Rachel Wevrick, University of Alberta

Research

Childhood Obesity Developmental Delay Mental Illness Rare Disease Molecular Genetics Obesity Transgenic Mice

Latest papers

Hypothalamic AAV-BDNF gene therapy improves metabolic function and behavior in the Magel2-null mouse model of Prader-Willi syndrome.
Molecular therapy. Methods & clinical development · 2022
The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism.
The Journal of biological chemistry · 2021 · senior author
The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.
Human genetics · 2020 · senior author

All 37 publications

Latest funding

Biological functions of melanoma antigen (MAGE) proteins
NSERC · 2020 · Principal investigator
$64,000
9th International Prader Willi Syndrome Organisation Conference: 2016 Scientific Conference
CIHR · 2016 · Nominated PI
$8,500
Exploration of a melanoma antigen (MAGE)-E3 ubiquitin ligase circuit governing circadian rhythm
NSERC · 2014 · Principal investigator
$175,000

All 9 grants and awards

37 publications.

01

Hypothalamic AAV-BDNF gene therapy improves metabolic function and behavior in the Magel2-null mouse model of Prader-Willi syndrome.

Queen NJ, Zou X, Anderson JM, Huang W, Appana B, Komatineni S, Wevrick R, Cao L

Molecular therapy. Methods & clinical development2022

DOI: 10.1016/j.omtm.2022.09.012 PMID: 36284766

02

The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism.

Sanderson MR, Fahlman RP, Wevrick R

The Journal of biological chemistry2021Senior author

DOI: 10.1016/j.jbc.2021.100959 PMID: 34265304

03

The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.

Sanderson MR, Badior KE, Fahlman RP, Wevrick R

Human genetics2020Senior author

DOI: 10.1007/s00439-020-02193-9 PMID: 32529326

04

Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits.

Kelly E, Meng F, Fujita H, Morgado F, Kazemi Y, Rice LC, Ren C, Escamilla CO, Gibson JM, Sajadi S, Pendry RJ, Tan T, Ellegood J, Basson MA, Blakely RD, Dindot SV, Golzio C, Hahn MK, Katsanis N, Robins DM, Silverman JL, Singh KK, Wevrick R, Taylor MJ, Hammill C, Anagnostou E, Pfeiffer BE, Stoodley CJ, Lerch JP, du Lac S, Tsai PT

Nature neuroscience2020

DOI: 10.1038/s41593-020-0665-z PMID: 32661395

05

Disentangling ingestive behavior-related phenotypes in Prader-Willi syndrome: Integrating information from nonclinical studies and clinical trials to better understand the pathophysiology of hyperphagia and obesity.

Wevrick R

Physiology & behavior2020First author

DOI: 10.1016/j.physbeh.2020.112864 PMID: 32156555

06

A MAGEL2-deubiquitinase complex modulates the ubiquitination of circadian rhythm protein CRY1.

Carias KV, Zoeteman M, Seewald A, Sanderson MR, Bischof JM, Wevrick R

PloS one2020Senior author

DOI: 10.1371/journal.pone.0230874 PMID: 32315313

07

Preclinical Testing in Translational Animal Models of Prader-Willi Syndrome: Overview and Gap Analysis.

Carias KV, Wevrick R

Molecular therapy. Methods & clinical development2019Senior author

DOI: 10.1016/j.omtm.2019.03.001 PMID: 30989085

08

Clinical and genetic analysis of children with a dual diagnosis of Tourette syndrome and autism spectrum disorder.

Carias KV, Wevrick R

Journal of psychiatric research2019Senior author

DOI: 10.1016/j.jpsychires.2019.01.023 PMID: 30771620

09

ROHHAD and Prader-Willi syndrome (PWS): clinical and genetic comparison.

Barclay SF, Rand CM, Nguyen L, Wilson RJA, Wevrick R, Gibson WT, Bech-Hansen NT, Weese-Mayer DE

Orphanet journal of rare diseases2018

DOI: 10.1186/s13023-018-0860-0 PMID: 30029683

10

Genetic analysis of very obese children with autism spectrum disorder.

Cortes HD, Wevrick R

Molecular genetics and genomics : MGG2018Senior author

DOI: 10.1007/s00438-018-1418-5 PMID: 29327328

Biological functions of melanoma antigen (MAGE) proteins

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Wevrick, Rachel

$64,000

9th International Prader Willi Syndrome Organisation Conference: 2016 Scientific Conference

Nominated PICIHR2016Planning and Dissemination Grant - Institute Community Support

Principal investigators: Wevrick, Rachel; Barron, Carole

Keywords: Childhood Obesity; Developmental Delay; Mental Illness; Rare Disease

$8,500

Exploration of a melanoma antigen (MAGE)-E3 ubiquitin ligase circuit governing circadian rhythm

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Wevrick, Rachel

$175,000

Genetic and functional analysis of a mouse model of pediatric obesity

Nominated PICIHR2013Operating Grant

Principal investigators: Wevrick, Rachel

Keywords: Molecular Genetics; Obesity; Transgenic Mice

$789,888

Investigation of leptin resistance in mouse models of childhood-onset morbid obesity.

SupervisorCIHR2010Master's Award: Canada Graduate Scholarships

Principal investigators: Devos, Julia J

Keywords: Hypothalamus; Leptin; Leptin Resistance; Magel2; Mouse Models; Neurons; Obesity; Prader-Willi Syndrome

$17,500

Appetite and Metabolism in Magel2-null Mice: A Model for Prader Willi Syndrome

SupervisorCIHR2009Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Mercer, Rebecca E

Keywords: Diet; Electrophysiology; Genetics; Hypothalamus; Immunohistochemistry; Metabolism; Obesity; Pharmacology; Prader-Willi Syndrome; Rt-Pcr

$70,000

Function of magel2 in circadian rhythm

Principal investigatorNSERC2008Discovery Grants Program - Individual

Principal investigators: Wevrick, Rachel

$150,000

Canadian Genetic Diseases Network (CGDN) / Réseau Canadien de maladies génétiques

Co-investigatorNSERC2005Research Management Funds - Group

Principal investigators: Hayden, Michael

$250,000

Function of magel2 in the hypothalamus

Principal investigatorNSERC2005Discovery Grants Program - Individual

Principal investigators: Wevrick, Rachel

$73,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medical Genetics
Physiology
Psychology
Biological Sciences

Co-authors at University of Alberta, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Silvia Pagliardini

Physiology

2 shared papers, latest 2008

Kirst King-Jones

Biological Sciences

1 shared papers, latest 2013

Evdokia Anagnostou

Psychology

1 shared papers, latest 2020

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2020

Subject: Prospective PhD student: Childhood Obesity Dear Professor Wevrick, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Hypothalamic AAV-BDNF gene therapy improves metabolic function and behavior in the Magel2-null mouse model of Prader-Willi syndrome." (2022), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Biological functions of melanoma antigen (MAGE) proteins" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]