Karl Riabowol, University of Calgary

Research

Aging Senescence P53 Acetylation Epigenome Ing5 Knockout Lifespan

Latest papers

OverlappING and DivergING roles of ING4 and ING5 in cancer, differentiation and development.
Frontiers in cell and developmental biology · 2026 · senior author
Protocol for enhancing CRISPR-Cas9 genome editing using histone deacetylase inhibition and engineered virus-like particle delivery.
STAR protocols · 2026 · senior author
Lgmn targets two distinct GPCRs, PAR2 and µ-OR1, and induces cell death in acute lymphoblastic leukemia through an intracellular Ca²⁺ imbalance triggered by ER Ca²⁺ release.
Cell death discovery · 2026

All 60 publications

Latest funding

Stem Cell Function in Biological Aging
CIHR · 2023 · Nominated PI
$50,000
Stem Cell Function in Biological Aging
CIHR · 2023 · Nominated PI
$1,227,826
Oxygen-Regulated Tissue Culturing for Accurate In Virto Cell Analyses
NSERC · 2022 · Principal investigator
$150,000

All 11 grants and awards

60 publications.

01

OverlappING and DivergING roles of ING4 and ING5 in cancer, differentiation and development.

Dadoyan S, Bartizal TJ, Amarsingha S, Riabowol K

Frontiers in cell and developmental biology2026Senior author

DOI: 10.3389/fcell.2026.1850852 PMID: 42577687

02

Protocol for enhancing CRISPR-Cas9 genome editing using histone deacetylase inhibition and engineered virus-like particle delivery.

Djamshidi M, Tanida R, Heshmatzad K, Krowicki H, Hill A, Yang Y, Riabowol K

STAR protocols2026Senior author

DOI: 10.1016/j.xpro.2026.104493 PMID: 42012982

03

Lgmn targets two distinct GPCRs, PAR2 and µ-OR1, and induces cell death in acute lymphoblastic leukemia through an intracellular Ca²⁺ imbalance triggered by ER Ca²⁺ release.

Lee JK, Riabowol K, Lee KY

Cell death discovery2026

DOI: 10.1038/s41420-026-03003-3 PMID: 41792098

04

A recently evolved domain of the human ING1 epigenetic regulator targets mitochondria and induces senescence.

Bertschmann J, Liu G, Djamshidi M, Heshmatazad K, Romanov Y, Dhaliwahl J, Hojjat H, Yang Y, de Koning APJ, Riabowol K, Hill A

Cellular and molecular life sciences : CMLS2026

DOI: 10.1007/s00018-025-06076-y PMID: 41617915

05

FAME-CRISPR improves CRISPR-Cas9 genome editing via HDAC inhibition and engineered virus-like particle delivery.

Djamshidi M, Hill A, Heshmatzad K, Langley J, Krowicki H, Ali M, Yang Y, Tanida R, Abdul-Careem MF, Billon P, Riabowol K

Cell reports methods2026Senior author

DOI: 10.1016/j.crmeth.2025.101248 PMID: 41344324

06

Functions of TIP60/NuA4 Complex Subunits in Cell Differentiation.

Hashemi F, Nourozi A, Loushab MS, Riabowol K

Cells2025Senior author

DOI: 10.3390/cells14211720 PMID: 41227365

07

hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan.

Adam N, Yang Y, Djamshidi M, Seifan S, Ting NSY, Glover J, Touret N, Gordon PMK, Vineetha Warriyar KV, Krowicki H, Garcia CK, Savage SA, Goodarzi AA, Baird DM, Beattie TL, Riabowol K

Aging cell2025Senior author

DOI: 10.1111/acel.70105 PMID: 40371663

08

Tissue-specific localization of the ING4 targeting subunit of the HBO1 histone acetyltransferase in the cytoplasm and nucleus of secretory cells.

Dantas A, Shueili BA, Park J, Abdullah S, Bertschmann J, Krowicki H, Djamshidi M, Yang Y, Blote K, Thalappilly S, Riabowol K

Histochemistry and cell biology2025Senior author

DOI: 10.1007/s00418-025-02385-2 PMID: 40402282

09

L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand.

Lee JK, Riabowol K, Wang X, Lee KY

Cell death discovery2025

DOI: 10.1038/s41420-025-02467-z PMID: 40195325

10

Loss of ING3 in the Prostate Leads to Activation of DNA Damage Repair Markers.

Lang V, Barones L, Hu SM, Hashemi F, Blote K, Riabowol K, Fink D

Cancers2025

DOI: 10.3390/cancers17061037 PMID: 40149370

Stem Cell Function in Biological Aging

Nominated PICIHR2023PRIZE - Pro. Gr. - PA: Award of Excellence in Research in Aging

Principal investigators: Riabowol, Karl T

Keywords: Biomedical

$50,000

Stem Cell Function in Biological Aging

Nominated PICIHR2023Project Grant

Principal investigators: Riabowol, Karl T

Keywords: Acetylation; Aging; Epigenome; Ing5; Knockout; Lifespan; Neural Stem Cells; P53; Senescence; Transgenic Mice

$1,227,826

Oxygen-Regulated Tissue Culturing for Accurate In Virto Cell Analyses

Principal investigatorNSERC2022Research Tools and Instruments

Principal investigators: Riabowol, Karl

$150,000

Stem Cell Function in Biological Aging

Nominated PICIHR2022Project Grant

Principal investigators: Riabowol, Karl T

Keywords: Acetylation; Aging; Apoptosis; Dna Damage; Epigenome; Ing5; Knockout; Lifespan; Senescence; Stem Cells

$100,000

ING1a mechanisms of cell senescence

Nominated PICIHR2021Project Grant

Principal investigators: Riabowol, Karl T

Keywords: Chromatin; Epigenetics; Hdac; Immunofluorescence; Ing1a; Interactome; Isoform; Mitochondria; Oxidative Damage; Senescence

$898,876

Evaluation of COVID-19 antibodies, cell-mediated immunity and telomeres following COVID-19 immunization or natural infection in an immune compromised population: An HIV Cohort Study

Principal investigatorCIHR2021Operating Grant: Emerging COVID-19 Research Gaps and Priorities - Vaccines

Principal investigators: Gill, Michael J; Hu, Jia; McMillan, Jacqueline M; Power, Christopher; Riabowol, Karl T

Keywords: Cell Mediated Immunity; Covid-19; Covid-19 Antibody Response; Covid-19 Vaccine; Immune Compromised; Natural Immunity; Persons With Hiv; Telomere Length; Vaccine-Mediated Immunity

$434,655

Program in mammalian telomere biology

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Riabowol, Karl

$288,000

How Does ING5 Promote Cell Stemness?

Nominated PICIHR2016Project Grant

Principal investigators: Riabowol, Karl T

Keywords: Brain Tumor Initiating Cell; Cancer; Chromatin; Epigenetic; Glioblastoma; Ing Proteins; Tumour Suppressor

$100,000

How does ING1a regulate cell senescence?

Nominated PICIHR2013Operating Grant

Principal investigators: Riabowol, Karl T

Keywords: Aging; Cell Senescence; Epigenetic Regulators; Gene Isoforms; Ing1; Lamin A; P53; Tumour Suppressor

$829,036

Single Chain Antibodies to Probe the Molecular Basis of Epigenetics In Living Cells.

Nominated PICIHR2011Catalyst Grant - CEEHRC Epigenetics, Environment & Health

Principal investigators: Riabowol, Karl T

Keywords: Chromatin; Epigenetics; Immunofluorescence; Ing Proteins; Rna Polymerase; Single Cell; Single Chain Antibodies

$97,470

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry and Molecular Biology
Pediatrics
Cell Biology and Anatomy
Pathology and Laboratory Medicine
Medicine
Biochemistry
Genetics
Other

Co-authors at University of Calgary, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Ki-Young Lee

Cell Biology and Anatomy

2 shared papers, latest 2026

Rajiv Midha

Clinical Neurosciences

1 shared papers, latest 2025

Nicolas Touret

Biochemistry

1 shared papers, latest 2025

David Schriemer

Biochemistry and Molecular Biology

1 shared papers, latest 2008

Angela Brooks-Wilson

Pathology and Laboratory Medicine

1 shared papers, latest 2014

Frank Jirik

Biochemistry and Molecular Biology

1 shared papers, latest 2014

Pierre Billon

Biochemistry and Molecular Biology

1 shared papers, latest 2026

Daniel Muruve

Medicine

1 shared papers, latest 2011

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Aging Dear Professor Riabowol, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "OverlappING and DivergING roles of ING4 and ING5 in cancer, differentiation and development." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Stem Cell Function in Biological Aging" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Karl Riabowol

Research

Latest papers

Latest funding

OverlappING and DivergING roles of ING4 and ING5 in cancer, differentiation and development.

Protocol for enhancing CRISPR-Cas9 genome editing using histone deacetylase inhibition and engineered virus-like particle delivery.

Lgmn targets two distinct GPCRs, PAR2 and µ-OR1, and induces cell death in acute lymphoblastic leukemia through an intracellular Ca²⁺ imbalance triggered by ER Ca²⁺ release.

A recently evolved domain of the human ING1 epigenetic regulator targets mitochondria and induces senescence.

FAME-CRISPR improves CRISPR-Cas9 genome editing via HDAC inhibition and engineered virus-like particle delivery.

Functions of TIP60/NuA4 Complex Subunits in Cell Differentiation.

hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan.

Tissue-specific localization of the ING4 targeting subunit of the HBO1 histone acetyltransferase in the cytoplasm and nucleus of secretory cells.

L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand.

Loss of ING3 in the Prostate Leads to Activation of DNA Damage Repair Markers.

Stem Cell Function in Biological Aging

Stem Cell Function in Biological Aging

Oxygen-Regulated Tissue Culturing for Accurate In Virto Cell Analyses

Stem Cell Function in Biological Aging

ING1a mechanisms of cell senescence

Evaluation of COVID-19 antibodies, cell-mediated immunity and telomeres following COVID-19 immunization or natural infection in an immune compromised population: An HIV Cohort Study

Program in mammalian telomere biology

How Does ING5 Promote Cell Stemness?

How does ING1a regulate cell senescence?

Single Chain Antibodies to Probe the Molecular Basis of Epigenetics In Living Cells.

Frequent collaborators

Aru Narendran

Ki-Young Lee

Rajiv Midha

Peter Lansdorp

Gregory Cairncross

Nicolas Touret

David Schriemer

Angela Brooks-Wilson

Frank Jirik

Pierre Billon

Daniel Muruve

Karl Riabowol

Research

Latest papers

Latest funding

OverlappING and DivergING roles of ING4 and ING5 in cancer, differentiation and development.

Protocol for enhancing CRISPR-Cas9 genome editing using histone deacetylase inhibition and engineered virus-like particle delivery.

Lgmn targets two distinct GPCRs, PAR2 and &#xb5;-OR1, and induces cell death in acute lymphoblastic leukemia through an intracellular Ca&#xb2;&#x207a; imbalance triggered by ER Ca&#xb2;&#x207a; release.

A recently evolved domain of the human ING1 epigenetic regulator targets mitochondria and induces senescence.

FAME-CRISPR improves CRISPR-Cas9 genome editing via HDAC inhibition and engineered virus-like particle delivery.

Functions of TIP60/NuA4 Complex Subunits in Cell Differentiation.

hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan.

Tissue-specific localization of the ING4 targeting subunit of the HBO1 histone acetyltransferase in the cytoplasm and nucleus of secretory cells.

L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand.

Loss of ING3 in the Prostate Leads to Activation of DNA Damage Repair Markers.

Oxygen-Regulated Tissue Culturing for Accurate In Virto Cell Analyses

Program in mammalian telomere biology

Frequent collaborators

Aru Narendran

Ki-Young Lee

Rajiv Midha

Peter Lansdorp

Gregory Cairncross

Nicolas Touret

David Schriemer

Angela Brooks-Wilson

Frank Jirik

Pierre Billon

Daniel Muruve

Lgmn targets two distinct GPCRs, PAR2 and µ-OR1, and induces cell death in acute lymphoblastic leukemia through an intracellular Ca²⁺ imbalance triggered by ER Ca²⁺ release.