Alexander Scott, University of British Columbia

Research

Tendinopathy Animal Models Mast Cells Musculoskeletal System Overuse Injuries Tendon Hypercholesterolemia Inflammation

Latest papers

Understanding the impact of Achilles lipid content on tendon mechanical parameters: a cross-sectional study of people with familial hypercholesterolemia and healthy controls.
BMC musculoskeletal disorders · 2025 · senior author
Osteoarthritic Tibiofemoral Joint Contact Characteristics During Weightbearing With Arch-Supported and Standalone Lateral Wedge Insoles.
Journal of applied biomechanics · 2024
In vitro collagen biomarkers in mechanically stimulated human tendon cells: a systematic review.
Connective tissue research · 2024 · senior author

All 25 publications

Latest funding

Tendon impairment in people with familal hypercholesterolemia: clinical and laboratory studies
CIHR · 2019 · Nominated PI
$646,426
Tendon cell mechanotransduction
NSERC · 2018 · Principal investigator
$42,134
Tendon physiology and biomechanics
NSERC · 2017 · Principal investigator
$120,000

All 12 grants and awards

25 publications.

01

Understanding the impact of Achilles lipid content on tendon mechanical parameters: a cross-sectional study of people with familial hypercholesterolemia and healthy controls.

Squier K, Waugh C, Callow J, Patola W, Hunt MA, Brunham LR, Jakobi J, Scott A

BMC musculoskeletal disorders2025Senior author

DOI: 10.1186/s12891-025-08430-4 PMID: 39987058

02

Osteoarthritic Tibiofemoral Joint Contact Characteristics During Weightbearing With Arch-Supported and Standalone Lateral Wedge Insoles.

Tse CTF, Ryan MB, Krowchuk NM, Scott A, Hunt MA

Journal of applied biomechanics2024

DOI: 10.1123/jab.2023-0168 PMID: 38834183

03

In vitro collagen biomarkers in mechanically stimulated human tendon cells: a systematic review.

Squier K, Mousavizadeh R, Damji F, Beck C, Hunt M, Scott A

Connective tissue research2024Senior author

DOI: 10.1080/03008207.2024.2313582 PMID: 38375562

04

Clinically-accessible and laboratory-derived predictors of biomechanical response to standalone and supported lateral wedge insoles in people with knee osteoarthritis.

Hunt MA, Tse CTF, Ryan MB, Scott A, Sayre EC

Journal of foot and ankle research2023

DOI: 10.1186/s13047-023-00671-7 PMID: 37885001

05

The impact of mild hypercholesterolemia on injury repair in the rat patellar tendon.

Waugh CM, Mousavizadeh R, Lee J, Screen HRC, Scott A

Journal of orthopaedic research : official publication of the Orthopaedic Research Society2023Senior author

DOI: 10.1002/jor.25546 PMID: 36866829

06

Mild hypercholesterolemia impacts achilles sub-tendon mechanical properties in young rats.

Waugh CM, Mousavizadeh R, Lee J, Screen HRC, Scott A

BMC musculoskeletal disorders2023Senior author

DOI: 10.1186/s12891-023-06375-0 PMID: 37046262

07

Case Studies in Physiology: Adaptation of load-bearing tendons during pregnancy.

Waugh CM, Scott A

Journal of applied physiology (Bethesda, Md. : 1985)2022Senior author

DOI: 10.1152/japplphysiol.00555.2021 PMID: 35271408

08

Multiple Functional Brain Networks Related to Pain Perception Revealed by fMRI.

Damascelli M, Woodward TS, Sanford N, Zahid HB, Lim R, Scott A, Kramer JK

Neuroinformatics2022

DOI: 10.1007/s12021-021-09527-6 PMID: 34101115

09

The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study.

Squier K, Scott A, Hunt MA, Brunham LR, Wilson DR, Screen H, Waugh CM

PloS one2021

DOI: 10.1371/journal.pone.0257269 PMID: 34529718

10

Transverse tendon stiffness is reduced in people with Achilles tendinopathy: A cross-sectional study.

Finnamore E, Waugh C, Solomons L, Ryan M, West C, Scott A

PloS one2019Senior author

DOI: 10.1371/journal.pone.0211863 PMID: 30785895

Tendon impairment in people with familal hypercholesterolemia: clinical and laboratory studies

Nominated PICIHR2019Project Grant

Principal investigators: Scott, Alexander

Keywords: Hypercholesterolemia; Tendinopathy

$646,426

Tendon cell mechanotransduction

Principal investigatorNSERC2018Research Tools and Instruments

Principal investigators: Scott, Alexander

$42,134

Tendon physiology and biomechanics

Principal investigatorNSERC2017Discovery Grants Program - Accelerator Supplements

Principal investigators: Scott, Alex

$120,000

Tendon physiology and biomechanics

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Scott, Alexander

$312,000

The influence of hypercholesterolemia on characteristics of tendon health

SupervisorCIHR2017Undergraduate: Summer Studentship Award - Institute Community Support

Principal investigators: Lee, Jenny J

Keywords: Tendon - Pathophysiology

$5,000

Impact of oxidized LDL on mechanically induced collagen synthesis: an in vitro study of human tendon fibroblasts

SupervisorCIHR2015Undergraduate: Summer Studentship Award - Institute Community Support

Principal investigators: Kobza, Alexandra O

Keywords: Ics Studentship

$5,000

Role of mast cells in tendinopathy

Nominated PICIHR2014Operating Grant - PA: IMHA - New Invest.- Musculoskeletal Health Bridge Funding

Principal investigators: Scott, Alexander; McNagny, Kelly M

Keywords: Animal Models; Mast Cells; Musculoskeletal System; Overuse Injuries; Tendinopathy; Tendon

$100,000

Role of mast cells in Achilles tendinopathy

Nominated PICIHR2012Operating Grant - PA: IMHA New investigators - Bridge Funding

Principal investigators: Scott, Alexander; McNagny, Kelly M

Keywords: Animal Models; Inflammation; Mast Cells; Musculoskeletal System; Overuse Injuries; Tendinopathy; Tendon

$100,000

Feasibility of a randomized controlled trial of ketotifen for lateral epicondylalgia

Nominated PICIHR2011Planning Grants - PA: Community-based Primary Healthcare

Principal investigators: Scott, Alexander

Keywords: Lateral Epicondylalgia; Occupational Injuries

$14,322

Mechanisms of tenocyte mechanotransduction

Principal investigatorNSERC2011Discovery Grants Program - Individual

Principal investigators: Scott, Alexander

$140,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Physical Therapy
Centre for Hip Health and Mobility
Cellular and Physiological Sciences
Other

Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Michael Hunt

Physical Therapy

1 shared papers, latest 2024

Michael Underhill

Cellular and Physiological Sciences

1 shared papers, latest 2011

David Wilson

Centre for Hip Health and Mobility

1 shared papers, latest 2017

Brian Cairns

Faculty

1 shared papers, latest 2017

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2019

Subject: Prospective PhD student: Tendinopathy Dear Professor Scott, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Understanding the impact of Achilles lipid content on tendon mechanical parameters: a cross-sectional study of people with familial hypercholesterolemia and healthy controls." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Tendon impairment in people with familal hypercholesterolemia: clinical and laboratory studies" (2019), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Alexander Scott

Research

Latest papers

Latest funding

Understanding the impact of Achilles lipid content on tendon mechanical parameters: a cross-sectional study of people with familial hypercholesterolemia and healthy controls.

Osteoarthritic Tibiofemoral Joint Contact Characteristics During Weightbearing With Arch-Supported and Standalone Lateral Wedge Insoles.

In vitro collagen biomarkers in mechanically stimulated human tendon cells: a systematic review.

Clinically-accessible and laboratory-derived predictors of biomechanical response to standalone and supported lateral wedge insoles in people with knee osteoarthritis.

The impact of mild hypercholesterolemia on injury repair in the rat patellar tendon.

Mild hypercholesterolemia impacts achilles sub-tendon mechanical properties in young rats.

Case Studies in Physiology: Adaptation of load-bearing tendons during pregnancy.

Multiple Functional Brain Networks Related to Pain Perception Revealed by fMRI.

The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study.

Transverse tendon stiffness is reduced in people with Achilles tendinopathy: A cross-sectional study.

Tendon impairment in people with familal hypercholesterolemia: clinical and laboratory studies

Tendon cell mechanotransduction

Tendon physiology and biomechanics

Tendon physiology and biomechanics

The influence of hypercholesterolemia on characteristics of tendon health

Impact of oxidized LDL on mechanically induced collagen synthesis: an in vitro study of human tendon fibroblasts

Role of mast cells in tendinopathy

Role of mast cells in Achilles tendinopathy

Feasibility of a randomized controlled trial of ketotifen for lateral epicondylalgia

Mechanisms of tenocyte mechanotransduction

Frequent collaborators

Michael Hunt

Michael Underhill

David Wilson

Christopher West

Brian Cairns