Faculty profile

Guang Yang

ResearcherMedical GeneticsUniversity of Calgary

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Calgary directory, so their courses may be missing. Find their university profile.

Guang Yang

Researcher

Medical Genetics

Health Sciences

University of Calgary

Calgary, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
12 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 11 research grants (7 NSERC, 4 CIHR), most recently in 2025.
Supervised 1 trainee who won CIHR awards, most recently in 2020.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Disease Mechanisms Brain Development Gene Expression Genetic Disease Modeling Genotype-Phenotype Relationships Neurodevelopmental Disorders Rna Regulation Rna-Binding Protein

Latest papers

Pathological disruption of CELF2 shuttling causes neuronal hyperactivity, learning deficits, and seizures.
The Journal of clinical investigation · 2026 · senior author
Discovery of potential recombinant alleles HLA-DRB3*02:171 and HLA-DRB5*01:140.
HLA · 2024
Reduction of Glyoxalase 1 Expression Links Fetal Methylmercury Exposure to Autism Spectrum Disorder Pathogenesis.
Toxics · 2024

All 17 publications

Latest funding

Mechanistic understanding of pathogenic autophagy and stem cell regulation in a neurodevelopmental disorder
CIHR · 2025 · Nominated PI
$1,078,650
Understanding the Mechanistic Basis for Disease-Causing Variants in CELF2-Related Neurodevelopmental Disorders
CIHR · 2024 · Nominated PI
$929,476
Dissecting neurodevelopmental mechanisms using ultracentrifugation
NSERC · 2024 · Principal investigator
$144,453

All 14 grants and awards

17 publications.

Pathological disruption of CELF2 shuttling causes neuronal hyperactivity, learning deficits, and seizures.

Hua M, Aghanoori MR, MacPherson MJ, Ren Y, Siripala SV, Yang Y, Or YYY, Nguyen M, Duba-Kiss R, Feng D, Williams L, Gafuik CJ, Wang G, Quelin C, Keren B, Schuhmann S, Vasileiou G, Bourgois A, Vitobello A, Philippe C, Stark Z, Leventer RJ, McGillivray G, Tran Mau-Them F, Tessarech M, Prouteau C, Lakeman P, Motazacker MM, Latner DR, Caylor RC, van Ierland Y, Prijoles E, Lichty A, Theodorou E, Sweetser DA, Steel E, Cobben J, Dasouki MJ, Calame DG, Isidor B, Cogné B, Kesler M, Rackel B, Clark I, Kurrasch DM, Teskey GC, Ellis J, He G, Ryan SD, Mahoney DJ, Innes AM, Epp JR, Yang G

The Journal of clinical investigation2026Senior author

DOI: 10.1172/jci199698 PMID: 42275152

Discovery of potential recombinant alleles HLA-DRB302:171 and HLA-DRB501:140.

Hu Q, Abu-Khader A, Christian D, Yang G, Berka N

HLA2024

DOI: 10.1111/tan.15697 PMID: 39291436

Reduction of Glyoxalase 1 Expression Links Fetal Methylmercury Exposure to Autism Spectrum Disorder Pathogenesis.

Leung JW, Loan A, Xu Y, Yang G, Wang J, Chan HM

Toxics2024

DOI: 10.3390/toxics12070449 PMID: 39058101

Generation and characterization of a human iPSC line and gene-corrected isogenic line derived from a patient with a CELF2 gene mutation.

Hua M, Williams L, Burns K, Liu S, Ellis J, Innes AM, McPherson M, Yang G

Stem cell research2024Senior author

DOI: 10.1016/j.scr.2024.103344 PMID: 38364506

Discovery of three novel HLA-DPA1 alleles, HLA-DPA1*01:147N, 01:03:47, and 02:106 using next-generation sequencing.

Hu Q, Burns C, Christian D, Yang G, Berka N

HLA2023

DOI: 10.1111/tan.15125 PMID: 37315941

Identification of four novel HLA-DQ alleles, HLA-DQA101:106, -DQA101:107, -DQA105:74 and -DQB105:01:48.

Hu Q, Christian D, Yang G, Burns C, Berka N

HLA2023

DOI: 10.1111/tan.15076 PMID: 37191269

Two novel HLA class I alleles, HLA-C04:493 and -A26:01:78, identified using next-generation sequencing.

Hu Q, Christian D, Yang G, McKinley C, Berka N

HLA2023

DOI: 10.1111/tan.14985 PMID: 36737403

The P-body protein 4E-T represses translation to regulate the balance between cell genesis and establishment of the postnatal NSC pool.

Kolaj A, Zahr SK, Wang BS, Krawec T, Kazan H, Yang G, Kaplan DR, Miller FD

Cell reports2023

DOI: 10.1016/j.celrep.2023.112242 PMID: 36924490

Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation.

Kedia S, Aghanoori MR, Burns KML, Subha M, Williams L, Wen P, Kopp D, Erickson SL, Harvey EM, Chen X, Hua M, Perez JU, Ishraque F, Yang G

Cell reports2022Senior author

DOI: 10.1016/j.celrep.2022.111070 PMID: 35830814

The novel HLA class II allele, DPB1*1284:01, identified using next-generation sequencing.

Yang G, Abu-Khader A, Burns C, Galaszkiewicz I, Berka N

HLA2022First author

DOI: 10.1111/tan.14587 PMID: 35195350

Mechanistic understanding of pathogenic autophagy and stem cell regulation in a neurodevelopmental disorder

Nominated PICIHR2025Project Grant

Principal investigators: Yang, Guang

Keywords: Autophagy; Cell Differentiation; Deubiquitinase; Disease Mechanisms; Lipid Metabolism; Neural Stem Cells; Neurodevelopmental Disorder; Protein Trafficking; Ubiquitination; Usp15

$1,078,650

Understanding the Mechanistic Basis for Disease-Causing Variants in CELF2-Related Neurodevelopmental Disorders

Nominated PICIHR2024Project Grant

Principal investigators: Yang, Guang

Keywords: Brain Development; Celf2; Disease Mechanisms; Gene Expression; Genetic Disease Modeling; Genotype-Phenotype Relationships; Neurodevelopmental Disorders; Rna Regulation; Rna-Binding Protein

$929,476

Dissecting neurodevelopmental mechanisms using ultracentrifugation

Principal investigatorNSERC2024Research Tools and Instruments

Principal investigators: Yang, Guang

Keywords: brain development; cell differentiation; cilium; environmental factors; gene expression; mRNA translation; neural stem cells; neurodevelopment; subcellular organelles; ultracentrifugation

$144,453

Understanding the Mechanistic Basis for Disease-Causing Variants in CELF2-Related Neurodevelopmental Disorders

Nominated PICIHR2023Operating Grant - PA: Genetics (Bridge Funding: Research Priorities)

Principal investigators: Yang, Guang

Keywords: Brain Development; Disease Mechanisms; Gene Expression; Genetic Disease Modeling; Genotype-Phenotype Relationships; Neurodevelopmental Disorders; Rna Regulation; Rna-Binding Protein

$100,000

Gene Regulation in Brain Development

Principal investigatorNSERC2023Canada Research Chairs

Principal investigators: Yang, Guang

Keywords: Regulation of gene expression; brain development; neurogenesis; neuronal differentiation; cell fate determination; neural stem cells; post-transcriptional control; mRNA regulation; cell signaling; rare neurodevelopmental conditions

$100,000

A pipeline approach for the rational design of neuronal lineage conversion approaches to treat neurological disorders

Co-investigatorSSHRC2022New Frontiers in Research Fund - Transformation

Principal investigators: Schuurmans, Carol

Keywords: neurodegenerative disease,; Alzheimer's disease; direct neuronal reprogramming; transcription factors; gene regulatory networks ; computer-guided design; nanoparticles; epigenomics ; neurological disorders; self-amplifying RNA; bacteriophage; astrocytes; stroke; epilepsy; focused ultrasound

$8,000,000

Targeting the Mislocalized Protein to Fight a Rare Neurodevelopmental Disorder

SupervisorCIHR2020CIHR Fellowship

Principal investigators: Aghanoori, Mohamadreza

Keywords: Celf2; Central Nervous System; Cortical Patterns; Diagnosis And Treatment; Molecular Mechanism; Nucleocytoplasmic Shuttling; Rare Neurodevelopmental Disorder; Rna Biology; Translatome

$135,000

Modelling Mitochondrial Disease

Co-investigatorCIHR2019Project Grant

Principal investigators: Shutt, Timothy E

Keywords: Mitochondria; Mitochondrial Disease; Mitochondrial Dynamics

$822,376

Understanding the translational mechanisms of neuronal subtype specification in the mammalian cortex

Nominated PICIHR2019Project Grant

Principal investigators: Yang, Guang

Keywords: Brain Development; Fate Specification; Neuronal Subtype Specification; Rna-Binding Proteins; Translational Regulation

$791,776

Regulatory Genomics

Principal investigatorNSERC2018Canada Research Chairs

Principal investigators: Yang, Guang

$360,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Something wrong or missing on this profile? Suggest a correction

Guang Yang

Research

Latest papers

Latest funding

Pathological disruption of CELF2 shuttling causes neuronal hyperactivity, learning deficits, and seizures.

Discovery of potential recombinant alleles HLA-DRB302:171 and HLA-DRB501:140.

Reduction of Glyoxalase 1 Expression Links Fetal Methylmercury Exposure to Autism Spectrum Disorder Pathogenesis.

Generation and characterization of a human iPSC line and gene-corrected isogenic line derived from a patient with a CELF2 gene mutation.

Discovery of three novel HLA-DPA1 alleles, HLA-DPA1*01:147N, 01:03:47, and 02:106 using next-generation sequencing.

Identification of four novel HLA-DQ alleles, HLA-DQA101:106, -DQA101:107, -DQA105:74 and -DQB105:01:48.

Two novel HLA class I alleles, HLA-C04:493 and -A26:01:78, identified using next-generation sequencing.

The P-body protein 4E-T represses translation to regulate the balance between cell genesis and establishment of the postnatal NSC pool.

Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation.

The novel HLA class II allele, DPB1*1284:01, identified using next-generation sequencing.

Mechanistic understanding of pathogenic autophagy and stem cell regulation in a neurodevelopmental disorder

Understanding the Mechanistic Basis for Disease-Causing Variants in CELF2-Related Neurodevelopmental Disorders

Dissecting neurodevelopmental mechanisms using ultracentrifugation

Understanding the Mechanistic Basis for Disease-Causing Variants in CELF2-Related Neurodevelopmental Disorders

Gene Regulation in Brain Development

A pipeline approach for the rational design of neuronal lineage conversion approaches to treat neurological disorders

Targeting the Mislocalized Protein to Fight a Rare Neurodevelopmental Disorder

Modelling Mitochondrial Disease

Understanding the translational mechanisms of neuronal subtype specification in the mammalian cortex

Regulatory Genomics

Frequent collaborators

James Ellis

Quan Long

Jing Wang

Guang Yang

Research

Latest papers

Latest funding

Pathological disruption of CELF2 shuttling causes neuronal hyperactivity, learning deficits, and seizures.

Discovery of potential recombinant alleles HLA-DRB3*02:171 and HLA-DRB5*01:140.

Reduction of Glyoxalase 1 Expression Links Fetal Methylmercury Exposure to Autism Spectrum Disorder Pathogenesis.

Generation and characterization of a human iPSC line and gene-corrected isogenic line derived from a patient with a CELF2 gene mutation.

Discovery of three novel HLA-DPA1 alleles, HLA-DPA1*01:147N, 01:03:47, and 02:106 using next-generation sequencing.

Identification of four novel HLA-DQ alleles, HLA-DQA1*01:106, -DQA1*01:107, -DQA1*05:74 and -DQB1*05:01:48.

Two novel HLA class I alleles, HLA-C*04:493 and -A*26:01:78, identified using next-generation sequencing.

The P-body protein 4E-T represses translation to regulate the balance between cell genesis and establishment of the postnatal NSC pool.

Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation.

The novel HLA class II allele, DPB1*1284:01, identified using next-generation sequencing.

Mechanistic understanding of pathogenic autophagy and stem cell regulation in a neurodevelopmental disorder

Understanding the Mechanistic Basis for Disease-Causing Variants in CELF2-Related Neurodevelopmental Disorders

Dissecting neurodevelopmental mechanisms using ultracentrifugation

Understanding the Mechanistic Basis for Disease-Causing Variants in CELF2-Related Neurodevelopmental Disorders

Gene Regulation in Brain Development

A pipeline approach for the rational design of neuronal lineage conversion approaches to treat neurological disorders

Targeting the Mislocalized Protein to Fight a Rare Neurodevelopmental Disorder

Modelling Mitochondrial Disease

Understanding the translational mechanisms of neuronal subtype specification in the mammalian cortex

Regulatory Genomics

Frequent collaborators

James Ellis

Quan Long

Jing Wang

Discovery of potential recombinant alleles HLA-DRB302:171 and HLA-DRB501:140.

Identification of four novel HLA-DQ alleles, HLA-DQA101:106, -DQA101:107, -DQA105:74 and -DQB105:01:48.

Two novel HLA class I alleles, HLA-C04:493 and -A26:01:78, identified using next-generation sequencing.