Faculty profile

Jayachandran Kizhakkedathu

ResearcherPathology and Laboratory MedicineUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses and email address may be missing. Find their university profile.

Jayachandran Kizhakkedathu

Researcher

Pathology and Laboratory Medicine

Health Sciences

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
1 publication in the last five years, latest in 2024.
Principal investigator on 30 research grants (24 CIHR, 6 NSERC), most recently in 2025.
Supervised 3 trainees who won CIHR awards, most recently in 2026.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Hyperbranched Polyglycerol Biomaterials Transplantation Polymeric Biomaterials End-Stage Renal Disease Peritoneal Dialysis Immunomodulation Glycosidases

Latest papers

Identification of the proteolytic signature in CVB3-infected cells.
Journal of virology · 2024
N-Terminomics/TAILS Profiling of Proteases and Their Substrates in Ulcerative Colitis.
ACS chemical biology · 2019
Deep Profiling of the Cleavage Specificity and Human Substrates of Snake Venom Metalloprotease HF3 by Proteomic Identification of Cleavage Site Specificity (PICS) Using Proteome Derived Peptide Libraries and Terminal Amine Isotopic Labeling of Substrates (TAILS) N-Terminomics.
Journal of proteome research · 2019

All 8 publications

Latest funding

Rapid Rebuilding of the Functional Endothelial Glycocalyx to Prevent Microvascular Damage in Severe
CIHR · 2026 · Supervisor
$6,000
CBS/CSPS-2026 Conference: Next Generation Biomaterials and Pharmaceutical Technologies for All
CIHR · 2025 · Nominated PI
$20,000
Transfusion Without Blood Typing: Enzymatic Glycoengineering Towards 'True' Universal Blood
CIHR · 2024 · Nominated PI
$1,013,626

All 61 grants and awards

8 publications.

Identification of the proteolytic signature in CVB3-infected cells.

Vlok M, Solis N, Sadasivan J, Mohamud Y, Warsaba R, Kizhakkedathu J, Luo H, Overall CM, Jan E

Journal of virology2024

DOI: 10.1128/jvi.00498-24 PMID: 38953667

N-Terminomics/TAILS Profiling of Proteases and Their Substrates in Ulcerative Colitis.

Gordon MH, Anowai A, Young D, Das N, Campden RI, Sekhon H, Myers Z, Mainoli B, Chopra S, Thuy-Boun PS, Kizhakkedathu J, Bindra G, Jijon HB, Heitman S, Yates R, Wolan DW, Edgington-Mitchell LE, MacNaughton WK, Dufour A

ACS chemical biology2019

DOI: 10.1021/acschembio.9b00608 PMID: 31393699

Deep Profiling of the Cleavage Specificity and Human Substrates of Snake Venom Metalloprotease HF3 by Proteomic Identification of Cleavage Site Specificity (PICS) Using Proteome Derived Peptide Libraries and Terminal Amine Isotopic Labeling of Substrates (TAILS) N-Terminomics.

Zelanis A, Oliveira AK, Prudova A, Huesgen PF, Tashima AK, Kizhakkedathu J, Overall CM, Serrano SMT

Journal of proteome research2019

DOI: 10.1021/acs.jproteome.9b00325 PMID: 31337208

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.

Quancard J, Klein T, Fung SY, Renatus M, Hughes N, Israël L, Priatel JJ, Kang S, Blank MA, Viner RI, Blank J, Schlapbach A, Erbel P, Kizhakkedathu J, Villard F, Hersperger R, Turvey SE, Eder J, Bornancin F, Overall CM

Nature chemical biology2019

DOI: 10.1038/s41589-018-0222-1 PMID: 30692685

Simplified high yield TAILS terminomics using a new HPG-ALD 800K-2000 polymer with precipitation.

Solis N, Parambath A, Abbina S, Kizhakkedathu J, Overall CM

Methods in enzymology2019

DOI: 10.1016/bs.mie.2019.07.030 PMID: 31606086

Global Profiling of Proteolysis from the Mitochondrial Amino Terminome during Early Intrinsic Apoptosis Prior to Caspase-3 Activation.

Marshall NC, Klein T, Thejoe M, von Krosigk N, Kizhakkedathu J, Finlay BB, Overall CM

Journal of proteome research2018

DOI: 10.1021/acs.jproteome.8b00675 PMID: 30371095

N-Terminomics TAILS Identifies Host Cell Substrates of Poliovirus and Coxsackievirus B3 3C Proteinases That Modulate Virus Infection.

Jagdeo JM, Dufour A, Klein T, Solis N, Kleifeld O, Kizhakkedathu J, Luo H, Overall CM, Jan E

Journal of virology2018

DOI: 10.1128/jvi.02211-17 PMID: 29437971

Reversible hemostatic properties of sulfabetaine/quaternary ammonium modified hyperbranched polyglycerol.

Wen J, Weinhart M, Lai B, Kizhakkedathu J, Brooks DE

Biomaterials2016

DOI: 10.1016/j.biomaterials.2016.01.067 PMID: 26885776

Rapid Rebuilding of the Functional Endothelial Glycocalyx to Prevent Microvascular Damage in Severe

SupervisorCIHR2026Undergraduate Student Research Awards (USRA)

Principal investigators: Attafuah, Ideog

Keywords: Disease; Inflammation; Sepsis

$6,000

CBS/CSPS-2026 Conference: Next Generation Biomaterials and Pharmaceutical Technologies for All

Nominated PICIHR2025Planning and Dissemination Grant - Institute Community Support

Principal investigators: Kizhakkedathu, Jayachandran N

Keywords: Anti-Infective Biomaterials; Canadan Pharmaceutical Sciences Annual Meeting; Canadian Biomaterials Society Annual Meeting; Conference; Dissemination; Drug Delivery; Immunomodulation; Inflammation; Knowledge Translation; Therapeutics

$20,000

Transfusion Without Blood Typing: Enzymatic Glycoengineering Towards 'True' Universal Blood

Nominated PICIHR2024Project Grant

Principal investigators: Kizhakkedathu, Jayachandran N; Withers, Stephen G

Keywords: Blood Transfusion; Cell Surface Modification; Enzymatic Glycoengineering; Glycocalyx Extension; Glycosidases; Immune Matching; Immune Protection; Metagenomics; Polysialylation; Universal Blood

$1,013,626

Self-sterilizing Blood Storage Devices for Safer Transfusion of Platelets and Whole Blood

Nominated PICIHR2024Project Grant

Principal investigators: Kizhakkedathu, Jayachandran N

Keywords: Antimicrobial Peptides; Biomaterials; Blood Compatible Materials; Blood Storage Devices; Blood Transfusion; Fresh Whole Blood Transfusion; High Throughput Screening; Infection Resistant Surfaces; Medical Devices; Platelet Transfusion

$868,275

Celebrating World Thrombosis Day: Raising Awareness to Save Lives

Co-investigatorCIHR2023CIHR Café Scientifique Program - Institute of Circulatory and Respiratory Health

Principal investigators: Kim, Hugh

Keywords: Cardiovascular Disease; Myocardial Infarction; Stroke; Thrombosis; Venous Thromboembolism

$6,000

Localized immuno-cloaking organ engineering approach to prevent transplant rejection without immunosuppressants

Nominated PICIHR2022Project Grant

Principal investigators: Kizhakkedathu, Jayachandran N

Keywords: Immune-Cloaking; Immune-Mediated Rejection; Immunoengineering; Immunosupressing Polymers; Kidney Transplantation; Localized Immunotherapy; Lung Transplantation; Organ Engineering; Organ Protection; Transplantation

$803,250

Canada Research Chair - Tier 1

Nominated PICIHR2021Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Kizhakkedathu, Jayachandran N

Keywords: Crc

$1,400,000

Novel Infection Resistant Coating in an Era of Drug Resistant Bacteria for the Treatment and Prevention of Medical Device Infection

Nominated PICIHR2020Project Grant

Principal investigators: Kizhakkedathu, Jayachandran N; Lange, Dirk

Keywords: Antibiotic Resistance; Biocompatible Polymer Coatings; Catheter-Associated Urinary Tract Infection (Cauti); Drug Release Coatings; Infection Resistant Coatings; Medical Device Associated Infection; Polymeric Biomaterials; Universal Coating; Urinary Catheters; Uropathogens

$520,199

Novel antifouling and antibiofilm coating technologies for membrane applications: A market research study

Principal investigatorNSERC2020Idea to Innovation

Principal investigators: Kizhakkedathu, Jayachandran

$15,000

Reduce spreading of Covid-19 by using antiviral coatings in senior care homes and hospitals_x000d_ _x000d_ _x000d_

Co-investigatorNSERC2020Alliance Grants

Principal investigators: Wang, Rizhi

$50,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Jayachandran Kizhakkedathu

Research

Latest papers

Latest funding

Identification of the proteolytic signature in CVB3-infected cells.

N-Terminomics/TAILS Profiling of Proteases and Their Substrates in Ulcerative Colitis.

Deep Profiling of the Cleavage Specificity and Human Substrates of Snake Venom Metalloprotease HF3 by Proteomic Identification of Cleavage Site Specificity (PICS) Using Proteome Derived Peptide Libraries and Terminal Amine Isotopic Labeling of Substrates (TAILS) N-Terminomics.

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.

Simplified high yield TAILS terminomics using a new HPG-ALD 800K-2000 polymer with precipitation.

Global Profiling of Proteolysis from the Mitochondrial Amino Terminome during Early Intrinsic Apoptosis Prior to Caspase-3 Activation.

N-Terminomics TAILS Identifies Host Cell Substrates of Poliovirus and Coxsackievirus B3 3C Proteinases That Modulate Virus Infection.

Reversible hemostatic properties of sulfabetaine/quaternary ammonium modified hyperbranched polyglycerol.

Rapid Rebuilding of the Functional Endothelial Glycocalyx to Prevent Microvascular Damage in Severe

CBS/CSPS-2026 Conference: Next Generation Biomaterials and Pharmaceutical Technologies for All

Transfusion Without Blood Typing: Enzymatic Glycoengineering Towards 'True' Universal Blood

Self-sterilizing Blood Storage Devices for Safer Transfusion of Platelets and Whole Blood

Celebrating World Thrombosis Day: Raising Awareness to Save Lives

Localized immuno-cloaking organ engineering approach to prevent transplant rejection without immunosuppressants

Canada Research Chair - Tier 1

Novel Infection Resistant Coating in an Era of Drug Resistant Bacteria for the Treatment and Prevention of Medical Device Infection

Novel antifouling and antibiofilm coating technologies for membrane applications: A market research study

Reduce spreading of Covid-19 by using antiviral coatings in senior care homes and hospitals_x000d_ _x000d_ _x000d_

Frequent collaborators

Honglin Luo

Eric Jan

Robin Yates

Antoine Dufour

Steven Heitman

Yasir Mohamud