Liang Li, University of Alberta

Research

Chemogenetics High-Calories Diet Hypothalamus Lipidomics Mri Multiomics Bioinformatics Single-Cell Sequencing

Latest papers

The Dry Secretion Metabolome: LC-MS Profiling Distinguishes Subclinical Mastitis from Healthy Udder Quarters Across the Dry Period in Dairy Cows.
Veterinary sciences · 2026
Characterization of multi-stage metabolic alterations in hepatitis B virus-related acute-on-chronic liver failure using high-coverage metabolomics.
Metabolomics : Official journal of the Metabolomic Society · 2026
Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS.
BMC medicine · 2026

All 216 publications

Latest funding

Hypothalamic mechanisms of High-Calorie intervention in ALS
CIHR · 2022 · Nominated PI
$330,000
Development of Mass Spectrometry for Multidimensional Metabolome Analysis
NSERC · 2019 · Principal investigator
$630,000
Development of Mass Spectrometry for Multidimensional Metabolome Analysis
NSERC · 2019 · Principal investigator
$120,000

All 32 grants and awards

From the 150 most recent of 216 publications.

01

The Dry Secretion Metabolome: LC-MS Profiling Distinguishes Subclinical Mastitis from Healthy Udder Quarters Across the Dry Period in Dairy Cows.

Hasanllari B, Kaja M, Zhao S, Luo X, Li L, Ametaj BN

Veterinary sciences2026

DOI: 10.3390/vetsci13040345 PMID: 42076717

02

Characterization of multi-stage metabolic alterations in hepatitis B virus-related acute-on-chronic liver failure using high-coverage metabolomics.

Zhang Z, Jiang H, Zhang G, Chen D, Su X, Li L, Li L

Metabolomics : Official journal of the Metabolomic Society2026

DOI: 10.1007/s11306-026-02462-0 PMID: 42301606

03

Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS.

Krishnamurthy SS, Buzatto AZ, Campkin C, Müller HP, Wiesner D, Weishaupt J, Klose V, Wiesenfarth M, Elmas Z, Herrmann C, Parlak Ö, Günther K, Saad R, Weiland U, Dupuis L, Ludolph A, Li L, Kassubek J, Dorst J, Roselli F

BMC medicine2026

DOI: 10.1186/s12916-026-04749-4 PMID: 41776545

04

Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity.

Marcadet L, Pelaez MC, Desmeules A, Serrano J, Cheng Z, Khademullah CS, Parham E, Kennedy J, Troakes C, Vance C, Soliz J, Durham HD, Li L, Dutchak PA, Sephton CF

Brain : a journal of neurology2026

DOI: 10.1093/brain/awaf328 PMID: 40971894

05

A Comparative Metabolomics Study of Multiple Urological Diseases by Highly Sensitive Dansylation Isotope Labeling LC-MS.

Wang WH, Hsieh YJ, Chen CL, Chang YH, Tsai YH, Chang CH, Li L, Tu WJ, Yu JS, Chen YT

International journal of molecular sciences2025

DOI: 10.3390/ijms262311353 PMID: 41373511

06

Lipidomic Signatures in Microglial Extracellular Vesicles During Acute Inflammation: A Gateway to Neurological Biomarkers.

Ollen-Bittle N, Wang W, Bean KM, Zhao S, Buzatto AZ, Dong Y, Li L, Whitehead SN

Journal of neurochemistry2025

DOI: 10.1111/jnc.70309 PMID: 41292273

07

Placental Morphology and Metabolomic Profile in Uncomplicated Metabolically Healthy Obese Pregnancy.

Sarr O, Rajagopaul A, Zhao S, Wang X, Grynspan D, Eastabrook G, Li L, Regnault TRH, de Vrijer B

Biomedicines2025

DOI: 10.3390/biomedicines13092149 PMID: 41007712

08

Metabolic profiling of amniotic fluid by differential 12C-/13C-isotope dansylation labeling LC-MS for application in trisomy 21 fetuses.

Hsieh YJ, Chang YL, Wu YH, Hung CY, Li L, Yu JS, Chang CH, Tu WJ, Chen YT

Metabolomics : Official journal of the Metabolomic Society2025

DOI: 10.1007/s11306-025-02298-0 PMID: 40789987

09

Study of Metabolite Detectability in Simultaneous Profiling of Amine/Phenol and Hydroxyl Submetabolomes by Analyzing a Mixture of Two Separately Dansyl-Labeled Samples.

Quan S, Zhao S, Li L

Metabolites2025Senior author

DOI: 10.3390/metabo15080496 PMID: 40863114

10

Metabolomic Profiling Identifies Key Metabolites and Defense Pathways in Rlm1-Mediated Blackleg Resistance in Canola.

Zhu X, Gao P, Zhao S, Luo X, Li L, Peng G

International journal of molecular sciences2025

DOI: 10.3390/ijms26125627 PMID: 40565092

Hypothalamic mechanisms of High-Calorie intervention in ALS

Nominated PICIHR2022Operating Grant: Joint Programme on Neurodegenerative Disease Research (JPND)

Principal investigators: Li, Liang

Keywords: Chemogenetics; High-Calories Diet; Hypothalamus; Lipidomics; Mri; Multiomics Bioinformatics; Single-Cell Sequencing

$330,000

Development of Mass Spectrometry for Multidimensional Metabolome Analysis

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Li, Liang

$630,000

Development of Mass Spectrometry for Multidimensional Metabolome Analysis

Principal investigatorNSERC2019DND/NSERC Discovery Grant Supplement

Principal investigators: Li, Liang

$120,000

The scope and functional significance of metabolic enzyme localization in the nucleus

Co-investigatorCIHR2016Project Grant

Principal investigators: Schultz, Michael C

Keywords: Enzyme Activity; Idh1; Intermediary Metabolism; Liquid Chromatography-Mass Spectrometry; Metabolomics; Nuclear Localization; Nucleus; Oncometabolite; Xenopus Oocyte

$500,748

Development of Mass Spectrometric Techniques for Comprehensive Metabolome Analysis in Metabolomics

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Li, Liang

$340,000

High performance centrifuges with rotors

Co-investigatorNSERC2012Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Vederas, John

$117,752

Triple Quadrupole Gas Chromatography - Tandem Mass Spectrometry (GCMS/MS) Instrument with Electron Ionization and Chemical Ionization

Co-investigatorNSERC2012Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Hall, Dennis

$146,651

Discovery of biomarkers of alzheimer's disease using comprehensive and quantitative metabolomics

Principal investigatorNSERC2012Collaborative Health Research Projects

Principal investigators: Li, Liang

$198,500

Analytical Chemistry

Principal investigatorNSERC2011Canada Research Chairs

Principal investigators: Li, Liang

Keywords: CRC

$200,000

Discovery of biomarkers of alzheimer's disease using comprehensive and quantitative metabolomics

Nominated PICIHR2011Collaborative Health Research Projects (NSERC partnered)

Principal investigators: Li, Liang

Keywords: Alzheimer'S Disease; Analytical Chemistry; Disease Biomarkers; Isotope Labeling; Mass Spectrometry; Metabolite Identification; Metabolome Profiling; Metabolomics; Quantitive Analysis

$396,500

Mike Petryk School of Dentistry

1 shared papers, latest 2024

Richard Schulz

Pediatrics/Pharmacology

1 shared papers, latest 2019

Barbra De Vrijer

Department of Obstetrics & Gynaecology

1 shared papers, latest 2025

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Chemogenetics Dear Professor Li, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The Dry Secretion Metabolome: LC-MS Profiling Distinguishes Subclinical Mastitis from Healthy Udder Quarters Across the Dry Period in Dairy Cows." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Hypothalamic mechanisms of High-Calorie intervention in ALS" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]