Laetitia Michou, Université Laval

Research

Paget'S Disease Of Bone Bone Anabolic Treatment Bone Biomarkers Budget Impact Model Clinical Utility Clinical Validity Drug Safety Health Economic Evaluation

Latest papers

Cardiovascular risk is increased in patients with Paget's disease of bone: Insights from the CARTaGENE cohort.
Bone · 2026 · senior author
Site-specific inverse associations between FGF23 levels and marrow adiposity content at the proximal femur in post-menopausal women.
Bone · 2026
Temporal trends of all-cause mortality in Paget’s disease of bone: a population-based retrospective cohort study over 20 yr
JBMR Plus · 2025 · first author

All 16 publications

Latest funding

Early Bone Fragility as a Marker of Cardiovascular Risk in the Bone-Vascular Axis
CIHR · 2026 · Co-investigator
$180,000
Multifaceted Intervention using Telehealth to Reduce the risk of Falls and Fractures in Older Men (MisterFit study): a Pilot Study
CIHR · 2021 · Co-investigator
$459,765
Clinical validity and clinical utility of a screening test for Paget's disease of bone
CIHR · 2018 · Nominated PI
$100,000

All 8 grants and awards

16 publications.

01

Cardiovascular risk is increased in patients with Paget's disease of bone: Insights from the CARTaGENE cohort.

Champagne C, Vachey C, Dufour A, Morin SN, Goupil R, Agharazii M, Mac-Way F, Michou L

Bone2026Senior author

DOI: 10.1016/j.bone.2026.118031 PMID: 42501928

02

Site-specific inverse associations between FGF23 levels and marrow adiposity content at the proximal femur in post-menopausal women.

Paccou J, Badr S, Ramdane N, Michou L, Courbon G, Mentaverri R

Bone2026

DOI: 10.1016/j.bone.2026.117813 PMID: 41619894

03

Temporal trends of all-cause mortality in Paget’s disease of bone: a population-based retrospective cohort study over 20 yr

Michou L, Gamache P, Rochette L, Dialahy IZ, Guertin JR, Tarride J-E, Brown JP, Jean S

JBMR Plus20251 citationsFirst author

DOI: 10.1093/jbmrpl/ziaf175

04

MYLKFLNB and DOCK1LAMA2 gene-gene interactions associated with rheumatoid arthritis in the focal adhesion pathway.

Veyssiere M, Rodriguez Ordonez MDP, Chalabi S, Michou L, Cornelis F, Boland A, Olaso R, Deleuze JF, Petit-Teixeira E, Chaudru V

Frontiers in genetics2024

DOI: 10.3389/fgene.2024.1375036 PMID: 38803542

05

Prevalence and incidence of Paget's disease of bone: Temporal trend over 20 years in the province of Quebec, Canada

Michou L, Gamache P, Guertin JR, Tarride J-E, Brown JP, Jean S

Bone202313 citationsFirst author

DOI: 10.1016/j.bone.2023.116895

06

Breast Cancer and Microcalcifications: An Osteoimmunological Disorder?

Clemenceau A, Michou L, Diorio C, Durocher F

International journal of molecular sciences2020

DOI: 10.3390/ijms21228613 PMID: 33203195

07

Clinical peripheral enthesitis in the DESIR prospective longitudinal axial spondyloarthritis cohort.

Nadon V, Moltó A, Etcheto A, Bessette L, Michou L, D'Agostino MA, Claudepierre P, Wendling D, Haraoui P, Dougados M

Clinical and experimental rheumatology2019

PMID: 30620273

08

A novel nonsense variant in SUPT20H gene associated with Rheumatoid Arthritis identified by Whole Exome Sequencing of multiplex families.

Veyssiere M, Perea J, Michou L, Boland A, Caloustian C, Olaso R, Deleuze JF, Cornelis F, Petit-Teixeira E, Chaudru V

PloS one2019

DOI: 10.1371/journal.pone.0213387 PMID: 30845214

09

Effects of Biliopancreatic Diversion on Bone Turnover Markers and Association with Hormonal Factors in Patients with Severe Obesity.

Turcotte AF, Grenier-Larouche T, Ung RV, Simonyan D, Carreau AM, Carpentier AC, Mac-Way F, Michou L, Tchernof A, Biertho L, Lebel S, Marceau S, Gagnon C

Obesity surgery2019

DOI: 10.1007/s11695-018-3617-x PMID: 30478790

10

High bone mass in adults.

Paccou J, Michou L, Kolta S, Debiais F, Cortet B, Guggenbuhl P

Joint bone spine2018

DOI: 10.1016/j.jbspin.2018.01.007 PMID: 29407041

Early Bone Fragility as a Marker of Cardiovascular Risk in the Bone-Vascular Axis

Co-investigatorCIHR2026Project Grant

Principal investigators: Mac-Way, Fabrice

Keywords: Bone Fragility; Bone-Vascular Axis; Cardiovascular Disease; Chronic Kidney Disease

$180,000

Multifaceted Intervention using Telehealth to Reduce the risk of Falls and Fractures in Older Men (MisterFit study): a Pilot Study

Co-investigatorCIHR2021Project Grant

Principal investigators: Morin, Suzanne N; Giangregorio, Lora Marie

Keywords: Behavior Change; Bisphosphonate; Exercise; Falls; Fractures; Men; Osteoporosis; Pilot Rct; Telehealth

$459,765

Clinical validity and clinical utility of a screening test for Paget's disease of bone

Nominated PICIHR2018Project Grant - PA: MSK, Skin and Oral Health: Clinical Research - MSK Health

Principal investigators: Michou, Laetitia N

Keywords: Bone Anabolic Treatment; Bone Biomarkers; Budget Impact Model; Clinical Utility; Clinical Validity; Drug Safety; Health Economic Evaluation; Molecular Test; Osteoporosis; Paget'S Disease Of Bone

$100,000

Gene-environment interactions in a chronic bone disease

Nominated PICIHR2013Catalyst Grant: Environments, Genes and Chronic Disease

Principal investigators: Michou, Laetitia N; Jean, Sonia

Keywords: Ambient Air Pollutants; Biomarkers Of Environmental Exposure; Cadmium; Chronic Metabolic Bone Disorders; Gene Expression; Gene Methylation; Geographic Variations In Incidence; Heavy Metals; Paget'S Disease Of Bone; Sqstm1 Mutation

$100,000

Clinical and molecular heterogeneity of Paget's disease of Bone

Nominated PICIHR2013Operating Grant

Principal investigators: Michou, Laetitia N

Keywords: Autophagy; Bone Remodeling; Bone Resorption; Clinical Phenotype; Functional Analysis; Measles Virus Nucleocapsid Protein; Optineurin Gene; Osteoclastic Phenotype; Paget'S Disease Of Bone; Sqstm1/P392l Mutation

$607,390

Involvement of PDB3 and PDB4-related genes in bone diseases

Nominated PICIHR2011Operating Grant

Principal investigators: Michou, Laetitia N

Keywords: Alternative Splicing; Bone Resorption; Gene Expression; Metabolic Bone Diseases; Mutation; Osteoclast; Osteoclast Survival; Paget'S Disease Of Bone; Somatic Mosaicism; Sqstm1/P62 Protein

$336,733

Identification of rare genetic variants in Paget's disease of bone

Nominated PICIHR2010Catalyst Grant: Bone Health

Principal investigators: Michou, Laetitia N

Keywords: Allele Frequency; Candidate Gene; Common Genetic Variants; Founder Effect; Genetic Association Study; Metabolic Bone Disease; Paget'S Disease Of Bone; Rare Genetic Variants; Resequencing; Segregation Analysis

$100,000

Involvement of PDB3 and PDB4-related genes in bone diseases

Nominated PICIHR2010Operating Grant - PA: Musculoskeletal Health, Arthritis, Skin and Oral Health

Principal investigators: Michou, Laetitia N

Keywords: Alternative Splicing; Bone Resorption; Gene Expression; Metabolic Bone Diseases; Mutation; Osteoclast; Osteoclast Survival; Osteopetrosis; Paget'S Disease Of Bone; Sqstm1/P62 Protein

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Médecine
Health Research Methods, Evidence, and Impact
Social and Preventive Medicine
Microbiologie et immunologie
Molecular Medicine
Other

Co-authors at Université Laval, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Sonia Jean

Médecine

3 shared papers, latest 2025

Fabrice Mac-Way

Medicine

2 shared papers, latest 2026

Jean-Eric Tarride

Health Research Methods, Evidence, and Impact

2 shared papers, latest 2025

Francine Durocher

Molecular Medicine

1 shared papers, latest 2020

Caroline Diorio

Social and Preventive Medicine

1 shared papers, latest 2020

Mohsen Agharazii

Medicine

1 shared papers, latest 2026

Laurent Biertho

Faculty

1 shared papers, latest 2019

Claudia Gagnon

Medicine

1 shared papers, latest 2019

Eric Boilard

Microbiologie et immunologie

1 shared papers, latest 2013

Write to this professor

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Applying for

Paper to mention

Subject: Prospective PhD student: Paget'S Disease Of Bone Dear Professor Michou, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Cardiovascular risk is increased in patients with Paget's disease of bone: Insights from the CARTaGENE cohort." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Laetitia Michou

Research

Latest papers

Latest funding

Cardiovascular risk is increased in patients with Paget's disease of bone: Insights from the CARTaGENE cohort.

Site-specific inverse associations between FGF23 levels and marrow adiposity content at the proximal femur in post-menopausal women.

Temporal trends of all-cause mortality in Paget’s disease of bone: a population-based retrospective cohort study over 20 yr

MYLK*FLNB and DOCK1*LAMA2 gene-gene interactions associated with rheumatoid arthritis in the focal adhesion pathway.

Prevalence and incidence of Paget's disease of bone: Temporal trend over 20 years in the province of Quebec, Canada

Breast Cancer and Microcalcifications: An Osteoimmunological Disorder?

Clinical peripheral enthesitis in the DESIR prospective longitudinal axial spondyloarthritis cohort.

A novel nonsense variant in SUPT20H gene associated with Rheumatoid Arthritis identified by Whole Exome Sequencing of multiplex families.

Effects of Biliopancreatic Diversion on Bone Turnover Markers and Association with Hormonal Factors in Patients with Severe Obesity.

High bone mass in adults.

Frequent collaborators

Sonia Jean

Fabrice Mac-Way

Jean-Eric Tarride

Francine Durocher

Caroline Diorio

Mohsen Agharazii

Laurent Biertho

Claudia Gagnon

Eric Boilard

MYLKFLNB and DOCK1LAMA2 gene-gene interactions associated with rheumatoid arthritis in the focal adhesion pathway.