This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses and email address may be missing. Find their university profile.
Research
Latest papers
Conditional knockout of membrane-type I matrix metalloproteinase in smooth muscle cells of adult mice alleviates atherosclerosis without affecting basic cardiovascular function.
Clinical and translational medicine · 2026
Cardiovascular risk and subclinical atherosclerosis in first-degree relatives of patients with premature cardiovascular disease.
American journal of preventive cardiology · 2024
High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture.
Molecular neurodegeneration · 2017
Latest funding
- $906,525
Arterial smooth muscle cell lysosomal acid lipase as a novel target for atherosclerosis treatment and prevention
CIHR · 2024 · Nominated PI
- $105,000
Understanding macrophage-smooth muscle cell interactions in foam cell development in atherosclerosis
CIHR · 2023 · Supervisor
- $674,605
The importance of smooth muscle foam cells in atherosclerosis development and treatment
CIHR · 2021 · Nominated PI
6 publications.
Conditional knockout of membrane-type I matrix metalloproteinase in smooth muscle cells of adult mice alleviates atherosclerosis without affecting basic cardiovascular function.
Jarad S, Gu HM, Huang D, Amadi P, Gill G, Spaans F, Chatha A, Yousef A, Graton ME, Patel R, Seubert JM, Wang Y, Francis G, Xia XD, Davidge ST, Zhang DW
Cardiovascular risk and subclinical atherosclerosis in first-degree relatives of patients with premature cardiovascular disease.
Vikulova DN, Pinheiro-Muller D, Francis G, Halperin F, Sedlak T, Walley K, Fordyce C, Mancini GJ, Pimstone SN, Brunham LR
High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture.
Robert J, Button EB, Stukas S, Boyce GK, Gibbs E, Cowan CM, Gilmour M, Cheng WH, Soo SK, Yuen B, Bahrabadi A, Kang K, Kulic I, Francis G, Cashman N, Wellington CL
Surfactant protein-D deficiency suppresses systemic inflammation and reduces atherosclerosis in ApoE knockout mice.
Hirano Y, Choi A, Tsuruta M, Jaw JE, Oh Y, Ngan D, Moritani K, Chen YR, Tam S, Li Y, Vasilescu DM, Hogg JC, Francis G, Bernatchez P, Man SP, Sin DD
Early atherosclerosis detection in asymptomatic patients: a comparison of carotid ultrasound, coronary artery calcium score, and coronary computed tomography angiography.
Schroeder B, Francis G, Leipsic J, Heilbron B, John Mancini GB, Taylor CM
Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study.
Devonshire V, Havrdova E, Radue EW, O'Connor P, Zhang-Auberson L, Agoropoulou C, Häring DA, Francis G, Kappos L, FREEDOMS study group
Arterial smooth muscle cell lysosomal acid lipase as a novel target for atherosclerosis treatment and prevention
Principal investigators: Francis, Gordon A
Keywords: Atherosclerosis; Cholesterol; Coronary Heart Disease; Lipid Metabolism; Lysosomal Acid Lipase; Lysosomes; Macrophage; Smooth Muscle
Understanding macrophage-smooth muscle cell interactions in foam cell development in atherosclerosis
Principal investigators: Xiang, Pinhao
Keywords: Atherosclerosis; Cardiovascular Diseases; Cytokine Crosstalk; Foam Cell Development; Lipoproteins Transport; Macrophages; Smooth Muscle Cells
The importance of smooth muscle foam cells in atherosclerosis development and treatment
Principal investigators: Francis, Gordon A
Keywords: Atherosclerosis; Cholesterol; Coronary Heart Disease; Lipid Metabolism; Macrophage; Smooth Muscle
Molecular and cellular phenotyping of smooth muscle cell foam cells for the prevention of atherosclerosis
Principal investigators: Blanchard, Valentin
Keywords: Atherosclerosis; Cardiovascular Disease; Cholesterol; Foam Cells; Lipoproteins; Smooth Muscle Cells
Homozygous Familial Hypercholesterolemia (HoFH) in Canada
Principal investigators: Genest, Jacques Jr.; Bernard, Sophie
Keywords: Cholesterol; Familial Hypercholesterolemia; Genetics; Homozygous Familial Hypercholesterolemia; Low Density Lipoprotein Receptor; Low Density Lipoproteins
Relative deficiency of lysosomal acid lipase in arterial smooth muscle cells as a novel target for atherosclerosis treatment and prevention
Principal investigators: Francis, Gordon A
Keywords: Abca1; Atherosclerosis; Cholesterol; Low Density Lipoprotein; Lysosomal Acid Lipase; Smooth Muscle Cells
The critical role of plasma cholesterol in the pathogenesis of muscular dystrophy
Principal investigators: Bernatchez, Pascal N
Keywords: Cholesterol; Duchenne Muscular Dystrophy; Limb-Girdle Muscular Dystrophy; Lipoproteins
The unrecognized importance of smooth muscle foam cells in atherosclerosis development and treatment
Principal investigators: Francis, Gordon A
Keywords: Abca1; Atherosclerosis; Cholesterol; Cholesterol Transport; Coronary Arteries; Lipoproteins; Smooth Muscle Cells
Cellular lipid efflux and HDL formation
Principal investigators: Francis, Gordon A
Keywords: Apolipoprotein Mimetics; Apolipoproteins; Artery Wall; Atherosclerosis; Cell Biology; Cholesterol
The role of lyososomal cholesterol in the regulation of ABCA1 expression and HDL formation
Principal investigators: Francis, Gordon A
Keywords: Abca1; Atherosclerosis; Cholesterol; Coronary Heart Disease; Hdl; Intracellular Cholesterol Transport
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Medicine
- UBC James Hogg Research Centre
- Anesthesiology, Pharmacology and Therapeutics
- Pathology and Laboratory Medicine
- Other
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Ying Wang
Pathology and Laboratory Medicine
1 shared papers, latest 2026
Christopher Fordyce
Faculty
1 shared papers, latest 2024
Keith Walley
Medicine
1 shared papers, latest 2024
Neil Cashman
UBC James Hogg Research Centre
1 shared papers, latest 2017
Pascal Bernatchez
Anesthesiology, Pharmacology and Therapeutics
1 shared papers, latest 2017
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