Faculty profile
Pascal Bernatchez
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Latest papers
A Retrospective Analysis of Human Angiotensin II Receptor Blockers (ARB) Pharmacokinetics, Dosages and Cmax Values for the Experimental Modelling of Pleiotropic and Supratherapeutic Activities.
Basic & clinical pharmacology & toxicology · 2026 · senior author
Exploring pulse wave velocity as a vascular hemodynamic stress marker: more than just arterial stiffening?
American journal of physiology. Heart and circulatory physiology · 2026 · senior author
High-Density Lipoprotein-Associated Cholesterol Abnormalities in a Clinical Outcomes Study of Dysferlin-Deficient Limb-Girdle Muscular Dystrophy Type R2.
Journal of cachexia, sarcopenia and muscle · 2025
Latest funding
- $914,175
Activation of the chronic endothelial function reserve for the prevention and regression of aortopathies.
CIHR · 2024 · Nominated PI
- $1,500
Early endothelial function activation by angiotensin II receptor blockers prevents vascular damage in a model of diabetes
CIHR · 2023 · Supervisor
- $105,000
The Potency and Efficacy of Losartan and its Metabolites in the Treatment of Pulmonary Hypertension
CIHR · 2022 · Supervisor
48 publications.
A Retrospective Analysis of Human Angiotensin II Receptor Blockers (ARB) Pharmacokinetics, Dosages and Cmax Values for the Experimental Modelling of Pleiotropic and Supratherapeutic Activities.
Evans A, Bernatchez P
Exploring pulse wave velocity as a vascular hemodynamic stress marker: more than just arterial stiffening?
Yuen C, Devlin AM, Bernatchez P
High-Density Lipoprotein-Associated Cholesterol Abnormalities in a Clinical Outcomes Study of Dysferlin-Deficient Limb-Girdle Muscular Dystrophy Type R2.
White Z, Rufibach L, Dressman HG, Hilsden H, Cox D, Spuler S, Day JW, Jones KJ, Bharucha-Goebel DX, Salort-Campana E, Pestronk A, Walter MC, Paradas C, Stojkovic T, Mori-Yoshimura M, Bravver E, Diaz-Manera J, Pegoraro E, Mendell JR, Jain COS Consortium, Straub V, Bernatchez P
Comparative lipidomic and metabolomic profiling of mdx and severe mdx-apolipoprotein e-null mice.
Khattri RB, Batra A, White Z, Hammers D, Ryan TE, Barton ER, Bernatchez P, Walter GA
Losartan and metabolite EXP3179 activate endothelial function without lowering blood pressure in AT2 receptor KO mice.
Sauge E, White Z, Lizotte F, Yuen C, Atmuri NDP, Ciufolini MA, Geraldes P, Bernatchez P
Apolipoprotein E knockout, but not cholesteryl ester transfer protein (CETP)-associated high-density lipoprotein cholesterol (HDL-C) lowering, exacerbates muscle wasting in dysferlin-null mice.
Sun Z, White Z, Theret M, Bernatchez P
Scaffolds and the scaffolding domain: an alternative paradigm for caveolin-1 signaling.
Lim JE, Bernatchez P, Nabi IR
Magnetic resonance quantification of skeletal muscle lipid infiltration in a humanized mouse model of Duchenne muscular dystrophy.
Khattri RB, Batra A, Matheny M, Hart C, Henley-Beasley SC, Hammers D, Zeng H, White Z, Ryan TE, Barton E, Bernatchez P, Walter GA
Heterogenous improvements in endothelial function by sub-blood pressure lowering doses of ARBs result in major anti-aortic root remodeling effects.
Tehrani AY, Zhao R, Donen G, Bernatchez P
Dyslipidemia in Muscular Dystrophy: A Systematic Review and Meta-Analysis.
Sun Z, Wang X, White Z, Dormuth C, Morales F, Bernatchez P
Activation of the chronic endothelial function reserve for the prevention and regression of aortopathies.
Principal investigators: Bernatchez, Pascal N
Keywords: Aneurysm; Angiotensin; Aorta; Endothelium; Losartan; Marfan Syndrome; Nitric Oxide
Early endothelial function activation by angiotensin II receptor blockers prevents vascular damage in a model of diabetes
Principal investigators: Yuen, Christopher
Keywords: Type 1 Diabetes (T1d)
The Potency and Efficacy of Losartan and its Metabolites in the Treatment of Pulmonary Hypertension
Principal investigators: Evans, Alexandria
Keywords: Endothelium; Losartan; Losartan Metabolites; Pulmonary Hypertension
Natural and accelerated aging of the eNOS-caveolin-1 system
Principal investigators: Bernatchez, Pascal
Targeting cancer-associated fibroblasts and tumour hypoxia with angiotensin II receptor blockers
Principal investigators: Bennewith, Kevin L
Keywords: Angiotensin Ii Receptor Blockers; Cancer-Associated Fibroblasts; Flow Cytometry; Hypoxia Markers; Immunofluorescence Microscopy; Renin-Angiotensin System; Solid Tumour Microenvironment; Telmisartan; Tumour Hypoxia; Tumour Perfusion
Correcting early vascular dysfunction to improve cardiovascular outcomes in type 1 diabetes
Principal investigators: Devlin, Angela M; Bernatchez, Pascal N; Panagiotopoulos, Constadina
Keywords: Aortic Stiffness; Blood Pressure; Children; Endothelial Cells; Type 1 Diabetes
Pleiotropic activation of endothelial function by angiotensin II receptor blockers is crucial to their protective anti-vascular remodeling effects
Principal investigators: Tehrani, Arash Y
Keywords: Ics Travel Awards
The role of endothelial function in the pathogenesis and management of Marfan syndrome-associated aortic disease
Principal investigators: Bernatchez, Pascal N; Esfandiarei, Mitra; Harris, Kevin; Potts, James E; Sandor, George G; Van Breemen, Cornelis C
Keywords: Aorta; Endothelial Function; Endothelium; Losartan; Marfan
Heterogeneity of Angiotensin II Receptor Blockers in the inhibition of Marfan-associated Aortic Root Dilation Independent of Blood Pressure Effects
Principal investigators: Tehrani, Arash Y
Keywords: Ics Travel Awards
The critical role of plasma cholesterol in the pathogenesis of muscular dystrophy
Principal investigators: Bernatchez, Pascal N
Keywords: Cholesterol; Duchenne Muscular Dystrophy; Limb-Girdle Muscular Dystrophy; Lipoproteins
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Mitra Esfandiarei and Cornelis Van Breemen: 11 shared papers
- Pascal Bernatchez and Mitra Esfandiarei: 6 shared papers
- Honglin Luo and Mitra Esfandiarei: 4 shared papers
- Honglin Luo and Cornelis Van Breemen: 4 shared papers
- Pascal Bernatchez and Cornelis Van Breemen: 4 shared papers
- Jeremy Hirota and Tillie-Louise Hackett: 3 shared papers
- Pascal Bernatchez and Fabio Rossi: 3 shared papers
- Jeremy Hirota and Honglin Luo: 2 shared papers
- Pascal Bernatchez and Tillie-Louise Hackett: 2 shared papers
- Jeremy Hirota and Pascal Bernatchez: 1 shared paper
- Bernardo Trigatti and Pascal Bernatchez: 1 shared paper
- Bernardo Trigatti and Catherine Martel: 1 shared paper
- Chun Seow and Pascal Bernatchez: 1 shared paper
- Chun Seow and Fabio Rossi: 1 shared paper
- Honglin Luo and Pascal Bernatchez: 1 shared paper
- Honglin Luo and Tillie-Louise Hackett: 1 shared paper
- Honglin Luo and Ismail Laher: 1 shared paper
- Pascal Bernatchez and Pedro Geraldes: 1 shared paper
- Pascal Bernatchez and Ismail Laher: 1 shared paper
- Pascal Bernatchez and Catherine Martel: 1 shared paper
- Pascal Bernatchez and Gordon Francis: 1 shared paper
- Pascal Bernatchez and Colin Dormuth: 1 shared paper
- Pascal Bernatchez and John Boyd: 1 shared paper
- Pascal Bernatchez and Constadina Panagiotopoulos: 1 shared paper
- Ismail Laher and Cornelis Van Breemen: 1 shared paper
- Fabio Rossi and Constadina Panagiotopoulos: 1 shared paper
- Anesthesiology, Pharmacology and Therapeutics
- Medicine
- Pathology and Laboratory Medicine
- Pediatrics
- Biomedical Engineering
- Biochemistry & Biomedical Sciences
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Mitra Esfandiarei
Anesthesiology, Pharmacology and Therapeutics
6 shared papers, latest 2022
Cornelis Van Breemen
Anesthesiology, Pharmacology and Therapeutics
4 shared papers, latest 2021
Fabio Rossi
Biomedical Engineering
3 shared papers, latest 2022
Tillie-Louise Hackett
Anesthesiology, Pharmacology and Therapeutics
2 shared papers, latest 2019
Colin Dormuth
Anesthesiology, Pharmacology and Therapeutics
1 shared papers, latest 2023
John Boyd
Medicine
1 shared papers, latest 2022
Pedro Geraldes
Medicine
1 shared papers, latest 2024
Constadina Panagiotopoulos
Pediatrics
1 shared papers, latest 2020
Ismail Laher
Pediatrics
1 shared papers, latest 2020
Catherine Martel
Medicine
1 shared papers, latest 2019
Gordon Francis
Medicine
1 shared papers, latest 2017
Jeremy Hirota
Medicine
1 shared papers, latest 2018
Bernardo Trigatti
Biochemistry & Biomedical Sciences
1 shared papers, latest 2019
Chun Seow
Pathology and Laboratory Medicine
1 shared papers, latest 2018
Honglin Luo
Pathology and Laboratory Medicine
1 shared papers, latest 2015
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