Faculty profile

Jim Xiang

ResearcherOncologyUniversity of Saskatchewan

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Saskatchewan directory, so their courses may be missing. Find their university profile.

Jim Xiang

Researcher

Oncology

University of Saskatchewan

Saskatoon, Saskatchewan, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
12 publications in the last five years, latest in 2026.
Senior (last) author on 9 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (4 NSERC, 4 CIHR), most recently in 2019.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

103

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

bone loss FAK focal adhesions microgravity osteoblast RhoA Wnt Ampk

Latest papers

TGF-β Regulates CD8+ T Cell Memory by Triggering mTORC1Weak-Mediated Activation of the Transcriptional FOXO1-TCF1-Eomes and Metabolic AMPK-ULK1-ATG7 Pathways.
Cells · 2026 · senior author
The 41BB-agonist potentiates the therapeutic efficacy of a combined irreversible electroporation ablation treatment of lung cancer by promoting unexpected CD8+CD103+ cDC1 and tissue-resident memory T cell responses.
Frontiers in immunology · 2025 · senior author
Focal Adhesion Kinase Alleviates Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation by Activating Transcriptional Wnt/β-Catenin-BMP2-COL1 and Metabolic SIRT1-PGC-1α-CPT1A Pathways.
International journal of molecular sciences · 2025 · senior author

All 103 publications

Latest funding

Simulated microgravity blocks osteoblastic differentiation and mineralization leading to bone loss via suppressing the FAK/RhoA-regulated Wnt pathway
NSERC · 2019 · Principal investigator
$216,000
Distinct regulation of T cell fate and memory via differentially IL-2- and IL-7-activated mTORC1-KIF13A-M6PR axis and AMPK-FOXO-Eomes pathway
CIHR · 2016 · Nominated PI
$470,476
Combined late and early HIV-1 protein-specific exosome-targeted T cell-based vaccine capable of stimulating CTL responses in absence of CD4+ T cell help
CIHR · 2012 · Nominated PI
$294,891

All 8 grants and awards

103 publications.

TGF-β Regulates CD8+ T Cell Memory by Triggering mTORC1Weak-Mediated Activation of the Transcriptional FOXO1-TCF1-Eomes and Metabolic AMPK-ULK1-ATG7 Pathways.

Wu Z, Yu M, Leary SC, Yuan J, Huang J, Xiang J

Cells2026Senior author

DOI: 10.3390/cells15050471 PMID: 41827904

The 41BB-agonist potentiates the therapeutic efficacy of a combined irreversible electroporation ablation treatment of lung cancer by promoting unexpected CD8+CD103+ cDC1 and tissue-resident memory T cell responses.

Fang C, Wu Z, Leary SC, Bai Y, Yu M, Baniak N, Ahmed S, Groot G, Moser M, Zhang W, Zhang B, Huang J, Ma H, Feng Y, Xiang J

Frontiers in immunology2025Senior author

DOI: 10.3389/fimmu.2025.1688281 PMID: 41194931

Focal Adhesion Kinase Alleviates Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation by Activating Transcriptional Wnt/β-Catenin-BMP2-COL1 and Metabolic SIRT1-PGC-1α-CPT1A Pathways.

Bai Y, Wu Z, Leary SC, Fang C, Yu M, Genth H, Xie Y, Shi J, Xiang J

International journal of molecular sciences2025Senior author

DOI: 10.3390/ijms26041669 PMID: 40004131

CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8+CD103+ cDC1 and TRM cell responses.

Wu Z, Yang Z, Iftikhar T, Groot G, Leary SC, Baniak N, Ahmed S, Bosch M, Moser M, Zhang W, Jiang J, Xiang J

Cancer immunology, immunotherapy : CII2025Senior author

DOI: 10.1007/s00262-025-04217-7 PMID: 41251836

Molecular basis and pathways of the Yin-Yang theory in T cell immunity.

Xiang J, Leary SC, Wu Z, Yu M

Frontiers in immunology2024First author

DOI: 10.3389/fimmu.2024.1463399 PMID: 39611157

Author Correction: Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models.

Huang J, Leary S, Xiang J

Cellular & molecular immunology2023Senior author

DOI: 10.1038/s41423-022-00970-2 PMID: 36693923

Influenza vaccination-induced H3 stalk-reactive memory B-cell clone expansion.

Long Z, He J, Shuai Q, Zhang K, Xiang J, Wang H, Xie S, Wang S, Du W, Yao X, Huang J

Vaccine2023

DOI: 10.1016/j.vaccine.2022.12.068 PMID: 36621409

Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKα1-ULK1-ATG7 Pathways.

Xu A, Leary SC, Islam MF, Wu Z, Bhanumathy KK, Ara A, Chibbar R, Fleywald A, Ahmed KA, Xiang J

Journal of immunology (Baltimore, Md. : 1950)2022Senior author

DOI: 10.4049/jimmunol.2100452 PMID: 34872976

Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models.

Huang J, Leary S, Xiang J

Cellular & molecular immunology2022Senior author

DOI: 10.1038/s41423-022-00879-w PMID: 35589987

The Critical Role of AMPKα1 in Regulating Autophagy and Mitochondrial Respiration in IL-15-Stimulated mTORC1Weak Signal-Induced T Cell Memory: An Interplay between Yin (AMPKα1) and Yang (mTORC1) Energy Sensors in T Cell Differentiation.

Ara A, Wu Z, Xu A, Ahmed KA, Leary SC, Islam MF, Chibbar R, Wu Y, Xiang J

International journal of molecular sciences2022Senior author

DOI: 10.3390/ijms23179534 PMID: 36076931

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2019

Subject: Prospective PhD student: bone loss Dear Professor Xiang, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "TGF-β Regulates CD8+ T Cell Memory by Triggering mTORC1Weak-Mediated Activation of the Transcriptional FOXO1-TCF1-Eomes and Metabolic AMPK-ULK1-ATG7 Pathways." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Simulated microgravity blocks osteoblastic differentiation and mineralization leading to bone loss via suppressing the FAK/RhoA-regulated Wnt pathway" (2019), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Jim Xiang

Research

Latest papers

Latest funding

TGF-&#x3b2; Regulates CD8+ T Cell Memory by Triggering mTORC1Weak-Mediated Activation of the Transcriptional FOXO1-TCF1-Eomes and Metabolic AMPK-ULK1-ATG7 Pathways.

The 41BB-agonist potentiates the therapeutic efficacy of a combined irreversible electroporation ablation treatment of lung cancer by promoting unexpected CD8+CD103+ cDC1 and tissue-resident memory T cell responses.

Focal Adhesion Kinase Alleviates Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation by Activating Transcriptional Wnt/&#x3b2;-Catenin-BMP2-COL1 and Metabolic SIRT1-PGC-1&#x3b1;-CPT1A Pathways.

CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8+CD103+ cDC1 and TRM cell responses.

Molecular basis and pathways of the Yin-Yang theory in T cell immunity.

Author Correction: Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPK&#x3b1;1 pathways in linear cell differentiation and asymmetric cell division models.

Influenza vaccination-induced H3 stalk-reactive memory B-cell clone expansion.

Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPK&#x3b1;1-ULK1-ATG7 Pathways.

Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPK&#x3b1;1 pathways in linear cell differentiation and asymmetric cell division models.

The Critical Role of AMPK&#x3b1;1 in Regulating Autophagy and Mitochondrial Respiration in IL-15-Stimulated mTORC1Weak Signal-Induced T Cell Memory: An Interplay between Yin (AMPK&#x3b1;1) and Yang (mTORC1) Energy Sensors in T Cell Differentiation.

Simulated microgravity blocks osteoblastic differentiation and mineralization leading to bone loss via suppressing the FAK/RhoA-regulated Wnt pathway

Distinct regulation of T cell fate and memory via differentially IL-2- and IL-7-activated mTORC1-KIF13A-M6PR axis and AMPK-FOXO-Eomes pathway

Combined late and early HIV-1 protein-specific exosome-targeted T cell-based vaccine capable of stimulating CTL responses in absence of CD4+ T cell help

Acombined early and late HIV-1 protein-specific exosome-targeted T cell vaccine capable of stimulating HIV-1 specific CD8+ CTL responses in absence of CD4+ T cells and counteracting immune suppression.

A combined early and late HIV-1 protein-specific exosome-targeted T cell vaccine capable of counteracting immune supression and stimulating CD8+ CTL responses in absence of CD4+ T cells. A future therapeutic HIV-1 vaccine.

Structure/functional analysis of phage display-derived and molecularly designed loop peptides with high binding affinity for human tumor-specific NeuAc2-6aGal-NAcal-O-Ser

Engineering of antibody affinity and immunogenicity under the guidance of a computational model of B72.3/TAG72 complex

Conformationally constrained recombinant peptides with binding affinity for tumor-specific NeuAca2-6Ga1NAcal-o-Ser

Frequent collaborators

Andrew Freywald

Yangdou Wei

Shahid Ahmed

Wenjun Zhang

Gary Groot

Xulin Guo

Philip Griebel

John Gordon

Sylvia van Drunen Littel-van den Hurk

Scot Leary

Scott Napper

Yuliang Wu

Suresh Tikoo

Yan Zhou

Yue Chen

Qiang Liu

Vikram Misra

Zhou Xing

TGF-β Regulates CD8+ T Cell Memory by Triggering mTORC1Weak-Mediated Activation of the Transcriptional FOXO1-TCF1-Eomes and Metabolic AMPK-ULK1-ATG7 Pathways.

Focal Adhesion Kinase Alleviates Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation by Activating Transcriptional Wnt/β-Catenin-BMP2-COL1 and Metabolic SIRT1-PGC-1α-CPT1A Pathways.

Author Correction: Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models.

Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKα1-ULK1-ATG7 Pathways.

Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models.

The Critical Role of AMPKα1 in Regulating Autophagy and Mitochondrial Respiration in IL-15-Stimulated mTORC1Weak Signal-Induced T Cell Memory: An Interplay between Yin (AMPKα1) and Yang (mTORC1) Energy Sensors in T Cell Differentiation.