Myriam Hemberger, University of Calgary

Research

Crc Chromatin Organization Decidualization Dna Methylation Epigenome Gene Regulation Maternal Age Pregnancy

Latest papers

The imprinted Peg3 gene is a potent regulator of the DNA methylome in trophoblast cells.
Stem cell reports · 2026 · senior author
Differential DNA methylation and gene expression in stem cell-derived cardiomyocytes from patients with and without a history of clozapine-induced myocarditis.
Journal of psychiatry & neuroscience : JPN · 2025
Active chromatin marks and up-regulation of FOXC1 in uterine epithelial cells demarcate the onset of reproductive decline in aging females.
NAR molecular medicine · 2025 · senior author

All 33 publications

Latest funding

Canada Research Chair - Tier 1
CIHR · 2025 · Nominated PI
$1,400,000
Epigenetic Control of Development: Establishment and function of placenta-specific DNA methylation patterns
NSERC · 2021 · Principal investigator
$232,000
Epigenomic changes trigger a decline in uterine function and reproductive health in females of advanced maternal age
CIHR · 2020 · Nominated PI
$868,275

All 4 grants and awards

33 publications.

01

The imprinted Peg3 gene is a potent regulator of the DNA methylome in trophoblast cells.

Kokorudz C, Ballasy N, Radford BN, Jadli AS, Krala A, Narang A, Dean W, Hemberger M

Stem cell reports2026Senior author

DOI: 10.1016/j.stemcr.2026.103021 PMID: 42492511

02

Differential DNA methylation and gene expression in stem cell-derived cardiomyocytes from patients with and without a history of clozapine-induced myocarditis.

Marques D, Spindola L, Narang A, Vaziri N, Stavrum A, Jayaram M, Thomas N, Pantelis C, Le Hellard S, Hemberger M, Dean W, Greenway S, Bousman C

Journal of psychiatry & neuroscience : JPN2025

DOI: 10.1139/jpn-25-0017 PMID: 41170773

03

Active chromatin marks and up-regulation of FOXC1 in uterine epithelial cells demarcate the onset of reproductive decline in aging females.

Tsolova AO, Lea G, Jadli AS, Mastrokolias A, Narang A, Krala A, Radford BN, Hanna CW, Kelsey GD, Critchley HOD, Dean W, Hemberger M

NAR molecular medicine2025Senior author

DOI: 10.1093/narmme/ugaf031 PMID: 40922722

04

A roadmap towards targeted differentiation of mouse trophoblast stem cells into cell types of the feto-maternal exchange surface.

Ballasy N, Radford BN, Mohammad S, Dean W, Hemberger M

Stem cell research & therapy2025Senior author

DOI: 10.1186/s13287-025-04487-z PMID: 40660370

05

Phospholipid flippase ATP11A brokers uterine epithelial integrity and function.

Krala A, Tsolova AO, Radford BN, Jadli AS, Zhao X, Blackwell D, Narang A, Dean W, Hemberger M

Proceedings of the National Academy of Sciences of the United States of America2025Senior author

DOI: 10.1073/pnas.2420617122 PMID: 40261925

06

Single-cell RNA sequencing identifies CXADR as a fate determinant of the placental exchange surface.

Angelova DM, Tsolova A, Prater M, Ballasy N, Bacon W, Hamilton RS, Blackwell D, Yu Z, Li X, Liu X, Hemberger M, Charnock-Jones DS

Nature communications2025

DOI: 10.1038/s41467-024-55597-w PMID: 39747179

07

Off to a good start: The importance of the placental exchange surface - Lessons from the mouse.

Ballasy N, Apantaku I, Dean W, Hemberger M

Developmental biology2025Senior author

DOI: 10.1016/j.ydbio.2024.10.009 PMID: 39491740

08

REPRODUCTIVE AGEING: Altered histone modification landscapes underpin defects in uterine stromal cell decidualization in aging females.

Woods L, Dean W, Hemberger M

Reproduction (Cambridge, England)2024Senior author

DOI: 10.1530/rep-24-0171 PMID: 38995736

09

The GPI-anchor biosynthesis pathway is critical for syncytiotrophoblast differentiation and placental development.

Álvarez-Sánchez A, Grinat J, Doria-Borrell P, Mellado-López M, Pedrera-Alcócer É, Malenchini M, Meseguer S, Hemberger M, Pérez-García V

Cellular and molecular life sciences : CMLS2024

DOI: 10.1007/s00018-024-05284-2 PMID: 38819479

10

Generation of Knockout Mouse Trophoblast Stem Cells by CRISPR/Cas9.

Doria-Borrell P, Moya-Navamuel M, Hemberger M, Pérez-García V

Methods in molecular biology (Clifton, N.J.)2024

DOI: 10.1007/978-1-0716-3746-3_8 PMID: 38502445

Canada Research Chair - Tier 1

Nominated PICIHR2025Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Hemberger, Myriam

Keywords: Crc

$1,400,000

Epigenetic Control of Development: Establishment and function of placenta-specific DNA methylation patterns

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Hemberger, Myriam

$232,000

Epigenomic changes trigger a decline in uterine function and reproductive health in females of advanced maternal age

Nominated PICIHR2020Project Grant

Principal investigators: Hemberger, Myriam

Keywords: Chromatin Organization; Decidualization; Dna Methylation; Epigenome; Gene Regulation; Maternal Age; Pregnancy; Progesterone Resistance

$868,275

Canada Research Chair Tier 1

Nominated PICIHR2018Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Hemberger, Myriam

Keywords: Crc

$1,400,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry and Molecular Biology
Dentistry
Cell Biology and Anatomy
Medical Genetics
Comparative Biology and Experimental Medicine
Other

Co-authors at University of Calgary, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Chad Bousman

Medical Genetics

1 shared papers, latest 2025

Mark Ungrin

Comparative Biology and Experimental Medicine

1 shared papers, latest 2023

Benedikt Hallgrimsson

Cell Biology and Anatomy

1 shared papers, latest 2023

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Crc Dear Professor Hemberger, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The imprinted Peg3 gene is a potent regulator of the DNA methylome in trophoblast cells." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Canada Research Chair - Tier 1" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Myriam Hemberger

Research

Latest papers

Latest funding

The imprinted Peg3 gene is a potent regulator of the DNA methylome in trophoblast cells.

Differential DNA methylation and gene expression in stem cell-derived cardiomyocytes from patients with and without a history of clozapine-induced myocarditis.

Active chromatin marks and up-regulation of FOXC1 in uterine epithelial cells demarcate the onset of reproductive decline in aging females.

A roadmap towards targeted differentiation of mouse trophoblast stem cells into cell types of the feto-maternal exchange surface.

Phospholipid flippase ATP11A brokers uterine epithelial integrity and function.

Single-cell RNA sequencing identifies CXADR as a fate determinant of the placental exchange surface.

Off to a good start: The importance of the placental exchange surface - Lessons from the mouse.

REPRODUCTIVE AGEING: Altered histone modification landscapes underpin defects in uterine stromal cell decidualization in aging females.

The GPI-anchor biosynthesis pathway is critical for syncytiotrophoblast differentiation and placental development.

Generation of Knockout Mouse Trophoblast Stem Cells by CRISPR/Cas9.

Canada Research Chair - Tier 1

Epigenetic Control of Development: Establishment and function of placenta-specific DNA methylation patterns

Epigenomic changes trigger a decline in uterine function and reproductive health in females of advanced maternal age

Canada Research Chair Tier 1

Frequent collaborators

Daniel Graf

Chad Bousman

Mark Ungrin

Janet Rossant

Benedikt Hallgrimsson