Hua Gu, Université de Montréal

Research

Germinal Center Tfh Cells Antibody Affinity Maturation B Cell Lymphoma B Cell Signaling Hematopoiesis And Hematopoietic Stem Cells Leukemia Cbl And Cblb

Latest papers

UBE2F impedes CD8 T cell memory.
The Journal of experimental medicine · 2026 · senior author
Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation.
Immunity · 2024 · senior author
Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells.
Frontiers in immunology · 2021 · senior author

All 7 publications

Latest funding

Molecular mechanisms controlling Tfh cell biology
CIHR · 2026 · Nominated PI
$1,147,500
Developing a vaccine enhancer to enhance pan-viral vaccination
CIHR · 2024 · Nominated PI
$1,044,225
B cell intrinsic mechanisms of the germinal centre reaction
CIHR · 2021 · Nominated PI
$952,426

All 7 grants and awards

7 publications.

01

UBE2F impedes CD8 T cell memory.

Zhong L, Gu H

The Journal of experimental medicine2026Senior author

DOI: 10.1084/jem.20260995 PMID: 42329285

02

Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation.

Li X, Sun W, Huang M, Gong L, Zhang X, Zhong L, Calderon V, Bian Z, He Y, Suh WK, Li Y, Song T, Zou Y, Lian ZX, Gu H

Immunity2024Senior author

DOI: 10.1016/j.immuni.2024.04.023 PMID: 38761804

03

Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells.

Tong H, Li X, Zhang J, Gong L, Sun W, Calderon V, Zhang X, Li Y, Gadzinski A, Langdon WY, Reizis B, Zou Y, Gu H

Frontiers in immunology2021Senior author

DOI: 10.3389/fimmu.2021.757231 PMID: 34630435

04

Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing.

Li X, Gong L, Meli AP, Karo-Atar D, Sun W, Zou Y, King IL, Gu H

The Journal of experimental medicine2020Senior author

DOI: 10.1084/jem.20191537 PMID: 32584413

05

Regulation of immune system development and function by Cbl-mediated ubiquitination.

Li X, Gong L, Gu H

Immunological reviews2019Senior author

DOI: 10.1111/imr.12789 PMID: 31402498

06

Hippo Pathway Kinase Mst1 Is Required for Long-Lived Humoral Immunity.

Bagherzadeh Yazdchi S, Witalis M, Meli AP, Leung J, Li X, Panneton V, Chang J, Li J, Nutt SL, Johnson RL, Lim DS, Gu H, King IL, Suh WK

Journal of immunology (Baltimore, Md. : 1950)2019

DOI: 10.4049/jimmunol.1701407 PMID: 30478091

07

Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.

Li X, Gadzinsky A, Gong L, Tong H, Calderon V, Li Y, Kitamura D, Klein U, Langdon WY, Hou F, Zou YR, Gu H

Immunity2018Senior author

DOI: 10.1016/j.immuni.2018.03.006 PMID: 29562201

Molecular mechanisms controlling Tfh cell biology

Nominated PICIHR2026Project Grant

Principal investigators: Gu, Hua

Keywords: Cbl And Cblb; G Protein Coupled Receptors; Germinal Center Reaction; Lupus And Sle; Tfh Cells

$1,147,500

Developing a vaccine enhancer to enhance pan-viral vaccination

Nominated PICIHR2024Project Grant

Principal investigators: Gu, Hua

Keywords: Antibody Response; Covid19 Virus; Germinal Center; Hiv Virus; Influenza Virus; Memory B Cells; Tfeb; Vaccine

$1,044,225

B cell intrinsic mechanisms of the germinal centre reaction

Nominated PICIHR2021Project Grant

Principal investigators: Gu, Hua

Keywords: Antibody Affinity Maturation; B Cell Lymphoma; B Cell Signaling; Germinal Center; Ubiquitination And Lysosome Biogenesis

$952,426

Molecular mechanisms controlling T follicular helper (TFH) cell biology

Nominated PICIHR2019Project Grant

Principal investigators: Gu, Hua

Keywords: Autoimmunity; Germinal Center; Protein Ubiquitination And Degradation; Tfh Cell Signaling; Tfh Cells

$726,750

B cell intrinsic mechanisms of germinal center reaction

Nominated PICIHR2015Operating Grant

Principal investigators: Gu, Hua

Keywords: Antibody Affinity Maturation; B Cell Lymphoma; B Cell Signaling; Germinal Center

$732,000

MicroRNA regulation of normal and malignant hematopoietic stem cell biology

Nominated PICIHR2012China-Canada Joint Health Research Initiative

Principal investigators: Gu, Hua; Fei, Jian

Keywords: Animal Models; Hematopoiesis And Hematopoietic Stem Cells; Leukemia; Microrna; Mirna; Mouse Models

$225,000

MicroRNA regulation of hematopoietic stem cell biology and leukemia

Nominated PICIHR2012Operating Grant - PA: Cancer Research (bridge funding)

Principal investigators: Gu, Hua

Keywords: Hematopoiesis And Hematopoietic Stem Cells; Leukemia

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Molecular Immunology
Epidemiology and Biostatistics
Other

Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Yue Li

Epidemiology and Biostatistics

2 shared papers, latest 2021

Woong-Kyung Suh

Faculty

2 shared papers, latest 2024

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2026

Subject: Prospective PhD student: Germinal Center Dear Professor Gu, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "UBE2F impedes CD8 T cell memory." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Molecular mechanisms controlling Tfh cell biology" (2026), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]