Jack Jhamandas, University of Alberta

Research

Alzheimer'S Disease Amylin Peptide/Receptor Amyloid Protein Behavioural Testing Cellular Neurophysiology Long Term Potentiation (Ltp)Molecular Biology Hippocampus

Latest papers

Author Correction: Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model.
Scientific reports · 2022 · senior author
Extracellular vesicles enriched with amylin receptor are cytoprotective against the Aß toxicity in vitro.
PloS one · 2022 · senior author
Cyanidin-3-O-Glucoside improves the viability of human islet cells treated with amylin or Aβ1-42 in vitro.
PloS one · 2021

All 14 publications

Latest funding

Amylin Receptor: A potential therapeutic target for Alzheimer's disease
CIHR · 2018 · Nominated PI
$443,700
The amylin receptor as a novel therapeutic target for Alzheimer's disease
CIHR · 2016 · Nominated PI
$100,000
Role of beta-amyloid peptides in kainic acid-induced toxicity and its implications in temporal lobe epilepsy
CIHR · 2012 · Co-investigator
$396,335

All 5 grants and awards

14 publications.

01

Author Correction: Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model.

Soudy R, Kimura R, Patel A, Fu W, Kaur K, Westaway D, Yang J, Jhamandas J

Scientific reports2022Senior author

DOI: 10.1038/s41598-022-10922-5 PMID: 35484381

02

Extracellular vesicles enriched with amylin receptor are cytoprotective against the Aß toxicity in vitro.

Soudy R, Kimura R, Fu W, Patel A, Jhamandas J

PloS one2022Senior author

DOI: 10.1371/journal.pone.0267164 PMID: 35421203

03

Cyanidin-3-O-Glucoside improves the viability of human islet cells treated with amylin or Aβ1-42 in vitro.

Croden J, Silva JR, Huang W, Gupta N, Fu W, Matovinovic K, Black M, Li X, Chen K, Wu Y, Jhamandas J, Rayat GR

PloS one2021

DOI: 10.1371/journal.pone.0258208 PMID: 34614009

04

Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model.

Soudy R, Kimura R, Patel A, Fu W, Kaur K, Westaway D, Yang J, Jhamandas J

Scientific reports2019Senior author

DOI: 10.1038/s41598-019-47255-9 PMID: 31358858

05

Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation.

Fu W, Vukojevic V, Patel A, Soudy R, MacTavish D, Westaway D, Kaur K, Goncharuk V, Jhamandas J

Journal of neuroinflammation2017Senior author

DOI: 10.1186/s12974-017-0972-9 PMID: 28985759

06

Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease.

Soudy R, Patel A, Fu W, Kaur K, MacTavish D, Westaway D, Davey R, Zajac J, Jhamandas J

Alzheimer's & dementia (New York, N. Y.)2017Senior author

DOI: 10.1016/j.trci.2016.11.005 PMID: 29067318

07

Synergistic associations of catechol-O-methyltransferase and brain-derived neurotrophic factor with executive function in aging are selective and modified by apolipoprotein E.

Sapkota S, Vergote D, Westaway D, Jhamandas J, Dixon RA

Neurobiology of aging2015

DOI: 10.1016/j.neurobiolaging.2014.06.020 PMID: 25107496

08

APOE and COMT polymorphisms are complementary biomarkers of status, stability, and transitions in normal aging and early mild cognitive impairment.

Dixon RA, DeCarlo CA, MacDonald SW, Vergote D, Jhamandas J, Westaway D

Frontiers in aging neuroscience2014

DOI: 10.3389/fnagi.2014.00236 PMID: 25249975

09

Characterization of the NT2-derived neuronal and astrocytic cell lines as alternative in vitro models for primary human neurons and astrocytes.

Haile Y, Fu W, Shi B, Westaway D, Baker G, Jhamandas J, Giuliani F

Journal of neuroscience research2014

DOI: 10.1002/jnr.23399 PMID: 24801011

10

IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults.

McFall GP, Wiebe SA, Vergote D, Westaway D, Jhamandas J, Dixon RA

Neurobiology of aging2013

DOI: 10.1016/j.neurobiolaging.2013.03.010 PMID: 23597493

Amylin Receptor: A potential therapeutic target for Alzheimer's disease

Nominated PICIHR2018Project Grant

Principal investigators: Jhamandas, Jack H

Keywords: Alzheimer'S Disease; Amylin Peptide/Receptor; Amyloid Protein; Behavioural Testing; Cellular Neurophysiology; Hippocampus; Long Term Potentiation (Ltp); Molecular Biology; Neuroinflammation; Transgenic Mouse Models

$443,700

The amylin receptor as a novel therapeutic target for Alzheimer's disease

Nominated PICIHR2016Project Grant

Principal investigators: Jhamandas, Jack H

Keywords: Alzheimer'S Disease; Amylin Peptide/Receptor; Amyloid Protein; Behavioural Testing; Cellular Neurophysiology; Long Term Potentiation (Ltp); Molecular Biology; Transgenic Mice

$100,000

Role of beta-amyloid peptides in kainic acid-induced toxicity and its implications in temporal lobe epilepsy

Co-investigatorCIHR2012Operating Grant

Principal investigators: Kar, Satyabrata

Keywords: Astrocytes; Beta Amyloid Peptides; Excitotoxicity; Neurodegeneration; Neuroprotection; Temporal Lobe Epilepsy

$396,335

Role of RFamide peptides in CNS cardiovascular regulation

Nominated PICIHR2010Operating Grant-PA: Sodium and Health

Principal investigators: Jhamandas, Jack H

Keywords: Blood Pressure; Electrophysiology; Hypothalamus; Immunohistochemitry; Neuropeptides

$272,313

The human amylin receptor as a target for the actions of amyloid-beta protein in the brain.

Nominated PICIHR2008Operating Grant

Principal investigators: Jhamandas, Jack H

Keywords: Alzheimer'S Disease; Amylin; Amyloid Peptides; Apoptosis; Cellular Neurophysiology; Human Neurons/Transgenics

$839,637

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine/Neurology
Medicine
Other

Co-authors at University of Alberta, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

David Westaway

Medicine

8 shared papers, latest 2022

Christopher Power

Medicine

1 shared papers, latest 2007

Devidas Menon

Faculty

1 shared papers, latest 2011

Fabrizio Giuliani

Medicine/Neurology

1 shared papers, latest 2014

Satyabrata Kar

Medicine/Neurology

1 shared papers, latest 2013

Christopher Power

Medicine/Neurology

1 shared papers, latest 2007

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mention

Subject: Prospective PhD student: Alzheimer'S Disease Dear Professor Jhamandas, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Author Correction: Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model." (2022), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Jack Jhamandas

Research

Latest papers

Latest funding

Author Correction: Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model.

Extracellular vesicles enriched with amylin receptor are cytoprotective against the A&#xdf; toxicity in vitro.

Cyanidin-3-O-Glucoside improves the viability of human islet cells treated with amylin or A&#x3b2;1-42 in vitro.

Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model.

Role of microglial amylin receptors in mediating beta amyloid (A&#x3b2;)-induced inflammation.

Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease.

Synergistic associations of catechol-O-methyltransferase and brain-derived neurotrophic factor with executive function in aging are selective and modified by apolipoprotein E.

APOE and COMT polymorphisms are complementary biomarkers of status, stability, and transitions in normal aging and early mild cognitive impairment.

Characterization of the NT2-derived neuronal and astrocytic cell lines as alternative in vitro models for primary human neurons and astrocytes.

IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults.

Amylin Receptor: A potential therapeutic target for Alzheimer's disease

The amylin receptor as a novel therapeutic target for Alzheimer's disease

Role of beta-amyloid peptides in kainic acid-induced toxicity and its implications in temporal lobe epilepsy

Role of RFamide peptides in CNS cardiovascular regulation

The human amylin receptor as a target for the actions of amyloid-beta protein in the brain.

Frequent collaborators

David Westaway

Christopher Power

Devidas Menon

Fabrizio Giuliani

Satyabrata Kar

Christopher Power

Extracellular vesicles enriched with amylin receptor are cytoprotective against the Aß toxicity in vitro.

Cyanidin-3-O-Glucoside improves the viability of human islet cells treated with amylin or Aβ1-42 in vitro.

Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation.