Steven Machtaler, University of Saskatchewan

Research

Aptamers Bowel Strictures Inflammation Inflammatory Bowel Disease Microbubbles Ultrasound Molecular Imaging

Latest papers

Chemically-induced trout model of acute intestinal inflammation using TNBS.
Fish and shellfish immunology reports · 2023 · senior author
Contrast-enhanced ultrasound imaging for assessment of intestinal inflammation in rainbow trout.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2023 · senior author
Aptamer-Functionalized Microbubbles Targeted to P-selectin for Ultrasound Molecular Imaging of Murine Bowel Inflammation.
Molecular imaging and biology · 2023 · senior author

All 9 publications

Latest funding

Ultrasound molecular imaging of intestinal stenosis: Developing a contrast agent to distinguish between inflammatory and fibrotic strictures in patients with inflammatory bowel disease
CIHR · 2024 · Nominated PI
$875,925
Tumor targeted, radiolabeled, mimetic nanovesicle theranostics for imaging and treating head and neck cancer
CIHR · 2023 · Co-investigator
$963,900
Development of imaging tools for simultaneous PET-MRI imaging of acute inflammation and fibrosis associated with inflammatory bowel disease.
CIHR · 2022 · Supervisor
$6,000

All 7 grants and awards

9 publications.

01

Chemically-induced trout model of acute intestinal inflammation using TNBS.

Horn ME, Segner H, Brinkmann M, Machtaler S

Fish and shellfish immunology reports2023Senior author

DOI: 10.1016/j.fsirep.2022.100073 PMID: 36605611

02

Contrast-enhanced ultrasound imaging for assessment of intestinal inflammation in rainbow trout.

Horn ME, Brinkmann M, Machtaler S

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP2023Senior author

DOI: 10.1016/j.cbpc.2023.109690 PMID: 37364706

03

Aptamer-Functionalized Microbubbles Targeted to P-selectin for Ultrasound Molecular Imaging of Murine Bowel Inflammation.

Goncin U, Curiel L, Geyer CR, Machtaler S

Molecular imaging and biology2023Senior author

DOI: 10.1007/s11307-022-01755-9 PMID: 35851673

04

SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse Model.

Di Y, Lew J, Goncin U, Radomska A, Rout SS, Gray BET, Machtaler S, Falzarano D, Lavender KJ

Viruses2022

DOI: 10.3390/v14102272 PMID: 36298826

05

Developing a Microbubble-Based Contrast Agent for Synchrotron Multiple-Image Radiography.

Ton N, Goncin U, Panahifar A, Webb MA, Chapman D, Wiebe S, Machtaler S

Molecular imaging and biology2022Senior author

DOI: 10.1007/s11307-022-01705-5 PMID: 35137326

06

Rapid Copper-free Click Conjugation to Lipid-Shelled Microbubbles for Ultrasound Molecular Imaging of Murine Bowel Inflammation.

Goncin U, Bernhard W, Curiel L, Geyer CR, Machtaler S

Bioconjugate chemistry2022Senior author

DOI: 10.1021/acs.bioconjchem.2c00104 PMID: 35427123

07

Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets.

Francis ME, Richardson B, Goncin U, McNeil M, Rioux M, Foley MK, Ge A, Pechous RD, Kindrachuk J, Cameron CM, Richardson C, Lew J, Machtaler S, Cameron MJ, Gerdts V, Falzarano D, Kelvin AA

Scientific reports2021

DOI: 10.1038/s41598-021-93855-9 PMID: 34267262

08

SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney.

Francis ME, Goncin U, Kroeker A, Swan C, Ralph R, Lu Y, Etzioni AL, Falzarano D, Gerdts V, Machtaler S, Kindrachuk J, Kelvin AA

PLoS pathogens2021

DOI: 10.1371/journal.ppat.1009705 PMID: 34265022

09

Contrast-enhanced ultrasound imaging for assessing organ perfusion in rainbow trout (Oncorhynchus mykiss).

Goncin U, Ton N, Reddy A, El Kaffas A, Brinkmann M, Machtaler S

The Science of the total environment2021Senior author

DOI: 10.1016/j.scitotenv.2020.141231 PMID: 33182180

Ultrasound molecular imaging of intestinal stenosis: Developing a contrast agent to distinguish between inflammatory and fibrotic strictures in patients with inflammatory bowel disease

Nominated PICIHR2024Project Grant

Principal investigators: Machtaler, Steven B

Keywords: Aptamers; Bowel Strictures; Inflammation; Inflammatory Bowel Disease; Microbubbles; Ultrasound Molecular Imaging

$875,925

Tumor targeted, radiolabeled, mimetic nanovesicle theranostics for imaging and treating head and neck cancer

Co-investigatorCIHR2023Project Grant

Principal investigators: Price, Eric W; Geyer, Clarence R

Keywords: Bioconjugation Chemistry; Head And Neck Cancer; Mimetic Nanovesicle; Nanoparticles; Positron Emission Tomography; Radioimmunotherapy; Radionuclide Therapy; Targeted Radionuclide Therapy; Theranostics; Zirconium-89

$963,900

Development of imaging tools for simultaneous PET-MRI imaging of acute inflammation and fibrosis associated with inflammatory bowel disease.

SupervisorCIHR2022Canada Graduate Scholarships - Michael Smith Foreign Study Supplements

Principal investigators: Goncin, Una

Keywords: Acute Inflammation; Bowel Disease; Fibrosis; Pet_Mri

$6,000

A cutting-edge mechanical stimulation bioreactor for tissue engineering

Co-investigatorNSERC2020Research Tools and Instruments

Principal investigators: Chen, Xiongbiao

$150,000

Development of imaging tools for simultaneous PET-MRI imaging of acute inflammation and fibrosis associated with inflammatory bowel disease

SupervisorCIHR2020Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Goncin, Una

Keywords: Fibrosis; Inflammation; Inflammatory Bowel Disease; Microdroplets; Molecular Imaging; Mri; Pet; Pet-Mri; Quantitative

$105,000

Determining the biochemical mechanism of microbubble-mediated vascular permeability

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Machtaler, Steven

$217,000

Determining the biochemical mechanism of microbubble-mediated vascular permeability

Principal investigatorNSERC2018Discovery Launch Supplement

Principal investigators: Machtaler, Steven

$12,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medical Imaging
Vaccine and Infectious Disease Organization
Microbiology and Immunology
Other

Co-authors at University of Saskatchewan, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Darryl Falzarano

Vaccine and Infectious Disease Organization

3 shared papers, latest 2022

Volker Gerdts

Faculty

2 shared papers, latest 2021

Christopher Richardson

Microbiology and Immunology

1 shared papers, latest 2021

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Aptamers Dear Professor Machtaler, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Chemically-induced trout model of acute intestinal inflammation using TNBS." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Ultrasound molecular imaging of intestinal stenosis: Developing a contrast agent to distinguish between inflammatory and fibrotic strictures in patients with inflammatory bowel disease" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]