Faculty profile
Nicholas Harden
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Latest papers
Evolutionary conservation of systemic and reversible amyloid aggregation.
Journal of cell science · 2021
20-hydroxyecdysone (20E) signaling regulates amnioserosa morphogenesis during Drosophila dorsal closure: EcR modulates gene expression in a complex with the AP-1 subunit, Jun.
Biology open · 2021
Hyperpolarized mitochondria accumulate in Drosophila Hipk-overexpressing cells to drive tumor-like growth.
Journal of cell science · 2020
Latest funding
- $150,000
High-pressure freezing unit for visualizing cellular ultrastructure by electron microscopy
NSERC · 2019 · Co-investigator
- $300,000
Regulation of tissue morphogenesis by non-canonical steroid hormone signaling in Drosophila
NSERC · 2018 · Principal investigator
- $150,000
A super-resolution microscope for visualizing cellular structure and dynamics
NSERC · 2017 · Co-investigator
18 publications.
Evolutionary conservation of systemic and reversible amyloid aggregation.
Lacroix E, Pereira L, Yoo B, Coyle KM, Chandhok S, Zapf R, Marijan D, Morin RD, Vlachos S, Harden N, Audas TE
20-hydroxyecdysone (20E) signaling regulates amnioserosa morphogenesis during Drosophila dorsal closure: EcR modulates gene expression in a complex with the AP-1 subunit, Jun.
Yoo B, Kim HY, Chen X, Shen W, Jang JS, Stein SN, Cormier O, Pereira L, Shih CRY, Krieger C, Reed B, Harden N, Wang SJH
Hyperpolarized mitochondria accumulate in Drosophila Hipk-overexpressing cells to drive tumor-like growth.
Wong KKL, Liao JZ, Shih CRY, Harden N, Verheyen EM
Homeodomain-interacting protein kinase (Hipk) plays roles in nervous system and muscle structure and function.
Wang SJH, Sinclair DAR, Kim HY, Kinsey SD, Yoo B, Shih CRY, Wong KKL, Krieger C, Harden N, Verheyen EM
Studying Nonproliferative Roles for Egfr Signaling in Tissue Morphogenesis Using Dorsal Closure of the Drosophila Embryo.
Reed B, Harden N
New Insights from Drosophila into the Regulation of EGFR Signaling.
Harden N
Making the connection - shared molecular machinery and evolutionary links underlie the formation and plasticity of occluding junctions and synapses.
Harden N, Wang SJ, Krieger C
Corrigendum to ''The serine/threonine kinase dPak is required for polarized assembly of F-actin bundles and apical-basal polarity in the Drosophila follicular epithelium'' [Dev. Biol. 305 (2007) 470-482].
Conder R, Yu H, Zahedi B, Harden N
Adducin at the Neuromuscular Junction in Amyotrophic Lateral Sclerosis: Hanging on for Dear Life.
Krieger C, Wang SJ, Yoo SH, Harden N
A Pak-regulated cell intercalation event leading to a novel radial cell polarity is involved in positioning of the follicle stem cell niche in the Drosophila ovary.
Vlachos S, Jangam S, Conder R, Chou M, Nystul T, Harden N
High-pressure freezing unit for visualizing cellular ultrastructure by electron microscopy
Principal investigators: Beh, Christopher
Regulation of tissue morphogenesis by non-canonical steroid hormone signaling in Drosophila
Principal investigators: Harden, Nicholas
A super-resolution microscope for visualizing cellular structure and dynamics
Principal investigators: Beh, Christopher
Characterization of Pak kinase regulation of epithelial morphogenesis during Drosophila oogenesis
Principal investigators: Harden, Nicholas
Characterization of effector kinases for the Rho family small GTPases in a Drosophila model of wound healing
Principal investigators: Harden, Nicholas
Keywords: Diverse Malignancies And Birth Defects; Drosophila Developmental Genetics; Nonreceptor Tyrosine Kinase Ack; Serine/Threonine Kinase Pak; Signal Transduction By Rho Family Small Gtpases; Wound Healing
Characterization of pak kinase function in drosophila oogenesis
Principal investigators: Harden, Nicholas
CCD camera and software for imaging drosophila development
Principal investigators: Verheyen, Esther
Analysis of the roles of Rho family small GTPase signaling in drosophila epithelial morphogenesis
Principal investigators: Harden, Nicholas
Preparative centrifuge for molecular biology
Principal investigators: Smith, Michael
Analysis of the roles of the Rho subfamily of the Ras-related small GTPases in Drosophila development.
Principal investigators: Harden, Nicholas
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Nicholas Harden and Charles Krieger: 6 shared papers
- Nicholas Harden and Bruce Reed: 2 shared papers
- Caillin Langmann and Nicholas Harden: 1 shared paper
- Bryan Stewart and Nicholas Harden: 1 shared paper
- Bryan Stewart and Charles Krieger: 1 shared paper
- Bruce Reed and Charles Krieger: 1 shared paper
- Department of Molecular Biology and Biochemistry
- Department of Biomedical Physiology and Kinesiology
- Biology
- Department of Biology
- Department of Medicine
Co-authors at Simon Fraser University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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