Faculty profile

Silvia Pagliardini

ResearcherPhysiologyUniversity of Alberta

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Alberta directory, so their courses may be missing. Find their university profile.

Silvia Pagliardini

Researcher

Physiology

Health Sciences

University of Alberta

Edmonton, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
14 publications in the last five years, latest in 2026.
Senior (last) author on 9 recent papers, a sign of leading a research group.
Principal investigator on 9 research grants (6 CIHR, 3 NSERC), most recently in 2026.
Supervised 2 trainees who won CIHR awards, most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Sleep Disordered Breathing Chemogenetics Sleep Expiration Optogenetics Abdominal Muscles Active Expiration Emg And Eeg Activity

Latest papers

When CO2 sensing fails: Protective effects of sex hormones and potential mechanisms.
Journal of neuroendocrinology · 2026 · senior author
Improved sleep spindle detection in rats using the BOSC method: A comparison with the traditional automated approach.
Journal of neuroscience methods · 2026
CRISPR/Cas9-mediated PHOX2B functional knock-out in IMR32 neuroblastoma cells impairs neuronal excitability through dysregulation of ion channels genes.
Frontiers in physiology · 2026

All 39 publications

Latest funding

The "Ins" and "Outs" of ventilation during sleep: empowering active expiration to counteract loss of inspiratory activity in sleep disordered breathing
CIHR · 2026 · Nominated PI
$1,105,426
Cellular and system investigation of the role of sex hormones and PHOX2B on respiratory control
CIHR · 2022 · Nominated PI
$719,100
Sex hormones and their use in hypoventilation syndromes: site of action and mechanism
CIHR · 2022 · Supervisor
$40,000

All 12 grants and awards

39 publications.

When CO2 sensing fails: Protective effects of sex hormones and potential mechanisms.

Janes TA, Cardani S, Pagliardini S

Journal of neuroendocrinology2026Senior author

DOI: 10.1111/jne.70256 PMID: 42708468

Improved sleep spindle detection in rats using the BOSC method: A comparison with the traditional automated approach.

Turnbull C, Prostebby M, Babale I, Pagliardini S, Dickson C

Journal of neuroscience methods2026

DOI: 10.1016/j.jneumeth.2026.110812 PMID: 42203162

CRISPR/Cas9-mediated PHOX2B functional knock-out in IMR32 neuroblastoma cells impairs neuronal excitability through dysregulation of ion channels genes.

Cardani S, Bertocchi M, Donà E, Chiesa F, Cambria C, Cuadros Gamboa AL, Piscitelli E, Rancic V, Gosgnach S, Pagliardini S, Antonucci F, Fornasari D, Di Lascio S, Benfante R

Frontiers in physiology2026

DOI: 10.3389/fphys.2026.1844142 PMID: 42422362

Sex Differences in the Effects of Etonogestrel on Respiratory Recovery in an In Vivo Rat Model of Central Chemoreflex Impairment.

Cardani S, Janes TA, Asif R, Pagliardini S

Acta physiologica (Oxford, England)2026Senior author

DOI: 10.1111/apha.70194 PMID: 41823358

Activation of the periaqueductal gray controls respiratory output through a distributed brain network.

Prostebby M, Saini J, Biancardi V, Dickson CT, Pagliardini S

Frontiers in physiology2025Senior author

DOI: 10.3389/fphys.2025.1516771 PMID: 39911274

Mapping responses to focal injections of bicuculline in the lateral parafacial region identifies core regions for maximal generation of active expiration.

Pisanski A, Prostebby M, Dickson CT, Pagliardini S

eLife2024Senior author

DOI: 10.7554/elife.94276 PMID: 39017665

Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the central CO2 chemoreflex in rats.

Cardani S, Janes TA, Betzner W, Pagliardini S

eLife2024Senior author

DOI: 10.7554/elife.94653 PMID: 38727716

Etonogestrel promotes respiratory recovery in an in vivo rat model of central chemoreflex impairment.

Janes TA, Cardani S, Saini JK, Pagliardini S

Acta physiologica (Oxford, England)2024Senior author

DOI: 10.1111/apha.14093 PMID: 38258900

Urethane provides an unparalleled anaesthetic model for natural sleep: Commentary on Mondino et al., 2022.

Ward-Flanagan R, Pagliardini S, Dickson CT

The European journal of neuroscience2024

DOI: 10.1111/ejn.15985 PMID: 37041120

Cholinergic projections to the preBötzinger complex.

Biancardi V, Yang X, Ding X, Passi D, Funk GD, Pagliardini S

The Journal of comparative neurology2023Senior author

DOI: 10.1002/cne.25497 PMID: 37211631

The "Ins" and "Outs" of ventilation during sleep: empowering active expiration to counteract loss of inspiratory activity in sleep disordered breathing

Nominated PICIHR2026Project Grant

Principal investigators: Pagliardini, Silvia

Keywords: Abdominal Muscles; Active Expiration; Chemogenetics; Emg And Eeg Activity; Hypoxia; Optogenetics; Rats; Sleep Disordered Breathing; Transgenic Mice; Ventilatory Control

$1,105,426

Cellular and system investigation of the role of sex hormones and PHOX2B on respiratory control

Nominated PICIHR2022Project Grant

Principal investigators: Pagliardini, Silvia

Keywords: Central Hypoventilation; Chemosensitivity; Congenital Central Hypoventilation Syndrome; Gene And Protein Expression; Hypercapnia And Hypoxia; Phox2b; Progesterone Receptors; Sex Hormones; Viral Constructs And Shrna; Whole-Body Plethysmography

$719,100

Sex hormones and their use in hypoventilation syndromes: site of action and mechanism

SupervisorCIHR2022Canadian Lung Association Research Fellowship

Principal investigators: Cardani, Silvia

Keywords: Co2 Sensing; Cogenital Central Hypoventilation Syndrome; Neurons; Phox2b; Sex Hormones

$40,000

Remembering how to breathe - can progesterone rescue breathing in rat models of hypoventilation?

SupervisorCIHR2021CIHR Fellowship

Principal investigators: Janes, Tara

Keywords: Brainstem; Co2 Sensing; Congenital Central Hypoventilation Syndrome; Control Of Breathing; Progesterone

$135,000

Exploring the connectome of the respiratory network

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Pagliardini, Silvia

$132,000

Systematic preclinical evaluation of cannabinoid influences on sleep and breathing

Nominated PICIHR2019Team Grant: Cannabis Research in Priority Areas

Principal investigators: Pagliardini, Silvia

Keywords: Cannabinoids; Eeg Activity; Emg Recordings; Extracellular Recordings; In Vivo And In Vitro Electrophysiology; Pharmacology; Respiratory Activity; Sleep; Telemetry; Unit Recordings

$1,150,000

Unravelling the contribution to the hypoxic ventilatory response of purinergic and glial signalling in the preBötzinger Complex

Co-investigatorCIHR2018Project Grant

Principal investigators: Funk, Gregory D

Keywords: Adenosine; Apnea Of Prematurity; Atp; Control Of Breathing; Development; Electrophysiology; Glia; Hypoxia; In Vitro And In Vivo; Rodent

$852,976

The "Ins" and "Outs" of ventilation during sleep: Brainstem coordination of active inspiration AND expiration

Nominated PICIHR2017Project Grant

Principal investigators: Pagliardini, Silvia

Keywords: Chemogenetics; Emg Eeg Recordings; Expiration; Optogenetics; Rem Sleep; Respiratory Control; Sleep Disordered Breathing

$734,400

Control of expiration in the newborn period

Nominated PICIHR2016Catalyst Grant: Catalyzing Innovation in Preterm Birth Research

Principal investigators: Pagliardini, Silvia

Keywords: Abdominal Activity; Chemogenetics; Expiration; Human Infants; Rat Models; Sleep; Sleep Disordered Breathing

$199,852

Ventilation during sleep: the functional role of expiratory activity in infants and rodents

Nominated PICIHR2014Operating Grant - PA: ICRH - New investigators (Bridge Funding)

Principal investigators: Pagliardini, Silvia

Keywords: Brainstem Physiology; Emg And Eeg Recording; Expiration; Infants; Parafacial Respiratory Group; Rodents; Sleep; Sleep Disordered Breathing; Ventilation

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Silvia Pagliardini

Research

Latest papers

Latest funding

When CO2 sensing fails: Protective effects of sex hormones and potential mechanisms.

Improved sleep spindle detection in rats using the BOSC method: A comparison with the traditional automated approach.

CRISPR/Cas9-mediated PHOX2B functional knock-out in IMR32 neuroblastoma cells impairs neuronal excitability through dysregulation of ion channels genes.

Sex Differences in the Effects of Etonogestrel on Respiratory Recovery in an In Vivo Rat Model of Central Chemoreflex Impairment.

Activation of the periaqueductal gray controls respiratory output through a distributed brain network.

Mapping responses to focal injections of bicuculline in the lateral parafacial region identifies core regions for maximal generation of active expiration.

Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the central CO2 chemoreflex in rats.

Etonogestrel promotes respiratory recovery in an in vivo rat model of central chemoreflex impairment.

Urethane provides an unparalleled anaesthetic model for natural sleep: Commentary on Mondino et al., 2022.

Cholinergic projections to the preBötzinger complex.

The "Ins" and "Outs" of ventilation during sleep: empowering active expiration to counteract loss of inspiratory activity in sleep disordered breathing

Cellular and system investigation of the role of sex hormones and PHOX2B on respiratory control

Sex hormones and their use in hypoventilation syndromes: site of action and mechanism

Remembering how to breathe - can progesterone rescue breathing in rat models of hypoventilation?

Exploring the connectome of the respiratory network

Systematic preclinical evaluation of cannabinoid influences on sleep and breathing

Unravelling the contribution to the hypoxic ventilatory response of purinergic and glial signalling in the preBötzinger Complex

The "Ins" and "Outs" of ventilation during sleep: Brainstem coordination of active inspiration AND expiration

Control of expiration in the newborn period

Ventilation during sleep: the functional role of expiratory activity in infants and rodents

Frequent collaborators

Simon Gosgnach

Rachel Wevrick

Daniel Graf

Carlos Flores-Mir

Vincent Joseph

Frederick Colbourne

Silvia Pagliardini

Research

Latest papers

Latest funding

When CO2 sensing fails: Protective effects of sex hormones and potential mechanisms.

Improved sleep spindle detection in rats using the BOSC method: A comparison with the traditional automated approach.

CRISPR/Cas9-mediated PHOX2B functional knock-out in IMR32 neuroblastoma cells impairs neuronal excitability through dysregulation of ion channels genes.

Sex Differences in the Effects of Etonogestrel on Respiratory Recovery in an In&#xa0;Vivo Rat Model of Central Chemoreflex Impairment.

Activation of the periaqueductal gray controls respiratory output through a distributed brain network.

Mapping responses to focal injections of bicuculline in the lateral parafacial region identifies core regions for maximal generation of active expiration.

Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the central CO2 chemoreflex in rats.

Etonogestrel promotes respiratory recovery in an in&#xa0;vivo rat model of central chemoreflex impairment.

Urethane provides an unparalleled anaesthetic model for natural sleep: Commentary on Mondino et al., 2022.

Cholinergic projections to the preB&#xf6;tzinger complex.

Exploring the connectome of the respiratory network

Frequent collaborators

Simon Gosgnach

Rachel Wevrick

Daniel Graf

Carlos Flores-Mir

Vincent Joseph

Frederick Colbourne

Sex Differences in the Effects of Etonogestrel on Respiratory Recovery in an In Vivo Rat Model of Central Chemoreflex Impairment.

Etonogestrel promotes respiratory recovery in an in vivo rat model of central chemoreflex impairment.

Cholinergic projections to the preBötzinger complex.