Vanessa Meier-Stephenson

Research

Vaccine Adjuvanted Vaccine Hepatitis C Virus Peptide-Based Vaccine Group A Streptococcus

Latest papers

Cytosolic DNA structures produced by mismatch repair deficiency coordinate anti-tumor immunity in colorectal cancer.
Cell reports · 2026
Barriers to Hepatitis B Treatment: A Multicentre Cross‐Sectional Registry and Survey Study by the Canadian Hepatitis B Network
Liver · 2026
Comparative structural insights of X protein across species and the "lost" BH3-like domain that may explain the absence of hepatocellular carcinoma in birds.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2025 · senior author

All 22 publications

Latest funding

Phase 1 randomized, double-blinded, placebo-controlled clinical trial of an adjuvanted protein-based Hepatitis C Virus (HCV) vaccine candidate
CIHR · 2023 · Nominated PI
$2,050,829
Waking up Hepatitis B virus (HBV)'s chronic form to maximize attack by promoter-targeting therapies
CIHR · 2023 · Supervisor
$6,000
Phase 1 randomized, double-blinded, placebo-controlled clinical trial of an adjuvanted protein-based Hepatitis C Virus (HCV) vaccine candidate
CIHR · 2023 · Nominated PI
$512,707

All 5 grants and awards

22 publications.

01

Cytosolic DNA structures produced by mismatch repair deficiency coordinate anti-tumor immunity in colorectal cancer.

Mosley SR, Lapa N, Namdar A, Catley TE, Meier-Stephenson F, Mowat C, Gao P, Sun X, Meier-Stephenson V, Pyne ALB, Baker K

Cell reports2026

DOI: 10.1016/j.celrep.2026.117012 PMID: 41722050

02

Barriers to Hepatitis B Treatment: A Multicentre Cross‐Sectional Registry and Survey Study by the Canadian Hepatitis B Network

Ko HH, Vienneau J, Cooper CL, Crotty P, Congly SE, Brahmania M, Ramji A, Kelly E, Crawley AM, Doucette K

Liver2026

DOI: 10.1111/liv.70835

03

Comparative structural insights of X protein across species and the "lost" BH3-like domain that may explain the absence of hepatocellular carcinoma in birds.

Kaur K, Beghin J, Meier-Stephenson V

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2025Senior author

DOI: 10.1016/j.meegid.2025.105777 PMID: 40472953

04

Cytosolic DNA composition is determined by genomic instability mechanism and regulates dendritic cell-mediated anti-tumor immunity.

Mosley SR, Chen A, Doell DNW, Choi S, Mowat C, Meier-Stephenson F, Meier-Stephenson V, Baker K

Cell reports2025

DOI: 10.1016/j.celrep.2024.115177 PMID: 39864057

05

Viral Appropriation of Specificity Protein 1 (Sp1): The Role of Sp1 in Human Retro- and DNA Viruses in Promoter Activation and Beyond.

Sviderskaia K, Meier-Stephenson V

Viruses2025Senior author

DOI: 10.3390/v17030295 PMID: 40143226

06

A phase 1 randomized controlled trial of a peptide-based group A streptococcal vaccine in healthy volunteers.

Meier-Stephenson V, Hawkes MT, Burton C, Calcutt A, Davis C, Dooley J, Good M, Houghton M, Keeffe E, Kim K, Lepletier A, O'Neil C, Ogbuehi I, Ozberk V, Pandey M, Reynolds S, Seth A, Stokes W, Tse-Chang A, Tyrrell B, Tyrrell DL, Tyrrell GJ, Yaskina M

Trials2024First author

DOI: 10.1186/s13063-024-08634-4 PMID: 39563457

07

Development of a single-domain antibody to target a G-quadruplex located on the hepatitis B virus covalently closed circular DNA genome.

Figueroa GB, D'souza S, Pereira HS, Vasudeva G, Figueroa SB, Robinson ZE, Badmalia MD, Meier-Stephenson V, Corcoran JA, van Marle G, Ni Y, Urban S, Coffin CS, Patel TR

Journal of medical virology2024

DOI: 10.1002/jmv.29692 PMID: 38804172

08

Hepatitis B virus reactivation in hepatitis B core antibody positive lung transplant recipients.

Fernandez-Garcia OA, Zelyas N, Meier-Stephenson V, Halloran K, Doucette K

JHLT open2024

DOI: 10.1016/j.jhlto.2023.100018 PMID: 40145108

09

The domestication of SARS-CoV-2 into a seasonal infection by viral variants.

McClelland RD, Lin YJ, Culp TN, Noyce R, Evans D, Hobman TC, Meier-Stephenson V, Marchant DJ

Frontiers in microbiology2023

DOI: 10.3389/fmicb.2023.1289387 PMID: 38188566

10

Does hepatitis delta virus have a preference for hepatitis B virus genotype? A systematic review of the literature.

Beghin J, Meier-Stephenson V

Journal of viral hepatitis2023Senior author

DOI: 10.1111/jvh.13889 PMID: 37786351

Phase 1 randomized, double-blinded, placebo-controlled clinical trial of an adjuvanted protein-based Hepatitis C Virus (HCV) vaccine candidate

Nominated PICIHR2023Operating Grant: Clinical Trials Projects

Principal investigators: Meier-Stephenson, Vanessa; Cooper, Curtis L; Feld, Jordan J; Houghton, Michael; Richer, Lawrence P

Keywords: Adjuvanted Vaccine; Hepatitis C Virus; Peptide-Based Vaccine; Vaccine

$2,050,829

Waking up Hepatitis B virus (HBV)'s chronic form to maximize attack by promoter-targeting therapies

SupervisorCIHR2023Undergraduate Student Research Awards (USRA)

Principal investigators: Kasinyabo, Emmanuelle

Keywords: Cell; Chronic; Dna; Drugs; Epigenetic; Hepatitis B; Hepatocytes; Protein; Therapies

$6,000

Phase 1 randomized, double-blinded, placebo-controlled clinical trial of an adjuvanted protein-based Hepatitis C Virus (HCV) vaccine candidate

Nominated PICIHR2023Operating Grant: Clinical Trials Projects - Indirect Costs

Principal investigators: Meier-Stephenson, Vanessa; Cooper, Curtis L; Feld, Jordan J; Houghton, Michael; Richer, Lawrence P

Keywords: Adjuvanted Vaccine; Hepatitis C Virus; Peptide-Based Vaccine; Vaccine

$512,707

A Phase 1 Clinical Trial of a Peptide-Based Group A Streptococcal Vaccine

Principal investigatorCIHR2022Operating Grant: Clinical Trials Projects - Indirect Costs

Principal investigators: Hawkes, Michael T; Meier-Stephenson, Vanessa; Pandey, Manisha; Tyrrell, D. Lorne J; Tyrrell, Gregory J

Keywords: Group A Streptococcus; Vaccine

$134,166

A Phase 1 Clinical Trial of a Peptide-Based Group A Streptococcal Vaccine

Principal investigatorCIHR2022Operating Grant: Clinical Trials Projects

Principal investigators: Hawkes, Michael T; Meier-Stephenson, Vanessa; Pandey, Manisha; Tyrrell, D. Lorne J; Tyrrell, Gregory J

Keywords: Group A Streptococcus; Vaccine

$536,665

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Medical Microbiology and Immunology
Pediatrics
Biochemistry and Molecular Biology
Oncology
Department of Medicine
School of Nursing
Other

1 shared papers, latest 2023

Maya Shmulevitz

Medical Microbiology and Immunology

1 shared papers, latest 2023

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A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Vaccine Dear Professor Meier-Stephenson, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Cytosolic DNA structures produced by mismatch repair deficiency coordinate anti-tumor immunity in colorectal cancer." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Phase 1 randomized, double-blinded, placebo-controlled clinical trial of an adjuvanted protein-based Hepatitis C Virus (HCV) vaccine candidate" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]