René St-Arnaud, McGill University

Research

Bone Cell Differentiation Drug Development Metabolic Bone Disease Osteoblasts Preclinical Testing Klinefelter Syndrome Medicinal Chemistry

Latest papers

Vitamin D supplementation improves bone mineralisation independent of dietary phosphate in male X-linked hypophosphatemic (Hyp) mice.
Bone · 2021
Vitamin D-regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification.
JCI insight · 2019
Fibroblast Growth Factor 23 Regulation by Systemic and Local Osteoblast-Synthesized 1,25-Dihydroxyvitamin D.
Journal of the American Society of Nephrology : JASN · 2017

All 5 publications

Latest funding

A precision medicine approach for treatment of low bone mass in Klinefelter Syndrome
CIHR · 2025 · Nominated PI
$990,675
Compounds blocking FIAT activity increase osteogenesis
CIHR · 2020 · Nominated PI
$497,250
Canadian Research Leaders in Musculoskeletal Health: A Self-Assembled National Consortium
CIHR · 2016 · Co-investigator
$9,999

All 6 grants and awards

5 publications.

01

Vitamin D supplementation improves bone mineralisation independent of dietary phosphate in male X-linked hypophosphatemic (Hyp) mice.

Barratt KR, Sawyer RK, Atkins GJ, St-Arnaud R, Anderson PH

Bone2021

DOI: 10.1016/j.bone.2020.115767 PMID: 33232838

02

Vitamin D-regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification.

Nguyen-Yamamoto L, Tanaka KI, St-Arnaud R, Goltzman D

JCI insight2019

DOI: 10.1172/jci.insight.126467 PMID: 31292298

03

Fibroblast Growth Factor 23 Regulation by Systemic and Local Osteoblast-Synthesized 1,25-Dihydroxyvitamin D.

Nguyen-Yamamoto L, Karaplis AC, St-Arnaud R, Goltzman D

Journal of the American Society of Nephrology : JASN2017

DOI: 10.1681/asn.2016010066 PMID: 27535551

04

Characterizing the BMP pathway in a wild type mouse model of distraction osteogenesis.

Haque T, Hamade F, Alam N, Kotsiopriftis M, Lauzier D, St-Arnaud R, Hamdy RC

Bone2008

DOI: 10.1016/j.bone.2008.01.028 PMID: 18372226

05

Generalization of DNA microarray dispersion properties: microarray equivalent of t-distribution.

Novak JP, Kim SY, Xu J, Modlich O, Volsky DJ, Honys D, Slonczewski JL, Bell DA, Blattner FR, Blumwald E, Boerma M, Cosio M, Gatalica Z, Hajduch M, Hidalgo J, McInnes RR, Miller MC, Penkowa M, Rolph MS, Sottosanto J, St-Arnaud R, Szego MJ, Twell D, Wang C

Biology direct2006

DOI: 10.1186/1745-6150-1-27 PMID: 16959036

A precision medicine approach for treatment of low bone mass in Klinefelter Syndrome

Nominated PICIHR2025Project Grant

Principal investigators: St-Arnaud, René

Keywords: Bone; Cell Differentiation; Drug Development; Klinefelter Syndrome; Medicinal Chemistry; Metabolic Bone Disease; Osteoblasts; Preclinical Testing

$990,675

Compounds blocking FIAT activity increase osteogenesis

Nominated PICIHR2020Project Grant

Principal investigators: St-Arnaud, René

Keywords: Biomechanical Testing; Bone; Cell Differentiation; Control Of Gene Expression; Drug Development; Histomorphometry; Metabolic Bone Disease; Mineralization; Osteoblasts; Preclinical Testing

$497,250

Canadian Research Leaders in Musculoskeletal Health: A Self-Assembled National Consortium

Co-investigatorCIHR2016Planning and Dissemination Grant - Institute Community Support

Principal investigators: Holdsworth, David W

Keywords: Cross-Jurisdictional; Interdisciplinary; Musculoskeletal Health

$9,999

The alphaNAC transcriptional coregulator as a downstream effector of PTH action in bone

Nominated PICIHR2011Operating Grant

Principal investigators: St-Arnaud, René

Keywords: Animal Models Of Bone Disease; Bone Anabolic Effect Of Pth; Gene Expression Monitoring; Gene Transcription; Knockin Mouse Mutagenesis; Osteoporosis; Parathyroid Hormone; Signal Transduction

$627,195

The alphaNAC transcriptional coregulator as a downstream effector of PTH action in bone

Nominated PICIHR2010Operating Grant - PA: Musculoskeletal Health, Arthritis, Skin and Oral Health

Principal investigators: St-Arnaud, René

Keywords: Animal Models Of Bone Disease; Bone Anabolic Effect Of Pth; Gene Expression Monitoring; Gene Transcription; Knockin Mouse Mutagenesis; Osteoporosis; Parathyroid Hormone; Signal Transduction

$100,000

Role of the 24,25-dihydroxyvitamin D metabolite in fracture repair

Principal investigatorNSERC2003Collaborative Research and Development Grants

Principal investigators: StArnaud, Rene

$50,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

David Goltzman

Medicine

2 shared papers, latest 2019

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Bone Dear Professor St-Arnaud, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Vitamin D supplementation improves bone mineralisation independent of dietary phosphate in male X-linked hypophosphatemic (Hyp) mice." (2021), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "A precision medicine approach for treatment of low bone mass in Klinefelter Syndrome" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]