Frank Jirik

Radioactive Air Pollutant Induced Disease (RAPID) Prevention - Understanding and preventing health risks from particle radiation-emitting radioisotope inhalation, as modified by genetic ancestry and mixed exposure with combustion particulates.

Principal investigators: Goodarzi, Aaron; Mekarski, Pawel; Aristizabal, Maria J; Brenner, Darren M; Ezeife, Doreen; Jirik, Frank R; Wallace, Alison M

Keywords: 1.Radon Gas; 10.Early Detection; 2.Combustion Particulates; 3.Lung Cancer Risk; 4.Genetic Ancestry; 5.Low Dose Radiation; 6.Dna Repair Capacity; 7.Risk Communication; 8.Primary Prevention; 9.Exposome

Phenotypic analysis of a putative mouse model for 'STING-associated vasculopathy with onset in infancy' (SAVI): an autosomal dominant auto-inflammatory interferonopathy

Principal investigators: Jirik, Frank R

Keywords: Acral Vasculopathy And Necrosis; Autosomal Dominant Interferonopathy; Conditional Gene Activation Via Cre-Loxp Technology; Intravital And X-Ray Microscopy; Mouse Model Of Human Savi; Stimulator Of Interferon Genes (Sting); Sting-Associated Vasculopathy Of Infancy (Savi); Thermoregulatory Mechanisms; Transgenic And Knockout Mice; Type I Interferons

Harnessing STING activation for the treatment of sarcoma

Principal investigators: Monument, Michael J

Keywords: Cancer; Gene Therapy; Immunotherapy; Mouse Models; Sarcoma; Stimulator Of Interferon Genes (Sting); Tumour Microenvironment

Stimulator of interferon genes (STING)-induced tumour-associated macrophage re-education as a novel strategy for the treatment of lung cancer.

Principal investigators: Jirik, Frank R

Keywords: Cyclic Dinucleotides; Image Guided Radiation Therapy (Igrt); Imaging Technologies; Immunotherapy/Checkpoint Inhibition; Non-Small Cell Lung Cancer (Nsclc); Oncolytic Viruses; Stimulator Of Interferon Genes (Sting); Syngeneic Models Of Lung Cancer; Transgenic Mice; Tumour-Associated Macrophages

Intravascular Immunity In Chronic Inflammatory Lung Diseases

Principal investigators: Kubes, Paul

Keywords: Cancer; Imaging; Infection; Inflammation; Inkt Cells; Lung Disease; Metastasis; Monocytes; Neutrophils; Sterile Injury

Stem Cell Network/Réseau de cellules souches

Principal investigators: Rudnicki, Michael

Identifying factors responsible for enhancing the metastatic potential of xenografted NSCLC cells.

Principal investigators: Jirik, Frank R

Keywords: Bioluminescence; Cancer; Expression Microarray; Metastasis; Mice; Microrna; Non-Small Cell Lung Cancer; Oncogene; Tumor Suppressor; Xenograft

Developing a zinc finger nuclease-mediated method of targeted-transgenesis for the conditional over-expression of microRNAs in mice.

Principal investigators: Jirik, Frank R

Keywords: Arthritis; Conditional Mutation (Cre-Loxp); Epigenetics; Homologous Recombination; Micro-Rna; Transgenic Mice; Zinc Finger Nuclease

Characterization of a novel model of inflammation-induced gastric neoplasia.

Principal investigators: Jirik, Frank R

Keywords: Cancer; Gastric Neoplasia; Immunology; Interleukins; T Lymphocytes; Transgenic Mice

Investigating the role of mismatch repair and genomic instability in a mouse model of lung cancer

Principal investigators: Downey, Charlene M

Keywords: Bioluminescence Imaging; Cancer; Dna Repair; Gender Differences; Generation Of Cell Lines; Genomic Instability; Lung; Micro-Computed Tomography Imaging; Mouse Model; Pathology