Faculty profile
Barbara Papadopoulou
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Research
Latest papers
CRISPR-Cas13b mediated gene knockdowns in Leishmania infantum.
International journal for parasitology. Drugs and drug resistance · 2025
Novel insights into the Leishmania infantum transcriptome diversity of protein-coding and non-coding sequences in both stages of parasite development using nanopore direct RNA sequencing.
BMC genomics · 2025 · senior author
Evolutionary divergent clusters of transcribed extinct truncated retroposons drive low mRNA expression and developmental regulation in the protozoan Leishmania.
BMC biology · 2024 · senior author
Latest funding
- $499,800
Prevention of the immunopathology induced by SARS-CoV-2
CIHR · 2021 · Principal investigator
- $1,028,925
Deciphering new concepts of posttranscriptional regulation central to the biology of the human intracellular pathogen Leishmania
CIHR · 2021 · Nominated PI
- $100,000
Deciphering new concepts of posttranscriptional regulation central to the biology of the human intracellular pathogen Leishmania
CIHR · 2021 · Nominated PI
54 publications.
CRISPR-Cas13b mediated gene knockdowns in Leishmania infantum.
Queffeulou M, Fakhfakh R, Fani F, Dos Santos A, Reis Ferreira G, Bigot S, Godin C, Leprohon P, Papadopoulou B, Ouellette M
Novel insights into the Leishmania infantum transcriptome diversity of protein-coding and non-coding sequences in both stages of parasite development using nanopore direct RNA sequencing.
Emond-Rheault JG, Ferreira GR, Lavoie-Ouellet C, Smith MA, Papadopoulou B
Evolutionary divergent clusters of transcribed extinct truncated retroposons drive low mRNA expression and developmental regulation in the protozoan Leishmania.
Ferreira GR, Emond-Rheault JG, Alves L, Leprohon P, Smith MA, Papadopoulou B
Distinctive features of the oropharyngeal microbiome in Inuit of Nunavik and correlations of mild to moderate bronchial obstruction with dysbiosis.
Flahaut M, Leprohon P, Pham NP, Gingras H, Bourbeau J, Papadopoulou B, Maltais F, Ouellette M
Leishmania infantum NTPDase1 and NTPDase2 play an important role in infection and nitric oxide production in macrophages.
da Silva W, Ribeiro IC, Agripino JM, da Silva VHF, de Souza LÂ, Oliveira TA, Bressan GC, Vasconcellos RS, Dumas C, Pelletier J, Sévigny J, Papadopoulou B, Fietto JLR
Identification of novel proteins and mRNAs differentially bound to the Leishmania Poly(A) Binding Proteins reveals a direct association between PABP1, the RNA-binding protein RBP23 and mRNAs encoding ribosomal proteins.
Assis LA, Santos Filho MVC, da Cruz Silva JR, Bezerra MJR, de Aquino IRPUC, Merlo KC, Holetz FB, Probst CM, Rezende AM, Papadopoulou B, da Costa Lima TDC, de Melo Neto OP
Genetic depletion of the RNA helicase DDX3 leads to impaired elongation of translating ribosomes triggering co-translational quality control of newly synthesized polypeptides.
Padmanabhan PK, Ferreira GR, Zghidi-Abouzid O, Oliveira C, Dumas C, Mariz FC, Papadopoulou B
The AAA + ATPase valosin-containing protein (VCP)/p97/Cdc48 interaction network in Leishmania.
Aguiar BG, Dumas C, Maaroufi H, Padmanabhan PK, Papadopoulou B
New insights in the mode of action of anti-leishmanial drugs by using chemical mutagenesis screens coupled to next-generation sequencing.
Bhattacharya A, Bigot S, Padmanabhan PK, Mukherjee A, Coelho A, Leprohon P, Papadopoulou B, Ouellette M
In Vivo Tethering System to Isolate RNA-Binding Proteins Regulating mRNA Decay in Leishmania.
Azizi H, Papadopoulou B
Prevention of the immunopathology induced by SARS-CoV-2
Principal investigators: Estaquier, Jérôme; Baz Etchebarne, Mariana; Droit, Arnaud; Papadopoulou, Barbara
Keywords: Biomarker; Caspase; Cell Death; Hamster; Inflammation; Interferon; Omics; Pathogenesis; Sars-Cov-2; Therapy
Deciphering new concepts of posttranscriptional regulation central to the biology of the human intracellular pathogen Leishmania
Principal investigators: Papadopoulou, Barbara
Keywords: 'Omics' Technologies; 3'Utr Regulatory Elements; Intracellular Parasitism And Pathogenesis; Leishmania; Mrna Decay; Post-Transcriptional Gene Regulation; Ribosome-Associated Quality Control; Rna-Binding Proteins; Rna-Protein Interactions; Translation Regulation
Deciphering new concepts of posttranscriptional regulation central to the biology of the human intracellular pathogen Leishmania
Principal investigators: Papadopoulou, Barbara
Keywords: 'Omics' Technologies; 3'Utr Regulatory Elements; Intracellular Parasitism And Pathogenesis; Leishmania; Mrna Decay; Posttranscriptional Gene Regulation; Ribosome-Associated Quality Control; Rna-Binding Proteins; Rna-Protein Interactions; Translational Control
Post-transcriptional regulatory networks coordinating developmental gene expression in the human pathogen Leishmania
Principal investigators: Papadopoulou, Barbara
Keywords: 3'-Untranslated Regions; Crispr/Cas9; Gene Regulation; Leishmania; Mrna Decay; Protein Immunoprecipitation/Mass Spectrometry; Rna Immunoprecipitation (Rip)-Seq; Rna Regulons; Rna-Binding Proteins; Rna-Seq
The role of eIF2alpha phosphorylation in controlling intracellular development of Leishmania
Principal investigators: Papadopoulou, Barbara
Complex RNA regulatory networks in the human pathogen Leishmania and their role in developmental gene expression and pathogenesis
Principal investigators: Papadopoulou, Barbara
Keywords: 3'Utr Elements; Developmental Gene Regulation; Leishmania; Microarrays; Mrna Decay; Pathogenesis; Proteomics; Rna Regulatory Networks; Rna Sequencing; Rna Structure
Canadian Network for Vaccines and Immunotherapeutics of Cancer and Chronic Viral Diseases (CANVAC) (2006 Renewal Competition)
Principal investigators: Sekaly, RafickPierre
Protoemics: In-gel automated digester and MALDI-TOF spotter
Principal investigators: Poirier, Guy
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Barbara Papadopoulou and Marc Ouellette: 20 shared papers
- Guy Boivin and Jacques Corbeil: 9 shared papers
- Jacques Corbeil and Marc Ouellette: 9 shared papers
- Barbara Papadopoulou and Jacques Corbeil: 3 shared papers
- Guy Boivin and Barbara Papadopoulou: 2 shared papers
- Jérôme Estaquier and Barbara Papadopoulou: 1 shared paper
- Jean Bourbeau and Barbara Papadopoulou: 1 shared paper
- Jean Bourbeau and Marc Ouellette: 1 shared paper
- Microbiologie et immunologie
- Molecular Medicine
- Pediatrics
- Medicine
- Other
Co-authors at Université Laval, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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