Daniel Lafontaine

Research

Antibacterial Compounds Cotranscriptional Processes Folding Dynamics Genetic Regulation Riboswitches Rna Polymerase Rna Structure Rna-Metabolite Interaction

Latest papers

The yeast telomerase module for telomere recruitment requires a specific RNA architecture.
RNA (New York, N.Y.) · 2018
Purine analogs targeting the guanine riboswitch as potential antibiotics against Clostridioides difficile.
European journal of medicinal chemistry · 2018
Regulatory RNAs and target mRNA decay in prokaryotes.
Biochimica et biophysica acta · 2013

All 3 publications

Latest funding

A new camera to monitor RNA dynamics from transcription to regulation
NSERC · 2025 · Principal investigator
$117,751
Monitoring RNA structural dynamics from transcription to gene regulation, one molecule at the time
CIHR · 2022 · Nominated PI
$722,926
Study of riboswitch regulatory mechanisms in Escherichia coli
NSERC · 2020 · Principal investigator
$300,000

All 20 grants and awards

3 publications.

01

The yeast telomerase module for telomere recruitment requires a specific RNA architecture.

Laterreur N, Lemieux B, Neumann H, Berger-Dancause JC, Lafontaine D, Wellinger RJ

RNA (New York, N.Y.)2018

DOI: 10.1261/rna.066696.118 PMID: 29777050

02

Purine analogs targeting the guanine riboswitch as potential antibiotics against Clostridioides difficile.

Yan LH, Le Roux A, Boyapelly K, Lamontagne AM, Archambault MA, Picard-Jean F, Lalonde-Seguin D, St-Pierre E, Najmanovich RJ, Fortier LC, Lafontaine D, Marsault É

European journal of medicinal chemistry2018

DOI: 10.1016/j.ejmech.2017.11.079 PMID: 29220796

03

Regulatory RNAs and target mRNA decay in prokaryotes.

Lalaouna D, Simoneau-Roy M, Lafontaine D, Massé E

Biochimica et biophysica acta2013

DOI: 10.1016/j.bbagrm.2013.02.013 PMID: 23500183

A new camera to monitor RNA dynamics from transcription to regulation

Principal investigatorNSERC2025Research Tools and Instruments

Principal investigators: Lafontaine, Daniel

Keywords: rna; structure; fonction; folding; single-molecule fret; real-time; elongation complexes; co-transcriptional; rna-protein interactions; rna-rna interactions

$117,751

Monitoring RNA structural dynamics from transcription to gene regulation, one molecule at the time

Nominated PICIHR2022Project Grant

Principal investigators: Lafontaine, Daniel

Keywords: Antibacterial Compounds; Cotranscriptional Processes; Folding Dynamics; Genetic Regulation; Riboswitches; Rna Polymerase; Rna Structure; Rna-Metabolite Interaction; Single Molecule Approaches; Translation Initiation

$722,926

Study of riboswitch regulatory mechanisms in Escherichia coli

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Lafontaine, Daniel

$300,000

Acquisition of a Fluorescence and Chemiluminescence Imaging Platform

Co-investigatorNSERC2020Research Tools and Instruments

Principal investigators: Maréchal, Alexandre

$53,588

DNA genetic analyzer for molecular ecology/biology applications

Co-investigatorNSERC2019Research Tools and Instruments

Principal investigators: Garant, Dany

$149,515

Importance of transcriptional pausing in bacterial riboswitch regulation

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Lafontaine, Daniel

$36,000

The 19th Annual Meeting of the RiboClub

Co-investigatorCIHR2018Planning and Dissemination Grant - Institute Community Support

Principal investigators: Scott, Michelle

Keywords: Epigenetics And Rna Modification; High-Throughput Technologies; Molecular Biology Of Rna; Non-Coding Rnas; Post-Transcriptional Gene Regulation; Ribosome And Translation Regulation; Rna Biology In Diseases; Rna Degradation; Rna-Seq; Systems Biology And Rna Networks

$20,000

The Annual Riboclub Symposium

Co-investigatorCIHR2017Planning and Dissemination Grant - Institute Community Support

Principal investigators: Massé, Eric

Keywords: Molecular Biology Of Rna; Non-Coding Rnas; Post-Transcriptional Gene Regulation; Rna Biology In Diseases; Rna-Binding Proteins

$10,000

Acquisition of an in vivo imaging system

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Gévry, Nicolas

$144,824

Acquisition of a liquid scintillation counter

Principal investigatorNSERC2016Research Tools and Instruments

Principal investigators: Lafontaine, Daniel

$52,434

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Louis-Charles Fortier

Microbiology and Infectious Diseases

1 shared papers, latest 2018

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2025

Subject: Prospective PhD student: Antibacterial Compounds Dear Professor Lafontaine, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The yeast telomerase module for telomere recruitment requires a specific RNA architecture." (2018), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "A new camera to monitor RNA dynamics from transcription to regulation" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]