
Assisted Reproductive Technologies and Folic Acid Supplementation: Gene-environment Interactions and Neurodevelopmental and Metabolic Outcomes in Children
CIHR · 2015 · Principal investigator

All 8 grants and awards

75 publications.

Contrasting Effects of Phosphatidylcholine and Betaine Supplementation on Embryonic Development in a Mouse Model of the MTHFD1 R653Q Variant.

Christensen KE, Faquette ML, Gebert AT, Keser V, Bottiglieri T, Rozen R

The Journal of nutrition2025Senior author

DOI: 10.1016/j.tjnut.2025.07.013 PMID: 40714174

Low Dietary Folate Increases Developmental Delays in the Litters of Mthfr677TT Mice.

Christensen KE, Faquette ML, Keser V, Reagan AM, Gebert AT, Bottiglieri T, Howell GR, Rozen R

Nutrients2025Senior author

DOI: 10.3390/nu17152536 PMID: 40806120

Folic Acid and Methyltetrahydrofolate Supplementation in the Mthfr677C>T Mouse Model with Hepatic Steatosis.

Christensen KE, Faquette ML, Leclerc D, Keser V, Luan Y, Bennett-Firmin JL, Malysheva OV, Reagan AM, Howell GR, Caudill MA, Bottiglieri T, Rozen R

Nutrients2024Senior author

DOI: 10.3390/nu17010082 PMID: 39796516

Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation.

Martínez Duncker Rebolledo E, Chan D, Christensen KE, Reagan AM, Howell GR, Rozen R, Trasler J

Molecular human reproduction2024

DOI: 10.1093/molehr/gaae008 PMID: 38366926

Folate Deficiency and/or the Genetic Variant Mthfr677C >T Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner.

Leclerc D, Christensen KE, Reagan AM, Keser V, Luan Y, Malysheva OV, Wasek B, Bottiglieri T, Caudill MA, Howell GR, Rozen R

Molecular nutrition & food research2024Senior author

DOI: 10.1002/mnfr.202300355 PMID: 38327171

The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice.

Reagan AM, Christensen KE, Graham LC, Bedwell AA, Eldridge K, Speedy R, Figueiredo LL, Persohn SC, Bottiglieri T, Nho K, Sasner M, Territo PR, Rozen R, Howell GR

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

DOI: 10.1177/0271678x221122644 PMID: 36050860

Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Sex-Specific Gene Expression in Brain of Young Mice and Embryos.

Luan Y, Cosín-Tomás M, Leclerc D, Malysheva OV, Caudill MA, Rozen R

Nutrients2022Senior author

DOI: 10.3390/nu14051051 PMID: 35268026

Mild Choline Deficiency and MTHFD1 Synthetase Deficiency Interact to Increase Incidence of Developmental Delays and Defects in Mice.

Christensen KE, Malysheva OV, Carlin S, Matias F, MacFarlane AJ, Jacobs RL, Caudill MA, Rozen R

Nutrients2021Senior author

DOI: 10.3390/nu14010127 PMID: 35011003

Shifting landscapes of human MTHFR missense-variant effects.

Weile J, Kishore N, Sun S, Maaieh R, Verby M, Li R, Fotiadou I, Kitaygorodsky J, Wu Y, Holenstein A, Bürer C, Blomgren L, Yang S, Nussbaum R, Rozen R, Watkins D, Gebbia M, Kozich V, Garton M, Froese DS, Roth FP

American journal of human genetics2021

DOI: 10.1016/j.ajhg.2021.05.009 PMID: 34214447

Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Methyl Metabolism and in Sex-Specific Placental Transcription Changes.

Luan Y, Leclerc D, Cosín-Tomás M, Malysheva OV, Wasek B, Bottiglieri T, Caudill MA, Rozen R

Molecular nutrition & food research2021Senior author

DOI: 10.1002/mnfr.202100197 PMID: 34010503

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2020

Subject: Prospective PhD student: Mthfr Dear Professor Rozen, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Contrasting Effects of Phosphatidylcholine and Betaine Supplementation on Embryonic Development in a Mouse Model of the MTHFD1 R653Q Variant." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Supplementation of folic acid or methyltetrahydrofolate to reduce developmental anomalies in a new mouse model for the MTHFR 677C>T polymorphism" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Rima Rozen

Research

Latest papers

Latest funding

Contrasting Effects of Phosphatidylcholine and Betaine Supplementation on Embryonic Development in a Mouse Model of the MTHFD1 R653Q Variant.

Low Dietary Folate Increases Developmental Delays in the Litters of Mthfr677TT Mice.

Folic Acid and Methyltetrahydrofolate Supplementation in the Mthfr677C>T Mouse Model with Hepatic Steatosis.

Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation.

Folate Deficiency and/or the Genetic Variant Mthfr677C >T Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner.

The 677C&#x2009;>&#x2009;T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice.

Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Sex-Specific Gene Expression in Brain of Young Mice and Embryos.

Mild Choline Deficiency and MTHFD1 Synthetase Deficiency Interact to Increase Incidence of Developmental Delays and Defects in Mice.

Shifting landscapes of human MTHFR missense-variant effects.

Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Methyl Metabolism and in Sex-Specific Placental Transcription Changes.

Supplementation of folic acid or methyltetrahydrofolate to reduce developmental anomalies in a new mouse model for the MTHFR 677C>T polymorphism

Adequate intake of choline in pregnancy may be critical for MTHFD1 synthetase deficiency, a common genetic variant in folate metabolism

Assisted Reproductive Technologies and Folic Acid Supplementation: Gene-environment Interactions and Neurodevelopmental and Metabolic Outcomes in Children

Methylenetetrahydrofolate reductase (MTHFR) and multifactorial diseases

Trifunctional folate-metabolizing enzyme MTHFD1: impact on birth defects and cancer

Methylenetetrahydrofolate reductase (MTHFR) and multifactorial diseases

Impact of genetic polymorphism and folate intake on methyl group utilization in brain

Canadian Genetic Diseases Network (CGDN) / Réseau Canadien de maladies génétiques

Frequent collaborators

Jacques Genest

Jacquetta Trasler

Andrea Richter

Loydie Jerome-Majewska

Nada Jabado

Robert Platt

Michael Garton

Paul Khairy

Pierre Chaurand

Marylise Boutros

Jacques Michaud

Peter Metrakos

Paul Goodyer

Philippe Gros

Louise Seguin

Gregor Andelfinger

Pierre Lachapelle

Nicole Beauchemin

The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice.