Faculty profile
Troy Harkness
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Research
Latest papers
A rapid, high-throughput method for determining chronological lifespan in budding yeast.
Journal of biological methods · 2018
Metformin inhibits the development, and promotes the resensitization, of treatment-resistant breast cancer.
PloS one · 2017
A short motif in Arabidopsis CDK inhibitor ICK1 decreases the protein level, probably through a ubiquitin-independent mechanism.
The Plant journal : for cell and molecular biology · 2016
Latest funding
- $872,100
Functional dissection of the role of the Anaphase Promoting Complex in cellular longevity
CIHR · 2019 · Nominated PI
- $420,000
Characterization of molecular mechanisms governing budding yeast lifespan using small peptides that interact with the Anaphase Promoting Complex
NSERC · 2017 · Principal investigator
- $200,000
Characterization of genes isolated in a novel screen for mutants with altered mitotic lifespan in yeast
NSERC · 2012 · Principal investigator
4 publications.
A rapid, high-throughput method for determining chronological lifespan in budding yeast.
Belak ZR, Harkness T, Eskiw CH
Metformin inhibits the development, and promotes the resensitization, of treatment-resistant breast cancer.
Davies G, Lobanova L, Dawicki W, Groot G, Gordon JR, Bowen M, Harkness T, Arnason T
A short motif in Arabidopsis CDK inhibitor ICK1 decreases the protein level, probably through a ubiquitin-independent mechanism.
Li Q, Shi X, Ye S, Wang S, Chan R, Harkness T, Wang H
Development, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1.
Arnason T, Harkness T
Functional dissection of the role of the Anaphase Promoting Complex in cellular longevity
Principal investigators: Harkness, Troy A; Arnason, Terra; Eskiw, Christopher H
Keywords: Anaphase Promoting Complex (Apc); Apc Binding And Activating Peptides; Genetics, Biochemistry And Microscopy; Human Progeria Primary Fibroblasts; Longevity; Nutrient Sensing; Protein Stability; Stress Sensing; Yeast; Yeast Progeria Model
Characterization of molecular mechanisms governing budding yeast lifespan using small peptides that interact with the Anaphase Promoting Complex
Principal investigators: Harkness, Troy
Characterization of genes isolated in a novel screen for mutants with altered mitotic lifespan in yeast
Principal investigators: Harkness, Troy
Characterization of a conserved yeast Forkhead Box longevity pathway
Principal investigators: Harkness, Troy A
Keywords: Anaphase Promoting Complex (Apc); Biochemistry; Cell Biology; Cell Cycle Progression; Forkhead Box Transcription Factors; Molecular Biology; Molecular Mechanisms Of Longevity And Stress Response; Molecular Mecnaisms Of Cancer; Nutrient Response Pathways; Signal Transduction; Ubiquitin Targeting; Yeast Genetics
The interplay of yeast kinase pathways with the Anaphase Promoting Complex in the genetics of cell longevity as a factor in aging
Principal investigators: Lindsay, Donna L
Keywords: Aging; Anaphase Promoting Complex; Cell Cycle; Genetics; Longevity; Model Systems; Pathway Mechanisms; Protein Degradation; Sugar Response; Transcription Regulation
Characterization of the Role of Ras2p and Msn2/4p Stress response Transcription Factors in Stress Response and Age Related Signaling
Principal investigators: Sheikh, Amin A
Keywords: Aging And Longevity; Biochemistry; Genetics; Molecular Biology; Multiple Disease Relevance; Yeast
Dynamic chromatin structure controls Anaphase Promoting Complex activity
Principal investigators: Islam, Azharul
Keywords: Apc; Chromatin; Chromatin Dynamics; Chromatin Immunoprecipitation; Gene Expression; Genetic Interactions; H3; H4; Hat; Hdac; Histone Modification; Northern Analysis; Rt-Pcr; Saccharomyces Cerevisiae; Transcription
Analytical epifluorescence microscope
Principal investigators: Kaminskyj, Susan
The role of Rsp5p in the regulation of chromatin metabolism in yeast
Principal investigators: Harkness, Troy
Regulation of chromatin assembly in yeast by the ubiquitin-protein ligase, Rsp5p
Principal investigators: Harkness, Troy
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Biochemistry, Microbiology & Immunology
- Community Health and Epidemiology
Co-authors at University of Saskatchewan, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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