Adam Frankel, University of British Columbia

Research

Read how they describe their research on their University of British Columbia profile.

Latest papers

Denaturation, rapid dilution refolding, and single-step purification of the core histones using desalting size-exclusion chromatography.
Methods (San Diego, Calif.) · 2026
Structure, Function, and Activity of Small Molecule and Peptide Inhibitors of Protein Arginine Methyltransferase 1.
Journal of medicinal chemistry · 2024
Investigating Protein Binding with the Isothermal Ligand-induced Resolubilization Assay.
Chembiochem : a European journal of chemical biology · 2024 · senior author

All 27 publications

Latest funding

Overcoming Dihydrofolate Reductase Inhibitor Resistance Using Pyrimethamine-inspired Proteolysis Targeting Chimeras
CIHR · 2021 · Co-investigator
$812,814
Biomolecular Imaging System for Nanomedicine and Chemical Biology Applications in Pharmaceutical Sciences
NSERC · 2021 · Principal investigator
$144,803
Methylarginine Dynamics in Cellular Processes
NSERC · 2020 · Principal investigator
$160,000

All 5 grants and awards

27 publications.

01

Denaturation, rapid dilution refolding, and single-step purification of the core histones using desalting size-exclusion chromatography.

Ige OO, Hendrickson-Rebizant T, Luo W, Oyeyode M, Jacobson S, Ortiz Bada FM, Rowley MJ, Liu RW, Davie JR, Frankel A, Lakowski TM

Methods (San Diego, Calif.)2026

DOI: 10.1016/j.ymeth.2025.12.003 PMID: 41386538

02

Structure, Function, and Activity of Small Molecule and Peptide Inhibitors of Protein Arginine Methyltransferase 1.

Hendrickson-Rebizant T, Sudhakar SRN, Rowley MJ, Frankel A, Davie JR, Lakowski TM

Journal of medicinal chemistry2024

DOI: 10.1021/acs.jmedchem.4c00490 PMID: 39250434

03

Investigating Protein Binding with the Isothermal Ligand-induced Resolubilization Assay.

Prout-Holm RA, van Walstijn CC, Hitsman A, Rowley MJ, Olsen JE, Page BDG, Frankel A

Chembiochem : a European journal of chemical biology2024Senior author

DOI: 10.1002/cbic.202300773 PMID: 38266114

04

Investigating the anti-cancer potential of pyrimethamine analogues through a modern chemical biology lens.

Brown JI, Persaud R, Iliev P, Karmacharya U, Attarha S, Sahile H, Olsen JE, Hanke D, Idowu T, Frank DA, Frankel A, Williams KC, Page BDG

European journal of medicinal chemistry2024

DOI: 10.1016/j.ejmech.2023.115971 PMID: 38071795

05

Protein arginine N-methyltransferase 2 plays a noncatalytic role in the histone methylation activity of PRMT1.

Rowley MJ, Prout-Holm RA, Liu RW, Hendrickson-Rebizant T, Ige OO, Lakowski TM, Frankel A

The Journal of biological chemistry2023Senior author

DOI: 10.1016/j.jbc.2023.105360 PMID: 37863263

06

Methylarginine efflux in nutrient-deprived yeast mitigates disruption of nitric oxide synthesis.

Brown JI, Alibhai J, Zhu E, Frankel A

Amino acids2023Senior author

DOI: 10.1007/s00726-022-03220-x PMID: 36454288

07

Protein arginine N-methyltransferase activity determination with filter binding and phosphor screening (FBAPS) assay.

Rowley MJ, Taylor SA, Frankel A

Analytical biochemistry2022Senior author

DOI: 10.1016/j.ab.2022.114778 PMID: 35709928

08

Protein arginine methyltransferase 8 modulates mitochondrial bioenergetics and neuroinflammation after hypoxic stress.

Couto E Silva A, Wu CY, Clemons GA, Acosta CH, Chen CT, Possoit HE, Citadin CT, Lee RH, Brown JI, Frankel A, Lin HW

Journal of neurochemistry2021

DOI: 10.1111/jnc.15462 PMID: 34216036

09

Biological and chemical approaches to understanding protein arginine methylation.

Frankel A

Methods (San Diego, Calif.)2020First author

DOI: 10.1016/j.ymeth.2020.02.001 PMID: 32032700

10

The application of differential scanning fluorimetry in exploring bisubstrate binding to protein arginine N-methyltransferase 1.

Brown JI, Page BDG, Frankel A

Methods (San Diego, Calif.)2020Senior author

DOI: 10.1016/j.ymeth.2019.11.004 PMID: 31726226

Overcoming Dihydrofolate Reductase Inhibitor Resistance Using Pyrimethamine-inspired Proteolysis Targeting Chimeras

Co-investigatorCIHR2021Project Grant

Principal investigators: Page, Brent

Keywords: Chemical Biology; Drug Discovery; Drug Repurposing; Drug Resistance; Medicinal Chemistry; Proteolysis Targeting Chimeras (Protacs); Target Engagement Assays

$812,814

Biomolecular Imaging System for Nanomedicine and Chemical Biology Applications in Pharmaceutical Sciences

Principal investigatorNSERC2021Research Tools and Instruments

Principal investigators: Frankel, Adam

$144,803

Methylarginine Dynamics in Cellular Processes

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Frankel, Adam

Keywords: arginine methylation; yeast; post-translational modification; autophagy; vacuole; mitochondrion; nitric oxide; gene knockout; mass spectrometry; amino acids

$160,000

Dynamics of Arginine Methylation in Cellular Processes

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Frankel, Adam

$150,000

Dynamics of Arginine Methylation in Cellular Processes

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Frankel, Adam

$35,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Pharmsci
Medicine
Physiology

Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Henok Sahile

Medicine

1 shared papers, latest 2024

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2021

Subject: Prospective PhD student Dear Professor Frankel, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Denaturation, rapid dilution refolding, and single-step purification of the core histones using desalting size-exclusion chromatography." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Biomolecular Imaging System for Nanomedicine and Chemical Biology Applications in Pharmaceutical Sciences" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Adam Frankel

Research

Latest papers

Latest funding

Denaturation, rapid dilution refolding, and single-step purification of the core histones using desalting size-exclusion chromatography.

Structure, Function, and Activity of Small Molecule and Peptide Inhibitors of Protein Arginine Methyltransferase 1.

Investigating Protein Binding with the Isothermal Ligand-induced Resolubilization Assay.

Investigating the anti-cancer potential of pyrimethamine analogues through a modern chemical biology lens.

Protein arginine N-methyltransferase 2 plays a noncatalytic role in the histone methylation activity of PRMT1.

Methylarginine efflux in nutrient-deprived yeast mitigates disruption of nitric oxide synthesis.

Protein arginine N-methyltransferase activity determination with filter binding and phosphor screening (FBAPS) assay.

Protein arginine methyltransferase 8 modulates mitochondrial bioenergetics and neuroinflammation after hypoxic stress.

Biological and chemical approaches to understanding protein arginine methylation.

The application of differential scanning fluorimetry in exploring bisubstrate binding to protein arginine N-methyltransferase 1.

Overcoming Dihydrofolate Reductase Inhibitor Resistance Using Pyrimethamine-inspired Proteolysis Targeting Chimeras

Biomolecular Imaging System for Nanomedicine and Chemical Biology Applications in Pharmaceutical Sciences

Methylarginine Dynamics in Cellular Processes

Dynamics of Arginine Methylation in Cellular Processes

Dynamics of Arginine Methylation in Cellular Processes

Frequent collaborators

Jinrong Min

Henok Sahile