Mohamed Chahine, Université Laval

Research

Cardiac Arrhythmias Ion Channels Heart Patch Clamp Electrophysiology Biomedical Myotonic Dystrophy Type 1 Optical Mapping

Latest papers

A multi-approaches examination of toxicological effects of a naturally-occurring plant alkaloid veratridine, and the synthetic type II pyrethroid lambda-cyhalothrin on honey bees.
Environmental toxicology and pharmacology · 2026
Cardiac organoids bridge translational gaps in 3R-compliant safety testing.
Stem cell research · 2026 · senior author
Generation of a lymphoblastoid-derived induced pluripotent stem cell line (CBRCULi021-A) from a healthy donor for disease modeling.
Stem cell research · 2026 · senior author

All 112 publications

Latest funding

Canada Research Chair - Tier 1
CIHR · 2024 · Nominated PI
$1,400,000
New mechanisms linking voltage-gated sodium channels to structural heart disease
CIHR · 2024 · Nominated PI
$1,151,325
Ant venom peptides as potential inhibitors for peripheral nerve sodium channels
NSERC · 2023 · Principal investigator
$25,000

All 14 grants and awards

112 publications.

01

A multi-approaches examination of toxicological effects of a naturally-occurring plant alkaloid veratridine, and the synthetic type II pyrethroid lambda-cyhalothrin on honey bees.

Kadala A, Charreton M, Pélissier M, Mutterer J, Chahine M, Charnet P, Collet C

Environmental toxicology and pharmacology2026

DOI: 10.1016/j.etap.2026.105121 PMID: 42570684

02

Cardiac organoids bridge translational gaps in 3R-compliant safety testing.

Jajkiewicz C, Chahine M

Stem cell research2026Senior author

DOI: 10.1016/j.scr.2026.104039 PMID: 42364506

03

Generation of a lymphoblastoid-derived induced pluripotent stem cell line (CBRCULi021-A) from a healthy donor for disease modeling.

Jajkiewicz C, Chahine M

Stem cell research2026Senior author

DOI: 10.1016/j.scr.2026.104020 PMID: 42235368

04

Therapeutic Strategies Targeting the Molecular Pathogenesis of Myotonic Dystrophy Type 1: Current Status and Future Directions.

Chahine M, Ginjupalli VKM, Jauvin D, Boutjdir M

Molecular diagnosis & therapy2026First author

DOI: 10.1007/s40291-026-00848-3 PMID: 41996006

05

Revisiting viral reprogramming: Measles virus as a robust platform for high-quality iPSC generation.

Moutaoufik MT, Chahine M

Molecular therapy. Advances2026Senior author

DOI: 10.1016/j.omta.2026.201759 PMID: 42222355

06

Antisense-mediated gene therapy targeting DMPK restores cardiac ion channel function and electrical stability in myotonic dystrophy type 1.

Pierre M, Sourisseau F, Jauvin D, Pouliot V, Carrer M, Jafar-Nejad P, Boutjdir M, Chahine M

Heart rhythm2026Senior author

DOI: 10.1016/j.hrthm.2026.06.003 PMID: 42248312

07

Modeling myotonic dystrophy type 1 with hiPSCs-derived cardiac organoids reveals key disease mechanisms.

Jajkiewicz C, Pouliot V, Chahine M

Heart rhythm2026Senior author

DOI: 10.1016/j.hrthm.2026.02.013 PMID: 41720436

08

C-Terminus of Cav1.3 L-Type Ca2+ Channel Upregulates Its Own Gene Expression.

Sleiman Y, Srivastava U, Reisqs JB, Wadgaonkar R, Qu YS, Pouliot V, Chahine M, Boutjdir M

Cells2026

DOI: 10.3390/cells15090828 PMID: 42121929

09

MBNL2 dysfunction in outer radial glial cells is associated with disrupted corticogenesis in congenital myotonic dystrophy.

De Serres-Bérard T, Gosztyla ML, Nguyen G, Yeo GW, Puymirat J, Chahine M

Neurobiology of disease2026Senior author

DOI: 10.1016/j.nbd.2026.107305 PMID: 41644016

10

Prepulse facilitation of the honeybee CaV4 channel is produced by a shift in channel activation and requires an intact inactivation sequence.

Cens T, Rousset M, Menard C, Chahine M, Collet C, Sandoz JC, Chavanieu A, Estaran S, Thibaud JB, Bois P, Charnet P

The Journal of general physiology2026

DOI: 10.1085/jgp.202413712 PMID: 41665635

Canada Research Chair - Tier 1

Nominated PICIHR2024Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Chahine, Mohamed

Keywords: Cr

$1,400,000

New mechanisms linking voltage-gated sodium channels to structural heart disease

Nominated PICIHR2024Project Grant

Principal investigators: Chahine, Mohamed

Keywords: Biomedical

$1,151,325

Ant venom peptides as potential inhibitors for peripheral nerve sodium channels

Principal investigatorNSERC2023Alliance Grants

Principal investigators: Chahine, Mohamed M

Keywords: Ant venom; Electrophysiology; Ion channels; Nav1.7; Nav1.8; Pain; Patch-clamp; Peptide toxins; Toxins; Voltgae-gated sodium channels

$25,000

Characterization of honeybee inward rectifier potassium (Kir) channels and their sensitivity to insecticides

Principal investigatorNSERC2022Alliance Grants

Principal investigators: Chahine, Mohamed M

$25,000

Mechanisms of heart rhythm disorders and therapeutic interventions in myotonic dystrophy type 1

Nominated PICIHR2020Project Grant

Principal investigators: Chahine, Mohamed

Keywords: Cardiac Arrhythmias; Electrophysiology; Heart; Ion Channels; Myotonic Dystrophy Type 1; Optical Mapping; Patch Clamp; Pluripotent Stem Cells

$1,063,350

Apis mellifera ion channels and tools to study agroecosystems contaminants

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: CHAHINE, Mohamed

$216,000

Investigating the role of gating pore current in cardiac arrhythmias associated with dilated cardiomyopathy

Nominated PICIHR2016Project Grant

Principal investigators: Chahine, Mohamed

Keywords: Cardiac Arrhythmias; Dilated Cardiomyopathy; Electrophysiology; Gating Pore Currents; Ion Channels; Nav1.5; Transgenic Animals; Voltage-Gated Sodium Channels

$1,032,750

Toxicological sensitivity of honeybee ion channels: A molecular approach

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Chahine, Mohamed

$225,000

Toxicological sensitivity of honeybee sodium channels: A molecular approach

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Chahine, Mohamed

$26,000

Beta arrestin mediated dopamine signaling for psychiatric drugs discovery

Co-investigatorCIHR2014Operating Grant

Principal investigators: Beaulieu, Martin

Keywords: Akt/Gsk3; Antipsychotics; Arrestin; Cell Signaling; Dopamine; Gpcr; Lithium; Monoamine; Mood Stabilizers; Sodium Chanels

$913,885

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Other

Co-authors at Université Laval, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Georges Levesque

Faculty

1 shared papers, latest 2010

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Cardiac Arrhythmias Dear Professor Chahine, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A multi-approaches examination of toxicological effects of a naturally-occurring plant alkaloid veratridine, and the synthetic type II pyrethroid lambda-cyhalothrin on honey bees." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Canada Research Chair - Tier 1" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Mohamed Chahine

Research

Latest papers

Latest funding

A multi-approaches examination of toxicological effects of a naturally-occurring plant alkaloid veratridine, and the synthetic type II pyrethroid lambda-cyhalothrin on honey bees.

Cardiac organoids bridge translational gaps in 3R-compliant safety testing.

Generation of a lymphoblastoid-derived induced pluripotent stem cell line (CBRCULi021-A) from a healthy donor for disease modeling.

Therapeutic Strategies Targeting the Molecular Pathogenesis of Myotonic Dystrophy Type 1: Current Status and Future Directions.

Revisiting viral reprogramming: Measles virus as a robust platform for high-quality iPSC generation.

Antisense-mediated gene therapy targeting DMPK restores cardiac ion channel function and electrical stability in myotonic dystrophy type 1.

Modeling myotonic dystrophy type 1 with hiPSCs-derived cardiac organoids reveals key disease mechanisms.

C-Terminus of Cav1.3 L-Type Ca2+ Channel Upregulates Its Own Gene Expression.

MBNL2 dysfunction in outer radial glial cells is associated with disrupted corticogenesis in congenital myotonic dystrophy.

Prepulse facilitation of the honeybee CaV4 channel is produced by a shift in channel activation and requires an intact inactivation sequence.

Canada Research Chair - Tier 1

New mechanisms linking voltage-gated sodium channels to structural heart disease

Ant venom peptides as potential inhibitors for peripheral nerve sodium channels

Characterization of honeybee inward rectifier potassium (Kir) channels and their sensitivity to insecticides

Mechanisms of heart rhythm disorders and therapeutic interventions in myotonic dystrophy type 1

Apis mellifera ion channels and tools to study agroecosystems contaminants

Investigating the role of gating pore current in cardiac arrhythmias associated with dilated cardiomyopathy

Toxicological sensitivity of honeybee ion channels: A molecular approach

Toxicological sensitivity of honeybee sodium channels: A molecular approach

Beta arrestin mediated dopamine signaling for psychiatric drugs discovery

Frequent collaborators

Yves De Koninck

Abid Oueslati

Georges Levesque