Henry Duff, University of Calgary

Latest papers

Identification and in-silico characterization of splice-site variants from a large cardiogenetic national registry
European Journal of Human Genetics · 2023
Return of Results Policies for Genomic Research: Current Practices and the Hearts in Rhythm Organization (HiRO) Approach
Canadian Journal of Cardiology · 2022
Short-coupled ventricular fibrillation represents a distinct phenotype among latent causes of unexplained cardiac arrest: a report from the CASPER registry
European Heart Journal · 2021

All 11 publications

Latest funding

Modulators of hERG/HCN4 Function and Block
NSERC · 2017 · Principal investigator
$140,000
Lipid-dependent modulation of cardiac ion channel activity as an anti-arrhythmic therapy in long-QT syndrome
CIHR · 2017 · Co-investigator
$669,375
Mapping of the structure - function role of important selected ion channels for normal physiology
NSERC · 2016 · Principal investigator
$31,000

All 5 grants and awards

11 publications.

01

Identification and in-silico characterization of splice-site variants from a large cardiogenetic national registry

Rayani K, Davies B, Cheung M, Comber D, Roberts JD, Tadros R, Green MS, Healey JS, Simpson CS, Sanatani S

European Journal of Human Genetics20237 citations

DOI: 10.1038/s41431-022-01193-9

02

Return of Results Policies for Genomic Research: Current Practices and the Hearts in Rhythm Organization (HiRO) Approach

Comber DA, Davies B, Roberts JD, Tadros R, Green MS, Healey JS, Simpson CS, Sanatani S, Steinberg C, MacIntyre C

Canadian Journal of Cardiology20225 citations

DOI: 10.1016/j.cjca.2021.10.006

03

Short-coupled ventricular fibrillation represents a distinct phenotype among latent causes of unexplained cardiac arrest: a report from the CASPER registry

Steinberg C, Davies B, Mellor G, Tadros R, Laksman ZW, Roberts JD, Green M, Alqarawi W, Angaran P, Healey J

European Heart Journal202189 citations

DOI: 10.1093/eurheartj/ehab275

04

The Hearts in Rhythm Organization: A Canadian National Cardiogenetics Network

Davies B, Roberts JD, Tadros R, Green MS, Healey JS, Simpson CS, Sanatani S, Steinberg C, MacIntyre C, Angaran P

CJC Open202027 citations

DOI: 10.1016/j.cjco.2020.05.006

05

Early Repolarization Pattern Inheritance in the Cardiac Arrest Survivors With Preserved Ejection Fraction Registry (CASPER)

Malhi N, So PP, Cheung CC, Laksman ZWM, Healey JS, Chauhan VS, Green MS, Champagne J, Steinberg C, Sanatani S

JACC: Clinical Electrophysiology20189 citations

DOI: 10.1016/j.jacep.2018.07.001

06

Randomized Crossover Trial of Blood Volume Monitoring-Guided Ultrafiltration Biofeedback to Reduce Intradialytic Hypotensive Episodes with Hemodialysis.

Leung KCW, Quinn RR, Ravani P, Duff H, MacRae JM

Clinical journal of the American Society of Nephrology : CJASN2017

DOI: 10.2215/cjn.01030117 PMID: 29018100

07

Ankyrin-B Defects: Serendipity and Inquisitiveness are the Mothers of Invention.

Duff H, Sheldon RS

Circulation. Cardiovascular genetics2017First author

DOI: 10.1161/circgenetics.117.001698 PMID: 28196903

08

Statin Induced Regression of Cardiomyopathy Trial: A Randomized, Placebo-controlled Double-blind Trial.

Hersi A, Giannoccaro JP, Howarth A, Exner D, Weeks S, Eitel I, Herman RC, Duff H, Ritchie D, Mcrae M, Sheldon R

Heart views : the official journal of the Gulf Heart Association2016

DOI: 10.4103/1995-705x.201784 PMID: 28400935

09

Dissociative States: hERG Channel (Kv11.1) Modulators That Enhance Dissociation of Drugs From Their Blocking Receptor: Potential New Therapeutic Drugs.

Rezazadeh S, Duff H

Circulation. Arrhythmia and electrophysiology2016Senior author

DOI: 10.1161/circep.116.004003 PMID: 27071827

10

Early repolarization syndrome: A case report focusing on dynamic electrocardiographic changes before ventricular arrhythmias and genetic analysis.

Tan VH, Duff H, Gerull B, Sumner G

HeartRhythm case reports2015

DOI: 10.1016/j.hrcr.2015.03.001 PMID: 28491551

Modulators of hERG/HCN4 Function and Block

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Duff, Henry

$140,000

Lipid-dependent modulation of cardiac ion channel activity as an anti-arrhythmic therapy in long-QT syndrome

Co-investigatorCIHR2017Project Grant

Principal investigators: Noskov, Sergei

Keywords: Electrophysiology; Fatty Acids; Long-Qt Syndrome; Molecular Modelling; Molecular Pharmacology; Pharmacology; Potassium Channels

$669,375

Mapping of the structure - function role of important selected ion channels for normal physiology

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Duff, Henry

$31,000

Small molecule control of the functional dynamics in cardiac potassium channels.

Co-investigatorCIHR2011Operating Grant

Principal investigators: Noskov, Sergei

Keywords: Cardiac Electrophysiology; Cardiac Potassium Channels; Cardiotoxicity; Drug Development; Molecular Biophysics; Molecular Modeling; Molecular Pharmacology

$558,167

Molecular Mechanism of Drug Blockade and Activation in Voltage-gated Potassium Channels

SupervisorCIHR2009CIHR Fellowship

Principal investigators: Durdagi, Serdar

Keywords: Cardiology; De-Novo Drug Design; In Silico Docking; Ion Channels; Membrane Biochemistry; Membranes; Molecular Dynamics (Md) Simulations; Protein-Ligand Interactions; Rational Drug Design; Structute/Function

$135,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Pediatrics
Cardiac Sciences
Medical Genetics
Cardiology
Department of Medicine
Medicine/Cardiology
Other

Applying for

Paper to mention

Subject: Prospective PhD student Dear Professor Duff, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Identification and in-silico characterization of splice-site variants from a large cardiogenetic national registry" (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]