Faculty profile
Lucie Parent
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Research
Latest papers
A Novel Gain-of-Function CACNA1C Variant (Gly856Asp) Associated With QT Prolongation and Sudden Death.
JACC. Case reports · 2025 · senior author
Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel.
IUBMB life · 2023
A CACNA1C variant associated with cardiac arrhythmias provides mechanistic insights in the calmodulation of L-type Ca2+ channels.
The Journal of biological chemistry · 2022 · senior author
Latest funding
- $104,000
Calmodulation of ion channels
NSERC · 2023 · Principal investigator
- $738,226
Molecular, Cellular, and Subunit-dependent Regulation of Voltage-Gated Calcium Channels
CIHR · 2018 · Nominated PI
- $168,000
Structural biology of calcium channels
NSERC · 2017 · Principal investigator
15 publications.
A Novel Gain-of-Function CACNA1C Variant (Gly856Asp) Associated With QT Prolongation and Sudden Death.
Tadros R, Zhao J, Leduc C, Bouron-Dal Soglio D, Fournier A, Parent L
Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel.
Al-Katat A, Bergeron A, Parent L, Lorenzini M, Fiset C, Calderone A
A CACNA1C variant associated with cardiac arrhythmias provides mechanistic insights in the calmodulation of L-type Ca2+ channels.
Zhao J, Segura E, Marsolais M, Parent L
Sympathetic Stimulation Upregulates the Ca2+ Channel Subunit, CaVα2δ1, via the β1 and ERK 1/2 Pathway in Neonatal Ventricular Cardiomyocytes.
Al Katat A, Zhao J, Calderone A, Parent L
Novel Gain-of-Function Variant in CACNA1C Associated With Timothy Syndrome, Multiple Accessory Pathways, and Noncompaction Cardiomyopathy.
Kelu Bisabu K, Zhao J, Mokrane AE, Segura É, Marsolais M, Grondin S, Naas E, Gagnon J, Cadrin-Tourigny J, Aguilar M, Mongeon FP, Talajic M, Parent L, Tadros R
An ancestral MAGUK protein supports the modulation of mammalian voltage-gated Ca2+ channels through a conserved CaVβ-like interface.
Segura E, Mehta A, Marsolais M, Quan XR, Zhao J, Sauvé R, Spafford JD, Parent L
A three-way inter-molecular network accounts for the CaVα2δ1-induced functional modulation of the pore-forming CaV1.2 subunit.
Briot J, Mailhot O, Bourdin B, Tétreault MP, Najmanovich R, Parent L
Negatively charged residues in the first extracellular loop of the L-type CaV1.2 channel anchor the interaction with the CaVα2δ1 auxiliary subunit.
Bourdin B, Briot J, Tétreault MP, Sauvé R, Parent L
Proteolytic cleavage of the hydrophobic domain in the CaVα2δ1 subunit improves assembly and activity of cardiac CaV1.2 channels.
Segura E, Bourdin B, Tétreault MP, Briot J, Allen BG, Mayer G, Parent L
A helical segment makes potassium channels go-go.
Parent L
Calmodulation of ion channels
Principal investigators: Parent, Lucie
Keywords: calcium; electrophysiology; ion channels; molecular dynamics; protein interaction; regulation; structure
Molecular, Cellular, and Subunit-dependent Regulation of Voltage-Gated Calcium Channels
Principal investigators: Parent, Lucie
Keywords: Cardiac Hypertrophy; Heart Failure; Ion Channel; Regulation Of Ion Channel Function; Structural Biology
Structural biology of calcium channels
Principal investigators: Parent, Lucie
Robot for lipidic cubic phase (LCP) crystallization of membrane proteins
Principal investigators: Baron, Christian
Trafficking of L-type calcium channel Cav1.2 in cardiomyocytes
Principal investigators: Parent, Lucie
Keywords: Calcium; Electrophysiology/Patch-Clamp; Endocytosis; Fret; Imaging; Ion Channel; Neonate Cardiomyocytes; Rab Proteins; Targeting; Western Blots
Molecular determinants of voltage-dependent gating in T-type calcium channels
Principal investigators: Parent, Lucie
Relations structure-fonction des transporteurs epitheliaux
Principal investigators: Parent, Lucie
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Rafik Tadros and Julia Cadrin-Tourigny: 55 shared papers
- Anne Fournier and Rafik Tadros: 9 shared papers
- Stanley Nattel and Rafik Tadros: 7 shared papers
- Anne Fournier and Julia Cadrin-Tourigny: 7 shared papers
- Stanley Nattel and Julia Cadrin-Tourigny: 4 shared papers
- Lucie Parent and Rafik Tadros: 2 shared papers
- Lucie Parent and Céline Fiset: 1 shared paper
- Lucie Parent and Stanley Nattel: 1 shared paper
- Lucie Parent and Anne Fournier: 1 shared paper
- Lucie Parent and Julia Cadrin-Tourigny: 1 shared paper
- Céline Fiset and Stanley Nattel: 1 shared paper
- Pharmacologie - Physiologie
- Centre de recherche
- Medicine
- Other
Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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