Faculty profile
Louis Lefebvre
Back to facultyThis profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses may be missing. Find their university profile.
Research
Latest papers
Genomic imprinting of the metabolic regulator gene Klf14 is regulated by a paternal sub-TAD anchored at Mest.
Genes & development · 2026 · senior author
Roles of endogenous retroviral elements in the establishment and maintenance of imprinted gene expression.
Frontiers in cell and developmental biology · 2024 · senior author
Parent-of-origin detection and chromosome-scale haplotyping using long-read DNA methylation sequencing and Strand-seq.
Cell genomics · 2023
Latest funding
- $47,000
Genomic imprinting at the Mest cluster: mechanism and function
NSERC · 2024 · Principal investigator
- $852,974
Parent-of-Origin-Aware Genomic Analysis in Hereditary Cancer
CIHR · 2022 · Co-investigator
- $956,250
Epigenetic regulation and function of species-specific imprinted genes: testing a new hypothesis for the evolution of imprinting
CIHR · 2019 · Nominated PI
26 publications.
Genomic imprinting of the metabolic regulator gene Klf14 is regulated by a paternal sub-TAD anchored at Mest.
Ha A, Hayashi N, Bogutz AB, Moindrot B, Gomez L, Harris J, Marcil A, Court F, Shindo M, Arnaud P, Drouin J, Forné T, Noordermeer D, Takada S, Nakabayashi K, Lefebvre L
Roles of endogenous retroviral elements in the establishment and maintenance of imprinted gene expression.
Fang S, Chang KW, Lefebvre L
Parent-of-origin detection and chromosome-scale haplotyping using long-read DNA methylation sequencing and Strand-seq.
Akbari V, Hanlon VCT, O'Neill K, Lefebvre L, Schrader KA, Lansdorp PM, Jones SJM
DNMT1 regulates the timing of DNA methylation by DNMT3 in an enzymatic activity-dependent manner in mouse embryonic stem cells.
Ito T, Kubiura-Ichimaru M, Murakami Y, Bogutz AB, Lefebvre L, Suetake I, Tajima S, Tada M
Cyclic DNA remethylation following active demethylation at euchromatic regions in mouse embryonic stem cells.
Kubiura-Ichimaru M, Ito T, Lefebvre L, Tada M
Precise coordination of cell-ECM adhesion is essential for efficient melanoblast migration during development.
Haage A, Wagner K, Deng W, Venkatesh B, Mitchell C, Goodwin K, Bogutz A, Lefebvre L, Van Raamsdonk CD, Tanentzapf G
Evolution of imprinting via lineage-specific insertion of retroviral promoters.
Bogutz AB, Brind'Amour J, Kobayashi H, Jensen KN, Nakabayashi K, Imai H, Lorincz MC, Lefebvre L
SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development.
Xu Q, Xiang Y, Wang Q, Wang L, Brind'Amour J, Bogutz AB, Zhang Y, Zhang B, Yu G, Xia W, Du Z, Huang C, Ma J, Zheng H, Li Y, Liu C, Walker CL, Jonasch E, Lefebvre L, Wu M, Lorincz MC, Li W, Li L, Xie W
Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo.
Haage A, Goodwin K, Whitewood A, Camp D, Bogutz A, Turner CT, Granville DJ, Lefebvre L, Plotnikov S, Goult BT, Tanentzapf G
Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome.
Tunster SJ, Van de Pette M, Creeth HDJ, Lefebvre L, John RM
Genomic imprinting at the Mest cluster: mechanism and function
Principal investigators: Lefebvre, Louis
Keywords: mouse developmental genetics; genomic imprinting; epigenetics; gene expression; alternative polyadenylation; chromatin conformation; mouse models
Parent-of-Origin-Aware Genomic Analysis in Hereditary Cancer
Principal investigators: Schrader, Kasmintan A; Jones, Steven; Lansdorp, Peter M
Keywords: Cancer Susceptibility; Cascade Genetic Testing; Hereditary Cancer; Long Read Sequencing; Parent-Of-Origin; Strand-Seq; Whole Genome Sequencing
Epigenetic regulation and function of species-specific imprinted genes: testing a new hypothesis for the evolution of imprinting
Principal investigators: Lefebvre, Louis
Keywords: Crispr-Cas9 Mutagenesis; Dna Methylation; Endogenous Retroviruses; Epigenetics; Genomic Imprinting; Human Trophoblast; Mouse Models; Oocyte; Trophoblast Stem Cells
Function and epigenetic regulation of the imprinted gene Ascl2
Principal investigators: Lefebvre, Louis
Defining the Roles of the Overgrowth Syndrome Genes NSD1, Setd2 and EZH2 in Shaping the Epigenome and Transcriptome in Early Embryonic Development
Principal investigators: Lorincz, Matthew C
Keywords: Chromatin; Ezh2; H3k36me3; Methylation; Nsd1; Overgrowth Syndromes; Polycomb; Setd2; Sotos Syndrome; Weaver Syndrome
Upgrade for fluorescence activated cell sorter
Principal investigators: Johnson, Pauline
Regulation of telomere position effect in the mouse
Principal investigators: Lefebvre, Louis
Developmental regulation of genomic imprinting in the mouse
Principal investigators: Lefebvre, Louis
Keywords: Epigenetics; Gene Expression; Genomic Imprinting; Germ Line; Mouse Developmental Genetics; Mouse Embryonic Stem Cells; Trophoblast
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Guy Tanentzapf and Louis Lefebvre: 2 shared papers
- Guy Tanentzapf and Sergey Plotnikov: 1 shared paper
- Peter Von Dadelszen and Louis Lefebvre: 1 shared paper
- Andras Nagy and Louis Lefebvre: 1 shared paper
- Louis Lefebvre and Sergey Plotnikov: 1 shared paper
- Department of Medical Genetics
- Department of Cellular and Physiological Sciences
- Lunenfeld-Tanenbaum Research Institute
- Obstetrics and Gynecology
- Department of Cell & Systems Biology
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Guy Tanentzapf
Department of Cellular and Physiological Sciences
2 shared papers, latest 2020
Sergey Plotnikov
Department of Cell & Systems Biology
1 shared papers, latest 2018
Peter Von Dadelszen
Obstetrics and Gynecology
1 shared papers, latest 2009
Andras Nagy
Lunenfeld-Tanenbaum Research Institute
1 shared papers, latest 2018
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