Mohamed Benderdour

Research

Analogues Apoptosis Bone Fpr2 Human Mice Osteoblast Osteoclast

Latest papers

Trehalose as an anti-inflammatory agent: insights into molecular mechanisms and therapeutic applications.
Inflammopharmacology · 2026
Protective Effect of Resolvin D1, D2, and Their Methyl Esters on Oxidative Stress and Hyaluronidase-Induced Hyaluronic Acid Degradation.
Antioxidants (Basel, Switzerland) · 2026 · senior author
Preclinical Mechanistic Evaluation of Hyaluronan/Niacinamide (Vitamin B3) Hydrogels: Toward an Enhanced Viscosupplement System with Ancillary Anti-Arthritic Attributes.
Bioengineering (Basel, Switzerland) · 2025

All 41 publications

Latest funding

Development of novel RvD1 analogues for osteoporosis therapy: mechanism of action and structure-activity relationships
CIHR · 2022 · Nominated PI
$100,000
The lipid peroxidation product 4-hydroxynonenal in the pathophysiology of osteoarthritis
CIHR · 2013 · Nominated PI
$100,000
Protein modification by 4-hydroxynonenal (HNE) modulates cell function: identification of specific proteins as cellular targets of HNE binding
NSERC · 2010 · Principal investigator
$135,000

All 4 grants and awards

41 publications.

01

Trehalose as an anti-inflammatory agent: insights into molecular mechanisms and therapeutic applications.

Radbakhsh S, Benderdour M, Maanani Y, Fernandes JC, Sahebkar A, Fahmi H

Inflammopharmacology2026

DOI: 10.1007/s10787-026-02181-x PMID: 41807879

02

Protective Effect of Resolvin D1, D2, and Their Methyl Esters on Oxidative Stress and Hyaluronidase-Induced Hyaluronic Acid Degradation.

Kariminezhad Z, Rahimi M, Fernandes J, Fahmi H, Benderdour M

Antioxidants (Basel, Switzerland)2026Senior author

DOI: 10.3390/antiox15020163 PMID: 41750543

03

Preclinical Mechanistic Evaluation of Hyaluronan/Niacinamide (Vitamin B3) Hydrogels: Toward an Enhanced Viscosupplement System with Ancillary Anti-Arthritic Attributes.

Hadjab F, Antoine S, Hamel B, Benderdour M, Fahmi H, Porcello A, Philippe V, Martin R, Marques C, Lourenço K, Scaletta C, Hirt-Burri N, Abdel-Sayed P, Applegate LA, Laurent AE

Bioengineering (Basel, Switzerland)2025

DOI: 10.3390/bioengineering12111246 PMID: 41301202

04

Chitosan nanovectors for siRNA delivery: New horizons for nonviral gene therapy.

Rahimi M, Kariminezhad Z, Rondon EP, Fahmi H, Fernandes JC, Benderdour M

Carbohydrate polymers2025Senior author

DOI: 10.1016/j.carbpol.2025.123581 PMID: 40399008

05

RNA Modifications in Osteoarthritis: Epitranscriptomic Insights into Pathogenesis and Therapeutic Targets.

Radbakhsh S, Najar M, Merimi M, Benderdour M, Fernandes JC, Martel-Pelletier J, Pelletier JP, Fahmi H

International journal of molecular sciences2025

DOI: 10.3390/ijms26104955 PMID: 40430096

06

Lymphocyte transformation test reveals low prevalence of true metal hypersensitivity among pre-operative total knee arthroplasty patients.

Boutefnouchet T, Vallières F, Delisle J, Benderdour M, Fernandes JC

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2022

DOI: 10.1007/s00167-022-06951-2 PMID: 35380240

07

Impact of Degree of Ionization and PEGylation on the Stability of Nanoparticles of Chitosan Derivatives at Physiological Conditions.

Martinez Junior AM, Lima AMF, Martins GO, Tiera VAO, Benderdour M, Fernandes JC, Tiera MJ

Marine drugs2022

DOI: 10.3390/md20080476 PMID: 35892944

08

Chitosan-Based Nanogels: Synthesis and Toxicity Profile for Drug Delivery to Articular Joints.

Manivong S, Garcia Ac A, Patten SA, Fernandes JC, Benderdour M, Banquy X, Moldovan F, Roullin VG

Nanomaterials (Basel, Switzerland)2022

DOI: 10.3390/nano12081337 PMID: 35458048

09

Identification of 4-hydroxynonenal-modified proteins in human osteoarthritic chondrocytes.

Geib T, Iacob C, Jribi R, Fernandes J, Benderdour M, Sleno L

Journal of proteomics2021

DOI: 10.1016/j.jprot.2020.104024 PMID: 33122130

10

L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis.

Ouhaddi Y, Najar M, Paré F, Lussier B, Urade Y, Benderdour M, Pelletier JP, Martel-Pelletier J, Fahmi H

Aging2020

DOI: 10.18632/aging.202367 PMID: 33361529

Development of novel RvD1 analogues for osteoporosis therapy: mechanism of action and structure-activity relationships

Nominated PICIHR2022Project Grant - PA: Institute of Musculoskeletal Health and Arthritis: Pain

Principal investigators: Benderdour, Mohamed

Keywords: Analogues; Apoptosis; Bone; Fpr2; Human; Mice; Osteoblast; Osteoclast; Osteoporosis; Rvd1

$100,000

The lipid peroxidation product 4-hydroxynonenal in the pathophysiology of osteoarthritis

Nominated PICIHR2013Operating Grant - PA: Musculoskeletal Health, Arthritis, Skin and Oral Health

Principal investigators: Benderdour, Mohamed

Keywords: 4-Hydroxynonenal; Acetylation; Cartilage; Dh404; Glutathione-S-Transferase; Nrf2; Osteoarthritis; Sirt2; Srt1720

$100,000

Protein modification by 4-hydroxynonenal (HNE) modulates cell function: identification of specific proteins as cellular targets of HNE binding

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Benderdour, Mohamed

$135,000

Cationic polymeric nanovectors for plasmid DNA and siRNA delivery in experimental arthritis and bone fracture treatments.

Co-investigatorCIHR2009Team Grant: China-Canada Collaborative Teams in Health Research

Principal investigators: Fernandes, Julio C; Dai, Kerong

Keywords: Arthritis; Bone Fracture; Chitosan And Polyethyleneimide; Polymeric Nanoparticles; Sirna And Gene Therapy

$500,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Centre de recherche
Surgery
Stomatologie
Orthopedics
Other

Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Florina Moldovan

Stomatologie

2 shared papers, latest 2022

Xavier Banquy

Faculty

1 shared papers, latest 2022

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Analogues Dear Professor Benderdour, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Trehalose as an anti-inflammatory agent: insights into molecular mechanisms and therapeutic applications." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Development of novel RvD1 analogues for osteoporosis therapy: mechanism of action and structure-activity relationships" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Mohamed Benderdour

Research

Latest papers

Latest funding

Trehalose as an anti-inflammatory agent: insights into molecular mechanisms and therapeutic applications.

Protective Effect of Resolvin D1, D2, and Their Methyl Esters on Oxidative Stress and Hyaluronidase-Induced Hyaluronic Acid Degradation.

Preclinical Mechanistic Evaluation of Hyaluronan/Niacinamide (Vitamin B3) Hydrogels: Toward an Enhanced Viscosupplement System with Ancillary Anti-Arthritic Attributes.

Chitosan nanovectors for siRNA delivery: New horizons for nonviral gene therapy.

RNA Modifications in Osteoarthritis: Epitranscriptomic Insights into Pathogenesis and Therapeutic Targets.

Lymphocyte transformation test reveals low prevalence of true metal hypersensitivity among pre-operative total knee arthroplasty patients.

Impact of Degree of Ionization and PEGylation on the Stability of Nanoparticles of Chitosan Derivatives at Physiological Conditions.

Chitosan-Based Nanogels: Synthesis and Toxicity Profile for Drug Delivery to Articular Joints.

Identification of 4-hydroxynonenal-modified proteins in human osteoarthritic chondrocytes.

L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis.

Development of novel RvD1 analogues for osteoporosis therapy: mechanism of action and structure-activity relationships

The lipid peroxidation product 4-hydroxynonenal in the pathophysiology of osteoarthritis

Protein modification by 4-hydroxynonenal (HNE) modulates cell function: identification of specific proteins as cellular targets of HNE binding

Cationic polymeric nanovectors for plasmid DNA and siRNA delivery in experimental arthritis and bone fracture treatments.

Frequent collaborators

Hassan Fahmi

Johanne Martel-Pelletier

Mohit Kapoor

Mohit Kapoor

Mohit Kapoor

Florina Moldovan

Xavier Banquy