Faculty profile

David Westaway

ResearcherMedicineUniversity of Alberta

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Alberta directory, so their courses may be missing. Find their university profile.

David Westaway

Researcher

Medicine

University of Alberta

Edmonton, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
15 publications in the last five years, latest in 2026.
Senior (last) author on 7 recent papers, a sign of leading a research group.
Principal investigator on 9 research grants (9 CIHR), most recently in 2020.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Transgenics Prions Protein Folding Tau Frontotemporal Dementia Proteostasis Alzheimer'S Chemical Denaturation

Latest papers

A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation.
Acta neuropathologica · 2026
Expression of progerin enhances disease-related endpoints in a tau seeding reporter cell system.
GeroScience · 2026 · senior author
Microbial Composition, Disease Trajectory and Genetic Background in a Slow Onset Model of Frontotemporal Lobar Degeneration.
Biomolecules · 2025 · senior author

All 68 publications

Latest funding

Diverse disease-associated forms of tau; molecular cell biology and relationships to pathogenesis.
CIHR · 2020 · Nominated PI
$883,576
Intracerebral seeding with misfolded proteins in second generation AD mouse models: Visualizing spread of pathology.
CIHR · 2020 · Co-investigator
$956,250
Molecular switch function in a prion protein; control of pathways leading to pathogenesis or disease remediation
CIHR · 2019 · Nominated PI
$803,250

All 15 grants and awards

68 publications.

A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation.

Fang A, Tang X, Fleming M, Tancowny B, Wang X, Wang Y, Daude N, Dorosh L, Fleck SC, Rathod V, Coustou V, Cervantes SA, Velásquez CD, Westaway D, Aiken J, McKenzie D, Telling G, Stepanova M, Saupe SJ, Siemer AB, Wille H

Acta neuropathologica2026

DOI: 10.1007/s00401-026-03015-4 PMID: 41995880

Expression of progerin enhances disease-related endpoints in a tau seeding reporter cell system.

Han ZZ, Kang SG, Gomez-Cardona E, Wohlgemuth S, Shmeit K, Arce L, Safar JG, Julien O, Westaway D

GeroScience2026Senior author

DOI: 10.1007/s11357-025-01737-z PMID: 40660080

Microbial Composition, Disease Trajectory and Genetic Background in a Slow Onset Model of Frontotemporal Lobar Degeneration.

Daude N, Machado I, Arce L, Yang J, Westaway D

Biomolecules2025Senior author

DOI: 10.3390/biom15050636 PMID: 40427529

Prion Protein Endoproteolysis: Cleavage Sites, Mechanisms and Connections to Prion Disease.

Castle AR, Westaway D

Journal of neurochemistry2025Senior author

DOI: 10.1111/jnc.16310 PMID: 39874431

Application of N-Terminal Labeling Methods Provide Novel Insights into Endoproteolysis of the Prion Protein in Vivo.

Gomez-Cardona E, Eskandari-Sedighi G, Fahlman R, Westaway D, Julien O

ACS chemical neuroscience2024

DOI: 10.1021/acschemneuro.3c00533 PMID: 38095594

Prion-like strain effects in tauopathies.

Han ZZ, Kang SG, Arce L, Westaway D

Cell and tissue research2023Senior author

DOI: 10.1007/s00441-022-03620-1 PMID: 35460367

Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein.

Castle AR, Kang SG, Eskandari-Sedighi G, Wohlgemuth S, Nguyen MA, Drucker DJ, Mulvihill EE, Westaway D

Proceedings of the National Academy of Sciences of the United States of America2023Senior author

DOI: 10.1073/pnas.2209815120 PMID: 36574660

The effect of Aβ seeding is dependent on the presence of knock-in genes in the App NL-G-F mice.

Lacoursiere SG, Safar J, Westaway D, Mohajerani MH, Sutherland RJ

Frontiers in dementia2022

DOI: 10.3389/frdem.2022.941879 PMID: 39081481

Investigating CRISPR/Cas9 gene drive for production of disease-preventing prion gene alleles.

Castle AR, Wohlgemuth S, Arce L, Westaway D

PloS one2022Senior author

DOI: 10.1371/journal.pone.0269342 PMID: 35671288

Author Correction: Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model.

Soudy R, Kimura R, Patel A, Fu W, Kaur K, Westaway D, Yang J, Jhamandas J

Scientific reports2022

DOI: 10.1038/s41598-022-10922-5 PMID: 35484381

Diverse disease-associated forms of tau; molecular cell biology and relationships to pathogenesis.

Nominated PICIHR2020Project Grant

Principal investigators: Westaway, David

Keywords: Chemical Denaturation; Conformation; Frontotemporal Dementia; Frontotemporal Lobar Degeneration; Ftld-Mapt-P301l; Oligomers; Prions; Protein Strains; Tau; Transgenics

$883,576

Intracerebral seeding with misfolded proteins in second generation AD mouse models: Visualizing spread of pathology.

Co-investigatorCIHR2020Project Grant

Principal investigators: Sutherland, Robert J

Keywords: Alzheimer'S Disease; Amyloid; Calcium Imaging; Dementia; Memory; Mouse Models

$956,250

Molecular switch function in a prion protein; control of pathways leading to pathogenesis or disease remediation

Nominated PICIHR2019Project Grant

Principal investigators: Westaway, David

Keywords: Alzheimer Disease; Nervous System; Neuronal Proteases; Nuclear Magnetic Resonance; Parkinson'S Disease; Prion Disease; Protein Folding; Reversed Genetics; Vitamins

$803,250

Age-dependent development of a primary Tauopathy: the gut/brain axis and biogenesis of Tau strains

Nominated PICIHR2018Operating Grant: Geroscience Demonstration Grants

Principal investigators: Westaway, David

Keywords: Alzheimer'S Disease; Bacterial Transplantation; Frontotemporal Dementia; Gerontology; Gut/Brain Axis; Microbiome; Progeric Mutations; Ribosomal Dna Analysis; Tauopathy; Vagus Nerve

$450,000

Functional consequences of spread of misfolded proteins in the brain

Co-investigatorCIHR2018Planning and Dissemination Grant - Institute Community Support

Principal investigators: Sutherland, Robert J

Keywords: Alzheimer'S Disease; Cognition; Connector; Dementia; Functional Imaging; Memory; Neurodegeneration; Protein Misfiling; Raging; Transgenic

$20,000

Role of lysosomal enzymes cathepsins B and D in neuronal vulnerability: potential implications in Alzheimer's disease pathology

Co-investigatorCIHR2017Project Grant

Principal investigators: Kar, Satyabrata

Keywords: Alzheimer'S Disease; Amyloid Precursor Protein; Animal Models Of Alzheimer'S Disease; Beta-Amyloid Peptide; Endosomal-Lysosomal System; Lysosomal Leakage; Neuroprotection; Neurotoxicity

$742,050

Visualizing stochastic protein misfolding to understand the origins of sporadic Tauopathies

Nominated PICIHR2016Project Grant

Principal investigators: Westaway, David

Keywords: Aging; Neuroanatomy; Neurodegeneration; Preclinical Phase; Prion-Like Diseases; Protein Misfolding; Proteostasis; Sporadic Manifestation; Tau; Transgenics

$244,640

Prion Protein Proteostasis

Nominated PICIHR2014Operating Grant

Principal investigators: Westaway, David

Keywords: Alzheimer'S; Metabolism; Prions; Proteases; Protein Folding; Proteostasis; Transgenics

$710,226

Canada Research Chair Tier 1

Nominated PICIHR2014Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Westaway, David

Keywords: Crc

$1,400,000

H. Chertkow Expression of Interest for CCNA

Principal investigatorCIHR2013Canadian Consortium on Neurodegeneration in Aging - EOI

Principal investigators: Chertkow, Howard M; Andrew, Melissa K; Bartha, Robert; Bellec, Pierre; Belleville, Sylvie N; Bergman, Howard; Black, Sandra E; Borrie, Michael J; Camicioli, J. Richard M; Cashman, Neil R; Collins, Donald L; Cuello, A. Claudio G; Darvesh, Sultan; Dixon, Roger A; Duchesne, Simon; Evans, Alan C; Feldman, Howard; Gauthier, Serge G; Greenwood, Carol E; Herrmann, Nathan; Hogan, David B; Hsiung, Ging-Yuek R; Jacklin, Kristen M; Masellis, Mario; Mihailidis, Alex; Montero Odasso, Manuel M; Morgan, Debra G; Naglie, Gary; Phillips, Natalie A; Poirier, Judes; Rockwood, Kenneth; Rylett, Jane R; Sadavoy, Joel; Smith, Eric E; ST GEORGE-HYSLOP, Peter H; Wellington, Cheryl L; Westaway, David

Keywords: Brain Disease; Cognition; Dementia; Diagnosis; Prevention; Quality Of Life; Therapy; Treatment

$71,606

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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David Westaway

Research

Latest papers

Latest funding

A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Str&#xe4;ussler-Scheinker disease mutation.

Expression of progerin enhances disease-related endpoints in a tau seeding reporter cell system.

Microbial Composition, Disease Trajectory and Genetic Background in a Slow Onset Model of Frontotemporal Lobar Degeneration.

Prion Protein Endoproteolysis: Cleavage Sites, Mechanisms and Connections to Prion Disease.

Application of N-Terminal Labeling Methods Provide Novel Insights into Endoproteolysis of the Prion Protein in Vivo.

Prion-like strain effects in tauopathies.

Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein.

The effect of A&#x3b2; seeding is dependent on the presence of knock-in genes in the App NL-G-F mice.

Investigating CRISPR/Cas9 gene drive for production of disease-preventing prion gene alleles.

Author Correction: Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model.

Frequent collaborators

Holger Wille

Jack Jhamandas

Debbie McKenzie

Olivier Julien

Judd Aiken

Maria Stepanova

Satyabrata Kar

Gerold Schmitt-Ulms

Liang Li

Ian Winship

Richard Fahlman

Sue-Ann Mok

Christopher Power

Jianguo Xia

Vineet Rathod

Howard Young

Fabrizio Giuliani

Ekaterina Rogaeva

Lili-Naz Hazrati

Sabine Gilch

Michael Overduin

A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation.

The effect of Aβ seeding is dependent on the presence of knock-in genes in the App NL-G-F mice.