Mohammed Osman, University of Alberta

Research

Autoimmunity Fibrosis Genomic Mutations Mutations Systemic Sclerosis

Latest papers

Editorial: Prognostic and predictive factors in autoimmune connective tissue disorders, volume II.
Frontiers in immunology · 2026 · senior author
Polysialic acid is associated with immune activation in human peripheral blood nuclear cells.
Glycobiology · 2026
Single-cell analysis reveals immune remodeling of monocytes, NK cells, T cell exhaustion, and Galectin-9-associated depletion of gamma delta and mucosal-associated invariant T cells in Long COVID with ME/CFS.
Frontiers in immunology · 2026

All 50 publications

Latest funding

Decoding Long COVID in women: Immunological mechanisms and clinical implications
CIHR · 2025 · Co-investigator
$1,040,400
Investigating a Novel Cross-DNA Virus as a Pathogenic Trigger of Localized Scleroderma
SSHRC · 2024 · Co-investigator
$125,000
MUC16 (CA125) mutations promote fibrosis and autoimmunity in systemic sclerosis
CIHR · 2023 · Nominated PI
$730,576

All 6 grants and awards

50 publications.

01

Editorial: Prognostic and predictive factors in autoimmune connective tissue disorders, volume II.

Mormile I, Rossi FW, Osman M

Frontiers in immunology2026Senior author

DOI: 10.3389/fimmu.2026.1837711 PMID: 42039212

02

Polysialic acid is associated with immune activation in human peripheral blood nuclear cells.

Makhsous S, Hunter C, Gélinas V, Beauparlant CJ, van Eeden C, Osman M, Droit A, Willis L

Glycobiology2026

DOI: 10.1093/glycob/cwag017 PMID: 41795951

03

Single-cell analysis reveals immune remodeling of monocytes, NK cells, T cell exhaustion, and Galectin-9-associated depletion of gamma delta and mucosal-associated invariant T cells in Long COVID with ME/CFS.

Shahbaz S, Bozorgmehr N, Rahmati A, Abouda A, Syed H, Osman M, Elahi S

Frontiers in immunology2026

DOI: 10.3389/fimmu.2026.1745933 PMID: 41822518

04

Thirsty eyes: a look at dry eyes in autoimmune/inflammatory syndrome induced by adjuvants.

Wowk J, van Eeden C, Redmond D, Osman M, Cohen Tervaert JW

Clinical and experimental rheumatology2026

DOI: 10.55563/clinexprheumatol/h73rbn PMID: 41562351

05

Glucagon-like peptide-1 receptor agonists as metabolic adjuncts in immune-mediated skin disease.

Lazarowitz R, Saroufim L, Sauder M, Osman M, Tardio V, Litvinov IV, Netchiporouk E

Journal of the American Academy of Dermatology2026

DOI: 10.1016/j.jaad.2026.02.047 PMID: 41713583

06

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Goulet D, Guertin C, Larché M, Ferdinand I, Hudson M, Choi MY, Osman M, Pope J, Thorne C, Baron M

Arthritis Care and Research20261 citations

DOI: 10.1002/acr.80098

07

Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients.

Shahbaz S, Rezaeifar M, Syed H, Redmond D, Terveart JWC, Osman M, Elahi S

Brain, behavior, and immunity2025

DOI: 10.1016/j.bbi.2024.11.032 PMID: 39615603

08

Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS.

Shahbaz S, Osman M, Syed H, Mason A, Rosychuk RJ, Cohen Tervaert JW, Elahi S

Cell reports. Medicine2025

DOI: 10.1016/j.xcrm.2025.102449 PMID: 41205594

09

Should Calcium Supplementation be Abandoned in Patients With Calcinosis Cutis?

He R, Osman M, Owczarczyk-Saczonek A, Gniadecki R

Journal of cutaneous medicine and surgery2025

DOI: 10.1177/12034754251320640 PMID: 40072480

10

Transcriptomic skin niches in systemic sclerosis underpin a role for mitochondrial dysfunction.

Wang J, Hennessey D, Iyer A, O'Keefe S, Khan L, Redmond D, Osman M, Gniadecki R

The British journal of dermatology2025

DOI: 10.1093/bjd/ljaf119 PMID: 40172938

Decoding Long COVID in women: Immunological mechanisms and clinical implications

Co-investigatorCIHR2025Project Grant

Principal investigators: Elahi, Shokrollah

Keywords: Long Covid

$1,040,400

Investigating a Novel Cross-DNA Virus as a Pathogenic Trigger of Localized Scleroderma

Co-investigatorSSHRC2024New Frontiers in Research Fund - Exploration

Principal investigators: Netchiporouk, Elena

$125,000

MUC16 (CA125) mutations promote fibrosis and autoimmunity in systemic sclerosis

Nominated PICIHR2023Project Grant

Principal investigators: Osman, Mohammed S; Gniadecki, Robert

Keywords: Autoimmunity; Fibrosis; Genomic Mutations; Mutations; Systemic Sclerosis

$730,576

MUC16 (CA125) mutations promote fibrosis and autoimmunity in systemic sclerosis

Nominated PICIHR2022Pro. Gr. - PA: Inst. of Musculoskeletal Health and Arthritis: IMHA Mandate Areas

Principal investigators: Osman, Mohammed S; Gniadecki, Robert

Keywords: Autoimmunity; Fibrosis; Genomic Mutations; Mutations; Systemic Sclerosis

$100,000

Deciphering immune responses in COVID-19 patients to identify immune correlates of protection and susceptibility for targeted therapeutics

Co-investigatorCIHR2020Operating Grant: COVID-19 - Project Grant

Principal investigators: Elahi, Shokrollah

Keywords: Covid-19; Immune Correlates Of Infection; Sars-Cov-2 Infection; Viral Pathogenesis

$1,071,000

Early Immune System Events Leading to Systemic Sclerosis

Co-investigatorCIHR2018Team Grant: Human Immunology - LOI - Autoimmune diseases related to IMHA pool

Principal investigators: Baron, Murray; Hudson, Marie; Larche, Mark; Wither, Joan E

Keywords: Autologous Hematopoetic Stem Cell Transplant; B Cells; Dendritic Cells; Flow Cytometry; Immunology; Raynaud'S; Systemic Sclerosis; T Cells

$19,999

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Medicine/Nephrology
Mike Petryk School of Dentistry
Dentistry
Dermatology
Rheumatology
Medicine/Endocrinology/Metabolism
Other

Co-authors at University of Alberta, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Shokrollah Elahi

Mike Petryk School of Dentistry

16 shared papers, latest 2026

Murray Baron

Rheumatology

3 shared papers, latest 2026

Nairne Scott-Douglas

Medicine/Nephrology

2 shared papers, latest 2019

Branko Braam

Agricultural, Food and Nutritional Science

2 shared papers, latest 2019

Braden Manns

Medicine/Endocrinology/Metabolism

2 shared papers, latest 2019

Janet Pope

Department of Epidemiology and Biostatistics

2 shared papers, latest 2026

Stephanie Thompson

Medicine/Nephrology

2 shared papers, latest 2019

Elham Rahme

Medicine

1 shared papers, latest 2025

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Autoimmunity Dear Professor Osman, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Editorial: Prognostic and predictive factors in autoimmune connective tissue disorders, volume II." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "MUC16 (CA125) mutations promote fibrosis and autoimmunity in systemic sclerosis" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Mohammed Osman

Research

Latest papers

Latest funding

Editorial: Prognostic and predictive factors in autoimmune connective tissue disorders, volume II.

Polysialic acid is associated with immune activation in human peripheral blood nuclear cells.

Single-cell analysis reveals immune remodeling of monocytes, NK cells, T cell exhaustion, and Galectin-9-associated depletion of gamma delta and mucosal-associated invariant T cells in Long COVID with ME/CFS.

Thirsty eyes: a look at dry eyes in autoimmune/inflammatory syndrome induced by adjuvants.

Glucagon-like peptide-1 receptor agonists as metabolic adjuncts in immune-mediated skin disease.

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients.

Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS.

Should Calcium Supplementation be Abandoned in Patients With Calcinosis Cutis?

Transcriptomic skin niches in systemic sclerosis underpin a role for mitochondrial dysfunction.

Decoding Long COVID in women: Immunological mechanisms and clinical implications

Investigating a Novel Cross-DNA Virus as a Pathogenic Trigger of Localized Scleroderma

MUC16 (CA125) mutations promote fibrosis and autoimmunity in systemic sclerosis

MUC16 (CA125) mutations promote fibrosis and autoimmunity in systemic sclerosis

Deciphering immune responses in COVID-19 patients to identify immune correlates of protection and susceptibility for targeted therapeutics

Early Immune System Events Leading to Systemic Sclerosis

Frequent collaborators

Shokrollah Elahi

Shima Shahbaz

Robert Gniadecki

Elena Netchiporouk

Murray Baron

Nairne Scott-Douglas

Marie Hudson

Branko Braam

Kailash Jindal

Braden Manns

Stephanie Keeling

Brenda Hemmelgarn

Marcello Tonelli

Scott Klarenbach

Margaret Larche

Janet Pope

Nairne Scott-Douglas

Stephanie Thompson

Deborah Assayag

Carter Thorne

Sabrina Hoa

Liang Li

Sasha Bernatsky

Andrew Mason

Elham Rahme