Scot Leary, University of Saskatchewan

Research

Mitochondria Copper Breast Cancer Oncogenes And Tumour Suppressors Targets And Biomarkers Translational Research Bioenergetics Liver

Latest papers

Author Correction: Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models.
Cellular & molecular immunology · 2023
Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models.
Cellular & molecular immunology · 2022

All 2 publications

Latest funding

Disrupting mitochondrial function in the liver: implications for immune suppression
CIHR · 2022 · Nominated PI
$100,000
Targeting mitochondrial fission machinery in tumor-initiating cells
CIHR · 2022 · Nominated PI
$59,609
Molecular mechanism of copper and platinum drug transport in human cells
CIHR · 2021 · Co-investigator
$761,176

All 8 grants and awards

2 publications.

01

Author Correction: Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models.

Huang J, Leary S, Xiang J

Cellular & molecular immunology2023

DOI: 10.1038/s41423-022-00970-2 PMID: 36693923

02

Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models.

Huang J, Leary S, Xiang J

Cellular & molecular immunology2022

DOI: 10.1038/s41423-022-00879-w PMID: 35589987

Disrupting mitochondrial function in the liver: implications for immune suppression

Nominated PICIHR2022Project Grant - PA: Nutrition, Metabolism and Diabetes

Principal investigators: Leary, Scot

Keywords: Bioenergetics; Copper; Liver; Mitochondria; Mitochondrial Diseases; Protein Secretion; Signaling

$100,000

Targeting mitochondrial fission machinery in tumor-initiating cells

Nominated PICIHR2022CIHR - ICR / Cancer Research Society Partnership - Res. Grants - Breast Cancer

Principal investigators: Leary, Scot

Keywords: Breast Cancer; Oncogenes And Tumour Suppressors; Targets And Biomarkers; Translational Research

$59,609

Molecular mechanism of copper and platinum drug transport in human cells

Co-investigatorCIHR2021Project Grant

Principal investigators: Dmitriev, Oleg Y

Keywords: Atox1; Atp7b; Copper Transport; Drug Resistance In Cancer; Membrane Transporter; Metal Transport In The Cell; Platinum Based Chemotherapy

$761,176

Functional genetic investigation of the mitochondrial regulation of copper homeostasis

Nominated PICIHR2013Operating Grant

Principal investigators: Leary, Scot

Keywords: Cell Biology; Cellular Copper Handling; Cox Assembly Factors; Cytochrome C Oxidase (Cox); Genetics; Human Diseases; Metabolism; Mitochondria; Protein Trafficking; Redox Signaling

$639,699

Targeted delivery of copper to mitochondria: investigating its therapeutic potential for the effective treatment of patients with mutations in SCO1 and SCO2

Nominated PICIHR2012Champions of Genetics: Building the Next Generation

Principal investigators: Leary, Scot

Keywords: Copper; Mitochondria

$30,000

Genetic and functional characterization of SCO-dependent, mitochondrial regulation of cellular copper homeostasis

Nominated PICIHR2011Operating Grant - PA: Regional Partnership Program - Saskatchewan

Principal investigators: Leary, Scot

Keywords: Cell Biology; Cellular Copper Handling; Cox Assembly Factors; Cytochrome C Oxidase (Cox); Genetics; Human Diseases; Metabolism; Mitochondria; Protein Trafficking; Redox Signaling

$111,971

Genetic and functional characterization of SCO-dependent, mitochondrial regulation of cellular copper homeostasis

Nominated PICIHR2011New Investigator Salary Award - PA: Regional Partnerships Program - Saskatchewan

Principal investigators: Leary, Scot

Keywords: Cell Biology; Cellular Copper Handling; Cox Assembly Factors; Cytochrome C Oxidase (Cox); Genetics; Human Diseases; Metabolism; Mitochondria; Protein Trafficking; Redox Signaling

$150,000

""Rheostatic"" regulation of mitchondrial volume density: evaluating the relative contributions of synthetic and degradative pathways to total organelle content.

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Leary, Scot

$185,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Jim Xiang

Medical Oncology

2 shared papers, latest 2023

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Mitochondria Dear Professor Leary, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Author Correction: Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Disrupting mitochondrial function in the liver: implications for immune suppression" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Scot Leary

Research

Latest papers

Latest funding

Author Correction: Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPK&#x3b1;1 pathways in linear cell differentiation and asymmetric cell division models.

Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPK&#x3b1;1 pathways in linear cell differentiation and asymmetric cell division models.

Disrupting mitochondrial function in the liver: implications for immune suppression

Targeting mitochondrial fission machinery in tumor-initiating cells

Molecular mechanism of copper and platinum drug transport in human cells

Functional genetic investigation of the mitochondrial regulation of copper homeostasis

Targeted delivery of copper to mitochondria: investigating its therapeutic potential for the effective treatment of patients with mutations in SCO1 and SCO2

Genetic and functional characterization of SCO-dependent, mitochondrial regulation of cellular copper homeostasis

Genetic and functional characterization of SCO-dependent, mitochondrial regulation of cellular copper homeostasis

""Rheostatic"" regulation of mitchondrial volume density: evaluating the relative contributions of synthetic and degradative pathways to total organelle content.

Frequent collaborators

Jim Xiang

Author Correction: Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models.

Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models.