Frédéric Lesage, Polytechnique Montréal

Research

Optical Coherence Tomography Atherosclerosis Bioluminescence Oxygen Imaging Viral Imaging Probes Two-Photon Microscopy Alzheimer Intrinsic Optical Imaging

Latest papers

Deep learning-based prediction of diffusion MRI responses from microvascular OCT angiograms.
Physics in medicine and biology · 2026
Improving microvascular brain analysis with adversarial learning for OCT-TPM vascular domain translation.
Scientific reports · 2025
Chitosan siRNA Nanoparticles Produce Significant Non-Toxic Functional Gene Silencing in Kidney Cortices.
Polymers · 2024

All 22 publications

Latest funding

Ultrasound Localization Microscopy of Single-Capillary Reporter Dynamics in Experimental Stroke
CIHR · 2025 · Co-investigator
$830,025
Ultrafast microscopy and network modeling to underpin microvascular driven brain damage.
NSERC · 2023 · Principal investigator
$162,000
Vascular Optical Imaging
NSERC · 2021 · Principal investigator
$600,000

All 44 grants and awards

22 publications.

01

Deep learning-based prediction of diffusion MRI responses from microvascular OCT angiograms.

Rustamov J, Rustamov Z, Lesage F, Zaki N, Damseh R

Physics in medicine and biology2026

DOI: 10.1088/1361-6560/aeaa9f PMID: 42767249

02

Improving microvascular brain analysis with adversarial learning for OCT-TPM vascular domain translation.

Badawi N, Rustamov J, Rustamov Z, Lesage F, Zaki N, Damseh R

Scientific reports2025

DOI: 10.1038/s41598-025-07410-x PMID: 40646058

03

Chitosan siRNA Nanoparticles Produce Significant Non-Toxic Functional Gene Silencing in Kidney Cortices.

Alameh MG, Tavakoli Naeini A, Dwivedi G, Lesage F, Buschmann MD, Lavertu M

Polymers2024

DOI: 10.3390/polym16172547 PMID: 39274180

04

Evaluation of stenoses using AI video models applied to coronary angiography.

Labrecque Langlais É, Corbin D, Tastet O, Hayek A, Doolub G, Mrad S, Tardif JC, Tanguay JF, Marquis-Gravel G, Tison GH, Kadoury S, Le W, Gallo R, Lesage F, Avram R

NPJ digital medicine2024

DOI: 10.1038/s41746-024-01134-4 PMID: 38783037

05

Exploring cognitive and brain oxygenation changes over a 1-year period in physically active individuals with mild cognitive impairment: a longitudinal fNIRS pilot study.

Talamonti D, Gagnon C, Vincent T, Nigam A, Lesage F, Bherer L, Fraser S

BMC geriatrics2022

DOI: 10.1186/s12877-022-03306-x PMID: 35941561

06

Time-gated interferometric detection increases Raman scattering to fluorescence signal ratio in biological samples.

Ksantini N, Veilleux I, de Denus-Baillargeon MM, Orsini P, Dicaire I, Lecourt JB, Gognau A, Hernandez Y, Baylon A, Massabki M, Lesage F, Leblond F

Journal of biophotonics2022

DOI: 10.1002/jbio.202100188 PMID: 34676670

07

A simulation study investigating potential diffusion-based MRI signatures of microstrokes.

Damseh R, Lu Y, Lu X, Zhang C, Marchand PJ, Corbin D, Pouliot P, Cheriet F, Lesage F

Scientific reports2021Senior author

DOI: 10.1038/s41598-021-93503-2 PMID: 34244549

08

Large-Scale Desynchronization During Interictal Epileptic Discharges Recorded With Intracranial EEG.

Bou Assi E, Zerouali Y, Robert M, Lesage F, Pouliot P, Nguyen DK

Frontiers in neurology2020

DOI: 10.3389/fneur.2020.529460 PMID: 33424733

09

Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation.

Li B, Lu X, Moeini M, Sakadžić S, Thorin E, Lesage F

PloS one2019Senior author

DOI: 10.1371/journal.pone.0221547 PMID: 31469849

10

More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction.

Li B, Esipova TV, Sencan I, Kılıç K, Fu B, Desjardins M, Moeini M, Kura S, Yaseen MA, Lesage F, Østergaard L, Devor A, Boas DA, Vinogradov SA, Sakadžić S

eLife2019

DOI: 10.7554/elife.42299 PMID: 31305237

Ultrasound Localization Microscopy of Single-Capillary Reporter Dynamics in Experimental Stroke

Co-investigatorCIHR2025Project Grant

Principal investigators: Provost, Jean

Keywords: Capillary Transit Time; Dynamic Ultrasound Localization Microscopy; Ultrafast Ultrasound Imaging; Ultrasound Imaging; Ultrasound Localization Microscopy

$830,025

Ultrafast microscopy and network modeling to underpin microvascular driven brain damage.

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Lesage, Frederic

Keywords: Brain imaging; Microscopy; Non-linear optical imaging; Phase-contrast; Vascular diseases

$162,000

Vascular Optical Imaging

Principal investigatorNSERC2021Canada Research Chairs

Principal investigators: Lesage, Frederic

$600,000

Improving epilepsy diagnosis through machine learning-based interpretation of routine electroencephalography recordings

SupervisorCIHR2020Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Lemoine, Émile

Keywords: Artificial Intelligence; Data Science; Diagnosis; Electroencephalography; Epilepsy; Machine Learning; Neurophysiology; Predictive Modeling; Seizures

$105,000

Dynamic Ultrasound Localization Pulsatility Imaging

Co-investigatorCIHR2020Project Grant

Principal investigators: Provost, Jean

Keywords: 3d Ultrafast Ultrasound Imaging; Dementia; Dynamic Ultrasound Localization Microscopy; Pulsatility; Ultrafast Ultrasound Imaging; Ultrasound Localization Microscopy

$673,200

Integrated time-domain micro-optode to facilitate long-term clinical NIRS

Principal investigatorNSERC2018Collaborative Health Research Projects

Principal investigators: Lesage, Frederic

$249,000

Improving the identification of retinal biomarkers of Alzheimer disease in vivo

Principal investigatorNSERC2018Collaborative Health Research Projects

Principal investigators: Lesage, Frederic

$260,035

Ultrafast optical coherence tomography algorithms for real-time processing**********

Principal investigatorNSERC2018Engage Grants Program

Principal investigators: Lesage, Frederic

$25,000

Bridging the scales: Modeling macroscopic imaging from microscopy

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Lesage, Frederic

$420,000

Design of a bracelet embedding high-frequency ultrasound transducers to acquire venous blood echogenicity spectral data for patient monitoring

Co-investigatorNSERC2017Collaborative Health Research Projects

Principal investigators: Cloutier, Guy

$301,262

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Jean-Claude Tardif and Jean-Claude Tardif: 380 shared papers
Louis Bherer and Louis Bherer: 171 shared papers
Louis Bherer and Louis Bherer: 171 shared papers
Louis Bherer and Louis Bherer: 171 shared papers
Eric Thorin and Eric Thorin: 81 shared papers
Louis Bherer and Anil Nigam: 50 shared papers
Louis Bherer and Anil Nigam: 49 shared papers
Louis Bherer and Anil Nigam: 49 shared papers
Dominique Trudel and Dominique Trudel: 48 shared papers
Mohamad Sawan and Mohamad Sawan: 45 shared papers
Frederic Leblond and Frederic Leblond: 25 shared papers
Frédéric Lesage and Frédéric Lesage: 22 shared papers
Guillaume Marquis-Gravel and Robert Avram: 14 shared papers
Mohamad Sawan and Elie Bou Assi: 6 shared papers
Mohamad Sawan and Elie Bou Assi: 6 shared papers
Jean-Claude Tardif and Eric Thorin: 5 shared papers
Jean-Claude Tardif and Eric Thorin: 5 shared papers
Jean-Claude Tardif and Eric Thorin: 5 shared papers
Jean-Claude Tardif and Eric Thorin: 5 shared papers
Frederic Leblond and Dominique Trudel: 5 shared papers
Frederic Leblond and Dominique Trudel: 5 shared papers
Louis Bherer and Julien Cohen-Adad: 5 shared papers
Louis Bherer and Julien Cohen-Adad: 5 shared papers
Julien Cohen-Adad and Louis Bherer: 5 shared papers
Dominique Trudel and Frederic Leblond: 5 shared papers
Dominique Trudel and Frederic Leblond: 5 shared papers
Frédéric Lesage and Jean-Claude Tardif: 4 shared papers
Frédéric Lesage and Jean-Claude Tardif: 4 shared papers
Dang Nguyen and Dang Nguyen: 4 shared papers
Jean-Claude Tardif and Frédéric Lesage: 4 shared papers
Jean-Claude Tardif and Guillaume Marquis-Gravel: 4 shared papers
Jean-Claude Tardif and Frédéric Lesage: 4 shared papers
Jean-Claude Tardif and Guillaume Marquis-Gravel: 4 shared papers
Frédéric Lesage and Frederic Leblond: 3 shared papers
Frédéric Lesage and Frederic Leblond: 3 shared papers
Jean-Claude Tardif and Robert Avram: 3 shared papers
Jean-Claude Tardif and Robert Avram: 3 shared papers
Guy Cloutier and Jean-Claude Tardif: 2 shared papers
Guy Cloutier and Jean-Claude Tardif: 2 shared papers
Frédéric Lesage and Louis Bherer: 2 shared papers
Frédéric Lesage and Louis Bherer: 2 shared papers
Frédéric Lesage and Louis Bherer: 2 shared papers
Guy Cloutier and Frédéric Lesage: 1 shared paper
Frédéric Lesage and Dang Nguyen: 1 shared paper
Frédéric Lesage and Dang Nguyen: 1 shared paper
Frédéric Lesage and Eric Thorin: 1 shared paper
Frédéric Lesage and Julien Cohen-Adad: 1 shared paper
Frédéric Lesage and Eric Thorin: 1 shared paper
Frédéric Lesage and Farida Cheriet: 1 shared paper
Frédéric Lesage and Dominique Trudel: 1 shared paper
Frédéric Lesage and Dominique Trudel: 1 shared paper
Frédéric Lesage and Mohamad Sawan: 1 shared paper
Frédéric Lesage and Anil Nigam: 1 shared paper
Frédéric Lesage and Mohamad Sawan: 1 shared paper
Frédéric Lesage and Angelo Calderone: 1 shared paper
Frédéric Lesage and Guillaume Marquis-Gravel: 1 shared paper
Frédéric Lesage and Elie Bou Assi: 1 shared paper
Frédéric Lesage and Robert Avram: 1 shared paper
Dang Nguyen and Frédéric Lesage: 1 shared paper
Jean-Claude Tardif and Angelo Calderone: 1 shared paper
Dang Nguyen and Frédéric Lesage: 1 shared paper
Jean-Claude Tardif and Angelo Calderone: 1 shared paper
Frédéric Lesage and Farida Cheriet: 1 shared paper

Electrical Engineering
Medicine
Engineering Physics
Neurosciences
Pharmacologie - Physiologie
Chemical Engineering
Neurology and Neurosurgery
Other

Co-authors at Polytechnique Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Jean-Claude Tardif

Chemical Engineering

4 shared papers, latest 2024

Frederic Leblond

Engineering Physics

3 shared papers, latest 2022

Louis Bherer

Neurology and Neurosurgery

2 shared papers, latest 2022

Dominique Trudel

Engineering Physics

1 shared papers, latest 2019

Mohamad Sawan

Electrical Engineering

1 shared papers, latest 2011

Mohamad Sawan

Neurosciences

1 shared papers, latest 2011

Angelo Calderone

Physiology and Pharmacology

1 shared papers, latest 2019

Dang Nguyen

Neurosciences

1 shared papers, latest 2011

Sarah Fraser

Interdisciplinary Health Sciences

1 shared papers, latest 2022

Dang Nguyen

Electrical Engineering

1 shared papers, latest 2011

Guy Cloutier

Radiology & Imaging

1 shared papers, latest 2016

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2023

Subject: Prospective PhD student: Optical Coherence Tomography Dear Professor Lesage, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Deep learning-based prediction of diffusion MRI responses from microvascular OCT angiograms." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Ultrafast microscopy and network modeling to underpin microvascular driven brain damage." (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Frédéric Lesage

Research

Latest papers

Latest funding

Deep learning-based prediction of diffusion MRI responses from microvascular OCT angiograms.

Improving microvascular brain analysis with adversarial learning for OCT-TPM vascular domain translation.

Chitosan siRNA Nanoparticles Produce Significant Non-Toxic Functional Gene Silencing in Kidney Cortices.

Evaluation of stenoses using AI video models applied to coronary angiography.

Exploring cognitive and brain oxygenation changes over a 1-year period in physically active individuals with mild cognitive impairment: a longitudinal fNIRS pilot study.

Time-gated interferometric detection increases Raman scattering to fluorescence signal ratio in biological samples.

A simulation study investigating potential diffusion-based MRI signatures of microstrokes.

Large-Scale Desynchronization During Interictal Epileptic Discharges Recorded With Intracranial EEG.

Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation.

More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction.

Ultrasound Localization Microscopy of Single-Capillary Reporter Dynamics in Experimental Stroke

Ultrafast microscopy and network modeling to underpin microvascular driven brain damage.

Vascular Optical Imaging

Improving epilepsy diagnosis through machine learning-based interpretation of routine electroencephalography recordings

Dynamic Ultrasound Localization Pulsatility Imaging

Integrated time-domain micro-optode to facilitate long-term clinical NIRS

Improving the identification of retinal biomarkers of Alzheimer disease in vivo

Ultrafast optical coherence tomography algorithms for real-time processing**********

Bridging the scales: Modeling macroscopic imaging from microscopy

Design of a bracelet embedding high-frequency ultrasound transducers to acquire venous blood echogenicity spectral data for patient monitoring

Frequent collaborators