Honglin Luo, University of British Columbia

Research

Viral Myocarditis Autophagy Enterovirus Coxsackievirus Antiviral Drugs Cgas-Sting Pathway Inflammation Innate Immunity

Latest papers

Therapeutic Target Mapping to Advance Drug Repurposing for Cardiovascular Disease: A Perspective from an Explanted Heart Biobank.
Journal of personalized medicine · 2026
Genetic factors contributing to viral myocarditis.
Microbiology and molecular biology reviews : MMBR · 2026 · senior author
Developing a Personalized Cancer Nanovaccine Using Coxsackievirus-Reprogrammed Cancer Cell Membranes for Enhanced Anti-Tumor Immunity.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025 · senior author

All 100 publications

Latest funding

Unraveling enterovirus-induced autophagy disruption for novel therapeutic strategies in viral myocarditis
CIHR · 2025 · Nominated PI
$1,009,800
Lipid nanoparticle-based delivery of a genetically engineered coxsackievirus B3 (CVB3) as a therapeutic cancer vaccine for lung cancer therapy
CIHR · 2025 · Supervisor
$120,000
A platform for developing mutation-resistant vaccines and antibodies for future viral variants, using SARS-CoV-2 as a model
CIHR · 2023 · Co-investigator

All 17 grants and awards

100 publications.

01

Therapeutic Target Mapping to Advance Drug Repurposing for Cardiovascular Disease: A Perspective from an Explanted Heart Biobank.

Ng C, Singhera GK, Chang EC, Samra A, Adolphs KA, Phillips EH, Bashir J, Laksman Z, Luo H, Francis GA, Lai C, Wang Y

Journal of personalized medicine2026

DOI: 10.3390/jpm16080416 PMID: 42645910

02

Genetic factors contributing to viral myocarditis.

Wang Z, Mohamud Y, Luo H

Microbiology and molecular biology reviews : MMBR2026Senior author

DOI: 10.1128/mmbr.00357-25 PMID: 42007711

03

Developing a Personalized Cancer Nanovaccine Using Coxsackievirus-Reprogrammed Cancer Cell Membranes for Enhanced Anti-Tumor Immunity.

Bahreyni A, Mohamud Y, Singh A, Banijamali RS, Tang J, Zhang J, Luo H

Advanced science (Weinheim, Baden-Wurttemberg, Germany)2025Senior author

DOI: 10.1002/advs.202506791 PMID: 40729737

04

Cellular protein quality control in viral myocarditis: molecular mechanisms and therapeutic implication.

Mohamud Y, Lin JC, Hwang SW, Bahreyni A, Luo H

Microbiology and molecular biology reviews : MMBR2025Senior author

DOI: 10.1128/mmbr.00177-25 PMID: 40833122

05

Mitochondrial injury and complement dysregulation are drivers of pathological inflammation in viral myocarditis.

Mohamud Y, Bahreyni A, Hwang SW, Lin JC, Wang ZC, Zhang J, Luo H

Journal of virology2025Senior author

DOI: 10.1128/jvi.01804-24 PMID: 39846741

06

Interleukin-1α inhibits transforming growth factor-β1 and β2-induced extracellular matrix production, remodeling and signaling in human lung fibroblasts: Master regulator in lung mucosal repair

Usman K, Fouadi M, Nwozor KO, Aminazadeh F, Nair P, Luo H, Sin DD, Osei ET, Hackett T-L

Matrix Biology20249 citations

DOI: 10.1016/j.matbio.2024.06.007

07

Oncolytic virus-based combination therapy in breast cancer.

Bahreyni A, Mohamud Y, Luo H

Cancer letters2024Senior author

DOI: 10.1016/j.canlet.2024.216634 PMID: 38309616

08

Synergistic Viro-chemoimmunotherapy in Breast Cancer Enabled by Bioengineered Immunostimulatory Exosomes and Dual-Targeted Coxsackievirus B3.

Bahreyni A, Mohamud Y, Ashraf Nouhegar S, Zhang J, Luo H

ACS nano2024Senior author

DOI: 10.1021/acsnano.3c09491 PMID: 38278522

09

Activation of cGAS-STING suppresses coxsackievirus replication via interferon-dependent signaling.

Mohamud Y, Fu C, Fan YM, Zhang YL, Lin JFC, Hwang SW, Wang ZC, Luo H

Antiviral research2024Senior author

DOI: 10.1016/j.antiviral.2024.105811 PMID: 38242503

10

Identification of the proteolytic signature in CVB3-infected cells.

Vlok M, Solis N, Sadasivan J, Mohamud Y, Warsaba R, Kizhakkedathu J, Luo H, Overall CM, Jan E

Journal of virology2024

DOI: 10.1128/jvi.00498-24 PMID: 38953667

Unraveling enterovirus-induced autophagy disruption for novel therapeutic strategies in viral myocarditis

Nominated PICIHR2025Project Grant

Principal investigators: Luo, Honglin

Keywords: Antiviral Drugs; Autophagy; Viral Myocarditis

$1,009,800

Lipid nanoparticle-based delivery of a genetically engineered coxsackievirus B3 (CVB3) as a therapeutic cancer vaccine for lung cancer therapy

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Karimi Qezeljeh Meydan, Hesam

Keywords: Cancer Research; Lipid Nanoparticle; Lung Cancer Therapy; Oncolytic Viruses; Vaccine Research

$120,000

A platform for developing mutation-resistant vaccines and antibodies for future viral variants, using SARS-CoV-2 as a model

Co-investigatorCIHR2023Project Gr. PA: Res. on Prevention/Response to Covid-19/Similar Future Pandemics

Principal investigators: Plotkin, Steven S

Keywords: Deep Mutational Scanning; Genomics; Mutational Escape; Pandemic Preparedness; Pseudotyped Viruses; Rationally Designed Antibodies; Rationally Designed Vaccines; Sars-Cov-2 Spike Protein; Structural Biology; Viral Evolution

Elucidating the Intricate Interplay between Mitochondria, Innate Immunity, and Viral Pathogenesis in Heart Failure

SupervisorCIHR2023CIHR REDI Early Career Transition Award - Infectious Disease and Immune System

Principal investigators: Mohamud, Yasir

Keywords: Virology

$270,000

Innate immune mechanisms of viral myocarditis: Role of the cytosolic DNA-sensing pathway

Nominated PICIHR2022Project Grant

Principal investigators: Luo, Honglin

Keywords: Cgas-Sting Pathway; Enterovirus; Inflammation; Innate Immunity; Viral Myocarditis

$910,350

Autophagy mechanism of coronaviral infection: Lessons from enteroviruses

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Luo, Honglin

$120,000

Repurposing an FDA-approved anti-gout drug for the treatment of COVID-19

Nominated PICIHR2020Operating Grant: COVID-19 - Project Grant

Principal investigators: Luo, Honglin

Keywords: Anti-Gout Drug; Anti-Inflammation; Anti-Viral; Covid-19; Probenecid; Remdesivir; Rna Viruses; Sars-Cov-2

$562,275

Enterovirus subversion of the autophagy pathway

Nominated PICIHR2020Project Grant

Principal investigators: Luo, Honglin

Keywords: Autophagy; Cleavage; Coxsackievirus; Enterovirus; Protease; Replication

$734,400

Enteroviral Infection in the Development of Amyotrophic Lateral Sclerosis

SupervisorCIHR2019Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Xue, Yuan Chao

Keywords: Animal Models; Neurodegeneration; Virus Infection

$105,000

Role of enteroviral infection in amyotrophic lateral sclerosis

Nominated PICIHR2018Project Grant

Principal investigators: Luo, Honglin; Cashman, Neil R

Keywords: Amyotrophic Lateral Sclerosis; Autophagy; Enterovirus; Neurodegeneration; Prion; Protein Misfolding; Sod1; Tdp-43

$1,002,150

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Honglin Luo and Yasir Mohamud: 40 shared papers
Mitra Esfandiarei and Cornelis Van Breemen: 11 shared papers
Honglin Luo and Eric Jan: 9 shared papers
Decheng Yang and Bruce McManus: 6 shared papers
Honglin Luo and Bruce McManus: 5 shared papers
Eric Jan and Yasir Mohamud: 5 shared papers
Honglin Luo and Decheng Yang: 4 shared papers
Honglin Luo and Mitra Esfandiarei: 4 shared papers
Honglin Luo and Cornelis Van Breemen: 4 shared papers
Jeremy Hirota and Honglin Luo: 2 shared papers
Jeremy Hirota and Eric Jan: 2 shared papers
Jeremy Hirota and Yasir Mohamud: 2 shared papers
Michael Sacher and Honglin Luo: 2 shared papers
Michael Sacher and Isabella Caniggia: 2 shared papers
Michael Sacher and Steve Jean: 2 shared papers
Michael Sacher and Khosrow Adeli: 2 shared papers
Michael Sacher and Xi-Long Zheng: 2 shared papers
Jayachandran Kizhakkedathu and Honglin Luo: 2 shared papers
Jayachandran Kizhakkedathu and Eric Jan: 2 shared papers
Honglin Luo and Isabella Caniggia: 2 shared papers
Honglin Luo and Steve Jean: 2 shared papers
Honglin Luo and Khosrow Adeli: 2 shared papers
Honglin Luo and Xi-Long Zheng: 2 shared papers
Isabella Caniggia and Steve Jean: 2 shared papers
Isabella Caniggia and Khosrow Adeli: 2 shared papers
Isabella Caniggia and Xi-Long Zheng: 2 shared papers
Bruce McManus and Mitra Esfandiarei: 2 shared papers
Andre Bedard and Michael Sacher: 1 shared paper
Andre Bedard and Craig McCormick: 1 shared paper
Andre Bedard and Honglin Luo: 1 shared paper
Andre Bedard and Eldad Zacksenhaus: 1 shared paper
Andre Bedard and Dusica Maysinger: 1 shared paper
Andre Bedard and Arnim Pause: 1 shared paper
Michael Sacher and Craig McCormick: 1 shared paper
Michael Sacher and Caigan Du: 1 shared paper
Michael Sacher and Eldad Zacksenhaus: 1 shared paper
Michael Sacher and Gary Sweeney: 1 shared paper
Michael Sacher and Dusica Maysinger: 1 shared paper
Michael Sacher and Arnim Pause: 1 shared paper
Michael Sacher and Ina Dobrinski: 1 shared paper
Craig McCormick and Honglin Luo: 1 shared paper
Craig McCormick and Eldad Zacksenhaus: 1 shared paper
Craig McCormick and Dusica Maysinger: 1 shared paper
Craig McCormick and Arnim Pause: 1 shared paper
Jayachandran Kizhakkedathu and Yasir Mohamud: 1 shared paper
Caigan Du and Honglin Luo: 1 shared paper
Caigan Du and Gary Sweeney: 1 shared paper
Caigan Du and Ina Dobrinski: 1 shared paper
Honglin Luo and Christopher Overall: 1 shared paper
Honglin Luo and Eldad Zacksenhaus: 1 shared paper
Honglin Luo and Gary Sweeney: 1 shared paper
Honglin Luo and Dusica Maysinger: 1 shared paper
Honglin Luo and Arnim Pause: 1 shared paper
Honglin Luo and Ali Bashashati: 1 shared paper
Honglin Luo and Gerald Pfeffer: 1 shared paper
Honglin Luo and Ina Dobrinski: 1 shared paper

Pathology and Laboratory Medicine
Biology
Biochemistry and Molecular Biology
Anesthesiology, Pharmacology and Therapeutics
Medicine
Lunenfeld-Tanenbaum Research Institute
Department of Laboratory Medicine and Pathobiology
Other

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Viral Myocarditis Dear Professor Luo, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Therapeutic Target Mapping to Advance Drug Repurposing for Cardiovascular Disease: A Perspective from an Explanted Heart Biobank." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Unraveling enterovirus-induced autophagy disruption for novel therapeutic strategies in viral myocarditis" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]