Thomas Gervais, Polytechnique Montréal

Research

Capillary flows Drug discovery Ex vivo assays Fluid mechanics Mass transport Mathematical modeling Microfluidics Personalized medicine

Latest papers

Mass fabrication of PDMS microfluidic devices by injection molding and applications in sensitive 3D spheroid and explant culture.
Scientific reports · 2025 · senior author
Single cell level analysis of ATP release kinetics and cell fate following ultrasound targeted microbubble cavitation using microscopy techniques.
PloS one · 2025
The 2D microfluidics cookbook - modeling convection and diffusion in plane flow devices.
Lab on a chip · 2023 · senior author

All 15 publications

Latest funding

Raman spectroscopy platform integrating highly sensitive photonic devices, nanostructured surfaces and machine learning for on-site detection of multiple diseases
NSERC · 2023 · Co-investigator
$914,333
High throughput liquid handling platform using open-space microfluidics
NSERC · 2023 · Principal investigator
$150,000
Unveiling the metabolic cooperation via glycerol and lactate as the driver of aggressive prostate cancer using microfluidics and mathematical modeling
SSHRC · 2022 · Principal investigator
$125,000

All 10 grants and awards

15 publications.

01

Mass fabrication of PDMS microfluidic devices by injection molding and applications in sensitive 3D spheroid and explant culture.

Filion R, St-Georges-Robillard A, Chaudoir H, Ritch S, Ndongo M, Chua XY, Laurent E, Mes-Masson AM, Ajji A, Gervais T

Scientific reports2025Senior author

DOI: 10.1038/s41598-025-16863-z PMID: 41006408

02

Single cell level analysis of ATP release kinetics and cell fate following ultrasound targeted microbubble cavitation using microscopy techniques.

Amate M, Tan JJ, Boudreault F, Grygorczyk R, Gervais T, Yu FTH

PloS one2025

DOI: 10.1371/journal.pone.0319318 PMID: 40424275

03

The 2D microfluidics cookbook - modeling convection and diffusion in plane flow devices.

Boulais E, Gervais T

Lab on a chip2023Senior author

DOI: 10.1039/d2lc01033j PMID: 36884010

04

Pixelated Microfluidics for Drug Screening on Tumour Spheroids and Ex Vivo Microdissected Tumour Explants.

Dorrigiv D, Goyette PA, St-Georges-Robillard A, Mes-Masson AM, Gervais T

Cancers2023Senior author

DOI: 10.3390/cancers15041060 PMID: 36831403

05

Multiplexed Viability Assays for High-Throughput Screening of Spheroids of Multiple Sizes.

Marimuthu M, Gervais T

Methods in molecular biology (Clifton, N.J.)2023Senior author

DOI: 10.1007/978-1-0716-3052-5_28 PMID: 37142939

06

Radiotherapy on-chip: microfluidics for translational radiation oncology.

Chermat R, Ziaee M, Mak DY, Refet-Mollof E, Rodier F, Wong P, Carrier JF, Kamio Y, Gervais T

Lab on a chip2022Senior author

DOI: 10.1039/d2lc00177b PMID: 35477748

07

Large-Scale Dried Reagent Reconstitution and Diffusion Control Using Microfluidic Self-Coalescence Modules.

Gervais T, Temiz Y, Aubé L, Delamarche E

Small (Weinheim an der Bergstrasse, Germany)2022First author

DOI: 10.1002/smll.202105939 PMID: 35307960

08

Cell Death Analysis in Cancer Spheroids from a Microfluidic Device.

Lafontaine J, Refet-Mollof E, Najyb O, Gervais T, Wong P

Methods in molecular biology (Clifton, N.J.)2022

DOI: 10.1007/978-1-0716-2553-8_2 PMID: 36087255

09

Microdissected Tissue vs Tissue Slices-A Comparative Study of Tumor Explant Models Cultured On-Chip and Off-Chip.

Dorrigiv D, Simeone K, Communal L, Kendall-Dupont J, St-Georges-Robillard A, Péant B, Carmona E, Mes-Masson AM, Gervais T

Cancers2021Senior author

DOI: 10.3390/cancers13164208 PMID: 34439362

10

Long-term fluorescence hyperspectral imaging of on-chip treated co-culture tumour spheroids to follow clonal evolution.

St-Georges-Robillard A, Cahuzac M, Péant B, Fleury H, Lateef MA, Ricard A, Sauriol A, Leblond F, Mes-Masson AM, Gervais T

Integrative biology : quantitative biosciences from nano to macro2019Senior author

DOI: 10.1093/intbio/zyz012 PMID: 31172192

Raman spectroscopy platform integrating highly sensitive photonic devices, nanostructured surfaces and machine learning for on-site detection of multiple diseases

Co-investigatorNSERC2023Alliance Grants

Principal investigators: Leblond, Frederic F

Keywords: biofluids; biomedical engineering; infectious diseases; machine learning; metrology; molecular assay; nanomaterials; oncology; optics; raman spectroscopy

$914,333

High throughput liquid handling platform using open-space microfluidics

Principal investigatorNSERC2023Research Tools and Instruments

Principal investigators: Gervais, Thomas

$150,000

Unveiling the metabolic cooperation via glycerol and lactate as the driver of aggressive prostate cancer using microfluidics and mathematical modeling

Principal investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Gervais, Thomas

Keywords: Lab-on-a-chip; microfluidics; prostate cancer; ex vivo tumor models; spheroids; hypoxia; glucose metabolism; glycerol shunt; metabolic pathways; urology

$125,000

Unveiling the metabolic cooperation via glycerol and lactate as the driver of aggressive prostate cancer using microfluidics and mathematical modeling

Principal investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Gervais, Thomas

Keywords: Lab-on-a-chip microfluidics prostate cancer ex vivo tumor models spheroids hypoxia glucose metabolism glycerol shunt metabolic pathways urology

$125,000

Lab-on-chip testing ex vivo tumors treated with non-thermal plasma

Co-investigatorSSHRC2021New Frontiers in Research Fund - Special Call

Principal investigators: Wong, Philip

Keywords: Lab-on-Chip Microfluidic Breast Cancer Sarcoma Plasma Medicine Radiotherapy Non-Thermal Plasma

$237,970

Advanced reagent delivery systems for microfluidics

Principal investigatorNSERC2020DND/NSERC Discovery Grant Supplement

Principal investigators: Gervais, Thomas

$120,000

Sciences & médias : l'essentiel pour des communications réussies

Principal investigatorNSERC2020Science Communication Skills Grant

Principal investigators: Gervais, Thomas

$20,000

Advanced reagent delivery systems for microfluidics

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Gervais, Thomas

Keywords: microfluidics; tissue-on-chip; spheroids; fluid mechanics; capillary flows; personalized medicine; mass transport; drug discovery; mathematical modeling; ex vivo assays

$234,000

Electrospray-Differential Mobility Analysis System for the Analysis of Biomacromolecules, Polymeric (Bio)Materials and Nanoparticles

Co-investigatorNSERC2014Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Buschmann, Michael

$149,560

Open microfluidics platforms for the in vitro assessment of drug transport in microtumour samples

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Gervais, Thomas

$180,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Génie physique
Génie chimique
Biomedical Engineering
Other

Co-authors at Polytechnique Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Abdellah AJJI

Génie chimique

1 shared papers, latest 2025

David Juncker

Biomedical Engineering

1 shared papers, latest 2015

Francis Rodier

Faculty

1 shared papers, latest 2022

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2023

Subject: Prospective PhD student: Capillary flows Dear Professor Gervais, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Mass fabrication of PDMS microfluidic devices by injection molding and applications in sensitive 3D spheroid and explant culture." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "High throughput liquid handling platform using open-space microfluidics" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Thomas Gervais

Research

Latest papers

Latest funding

Mass fabrication of PDMS microfluidic devices by injection molding and applications in sensitive 3D spheroid and explant culture.

Single cell level analysis of ATP release kinetics and cell fate following ultrasound targeted microbubble cavitation using microscopy techniques.

The 2D microfluidics cookbook - modeling convection and diffusion in plane flow devices.

Pixelated Microfluidics for Drug Screening on Tumour Spheroids and Ex Vivo Microdissected Tumour Explants.

Multiplexed Viability Assays for High-Throughput Screening of Spheroids of Multiple Sizes.

Radiotherapy on-chip: microfluidics for translational radiation oncology.

Large-Scale Dried Reagent Reconstitution and Diffusion Control Using Microfluidic Self-Coalescence Modules.

Cell Death Analysis in Cancer Spheroids from a Microfluidic Device.

Microdissected Tissue vs Tissue Slices-A Comparative Study of Tumor Explant Models Cultured On-Chip and Off-Chip.

Long-term fluorescence hyperspectral imaging of on-chip treated co-culture tumour spheroids to follow clonal evolution.

Raman spectroscopy platform integrating highly sensitive photonic devices, nanostructured surfaces and machine learning for on-site detection of multiple diseases

High throughput liquid handling platform using open-space microfluidics

Unveiling the metabolic cooperation via glycerol and lactate as the driver of aggressive prostate cancer using microfluidics and mathematical modeling

Unveiling the metabolic cooperation via glycerol and lactate as the driver of aggressive prostate cancer using microfluidics and mathematical modeling

Lab-on-chip testing ex vivo tumors treated with non-thermal plasma

Advanced reagent delivery systems for microfluidics

Sciences & médias : l'essentiel pour des communications réussies

Advanced reagent delivery systems for microfluidics

Electrospray-Differential Mobility Analysis System for the Analysis of Biomacromolecules, Polymeric (Bio)Materials and Nanoparticles

Open microfluidics platforms for the in vitro assessment of drug transport in microtumour samples

Frequent collaborators

Anne-Marie Mes-Masson

Philip Wong

Abdellah AJJI

David Juncker

Ryszard Grygorczyk

Francis Rodier