Faculty profile
Léon Sanche
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Research
Latest papers
Integrating Biochemical and Computational Approaches Reveal Structural Insights in Trastuzumab scFv-Fc Antibody Engineering.
Biomolecules · 2025
How a Single 5 eV Electron Can Induce Double-Strand Breaks in DNA: A Time-Dependent Density Functional Theory Study.
The journal of physical chemistry. B · 2024 · senior author
Chemical transformation of molecular ices containing N2O and C2D2 by low energy electrons: New chemical species of astronomical interest.
The Journal of chemical physics · 2021 · senior author
Latest funding
- $69,000
Nanoscopic aspects of cellular radiation chemistry: Role of low energy electrons
NSERC · 2024 · Principal investigator
- $320,000
Low-energy electron induced processes in radiation damage: relationship to astrochemistry, radiobiology and radiotherapy
NSERC · 2019 · Principal investigator
- $634,950
Secondary electron collision cross sections for micro- and nano-dosimetry of emerging radiation and chemo-radiation therapies.
CIHR · 2018 · Nominated PI
4 publications.
Integrating Biochemical and Computational Approaches Reveal Structural Insights in Trastuzumab scFv-Fc Antibody Engineering.
Bednova O, Pougoue Ketchemen J, Mslati H, Barok M, Joensuu H, Zeytuni N, Gentile F, Sanche L, Fonge H, Leyton JV
How a Single 5 eV Electron Can Induce Double-Strand Breaks in DNA: A Time-Dependent Density Functional Theory Study.
Kumar A, Sevilla MD, Sanche L
Chemical transformation of molecular ices containing N2O and C2D2 by low energy electrons: New chemical species of astronomical interest.
Mirsaleh-Kohan N, Esmaili S, Bass AD, Huels MA, Sanche L
Loss of cellular transformation efficiency induced by DNA irradiation with low-energy (10 eV) electrons.
Kouass Sahbani S, Sanche L, Cloutier P, Bass AD, Hunting DJ
Nanoscopic aspects of cellular radiation chemistry: Role of low energy electrons
Principal investigators: Sanche, Léon
Keywords: radiation chemistry; low energy electrons; dna damage; secondary electrons; radiobiology; radiosensitizers; thin dna films; gold nanoparticles; strand breaks; hplc/ms analysis
Low-energy electron induced processes in radiation damage: relationship to astrochemistry, radiobiology and radiotherapy
Principal investigators: Sanche, Léon
Secondary electron collision cross sections for micro- and nano-dosimetry of emerging radiation and chemo-radiation therapies.
Principal investigators: Sanche, Léon
Keywords: Chemoradiation; Dna Radiation Damage; Dose In Radiotherapy; Electron Scattering Cross Sections; Gold Nanoparticles; Low Energy Electrons; Monte Carlo Simulation; Nanodosimetry,; Radionuclide Therapy; Secondary Electrons
Investigations of low energy electron damage to DNA: application to Chemoradiation therapy.
Principal investigators: Sanche, Léon
Keywords: Biomolecular Damage; Biomolecules; Cancer Treatment; Cellular Molecules; Chemoradiation Therapy; Concomitance; Dna Damage; Electron Spectroscopy; Electron Stimulated Desorption; Gold Nanoparticles.; Low Energy Electrons; Radiation Damage; Radiosensitizers; Radiotherapy; Secondary Electrons
Monte Carlo techniques in the optimization of radiation therapy delivery and outcomes
Principal investigators: Seuntjens, Jan P
Keywords: Intra-Operative Radiation Therapy; Medical Physics; Modulated Electron Radiation Therapy; Monte Carlo Radiation Transport; Optimization; Radiation Damage Cross Sections; Radiation Dose Calculations; Radiation Oncology; Radiation Therapy Outcomes; Radiation Track Structure
Low energy electron induced processes of relevance to focused electron beam induced processing, astrobiology and related fields
Principal investigators: Sanche, Léon
Secondary electron collision cross sections for use in radiotherapy and radioprotection/Sections efficaces de diffusion des électrons secondaires pour utilisation en radiothérapie et radioprotection.
Principal investigators: Sanche, Léon
Keywords: Biomolecular Damage; Biomolecules; Cancer Treatment; Cellular Molecules; Chemoradiation Therapy; Dna Damage; Electron Scattering Cross Sections; Electron Spectroscopy; Electron Stimulated Desorption; Electron Trapping; Low Energy Electrons; Mass Spectrometry; Microdosimetry; Modelling Of Radiation Damage; Nanodosimetry; Radiation Damage; Radiosensitizers; Radiotherapy; Secondary Electrons
Développement de composés antinéoplasiques radiosensibilisants acheminés par nano transporteur liposomal.
Principal investigators: Sanche, Léon
Keywords: Composés Platinés; Glioblastome; Nanoparticules D'Or; Radiation; Radiosensibilisant
Investigations of low energy electron damage to cellular constituents: application to Chemoradiation therapy.
Principal investigators: Sanche, Léon
Keywords: Biomolecular Damage; Biomolecules; Cancer Treatment; Cellular Molecules; Chemoradiation Therapy; Concomitance; Dna Damage; Electron Spectroscopy; Electron Stimulated Desorption; Gold Nanoparticles.; Low Energy Electrons; Radiation Damage; Radiosensitizers; Radiotherapy; Secondary Electrons
fundamental investigations of low energy (0-30 eV) electron induced processes for application to nanolithography, ballistic electronic devices and astrobiology
Principal investigators: Sanche, Léon
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Médecine nucléaire et radiobiologie
- Anatomy and Biology
- Other
Co-authors at Université de Sherbrooke, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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