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Research
Latest papers
The role of mitochondrial apoptotic pathway in islet amyloid-induced β-cell death.
Molecular and cellular endocrinology · 2021 · senior author
Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling.
PloS one · 2018 · senior author
Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets.
Molecular metabolism · 2017 · senior author
Latest funding
- $627,000
Molecular mechanisms of islet amyloid mediated beta cell death
CIHR · 2012 · Nominated PI
- $376,515
Molecular mechanisms of islet amyloid mediated beta cell death.
CIHR · 2009 · Nominated PI
13 publications.
The role of mitochondrial apoptotic pathway in islet amyloid-induced β-cell death.
Wong HY, Hui Q, Hao Z, Warnock GL, Woo M, Luciani DS, Marzban L
Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling.
Zhang Y, Warnock GL, Ao Z, Park YJ, Safikhan N, Ghahary A, Marzban L
Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets.
Hui Q, Asadi A, Park YJ, Kieffer TJ, Ao Z, Warnock GL, Marzban L
Dual role of interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet transplantation.
Park YJ, Warnock GL, Ao Z, Safikhan N, Meloche M, Asadi A, Kieffer TJ, Marzban L
IDO-Expressing Fibroblasts Protect Islet Beta Cells From Immunological Attack and Reverse Hyperglycemia in Non-Obese Diabetic Mice.
Zhang Y, Jalili RB, Kilani RT, Elizei SS, Farrokhi A, Khosravi-Maharlooei M, Warnock GL, Ao Z, Marzban L, Ghahary A
New insights into the mechanisms of islet inflammation in type 2 diabetes.
Marzban L
The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets.
Park YJ, Woo M, Kieffer TJ, Hakem R, Safikhan N, Yang F, Ao Z, Warnock GL, Marzban L
Three-dimensional scaffolds reduce islet amyloid formation and enhance survival and function of cultured human islets.
Zhang Y, Jalili RB, Warnock GL, Ao Z, Marzban L, Ghahary A
Cleavage of protein kinase D after acute hypoinsulinemia prevents excessive lipoprotein lipase-mediated cardiac triglyceride accumulation.
Kim MS, Wang F, Puthanveetil P, Kewalramani G, Innis S, Marzban L, Steinberg SF, Webber TD, Kieffer TJ, Abrahani A, Rodrigues B
Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture.
Marzban L, Tomas A, Becker TC, Rosenberg L, Oberholzer J, Fraser PE, Halban PA, Verchere CB
Molecular mechanisms of islet amyloid mediated beta cell death
Principal investigators: Marzban, Lucy
Keywords: Adenoviral Transduction; Animal Studies; Beta Cell Apoptosis; Beta Cell Function; Cell Culture; Histology; Insulin; Islet Amyloid; Islet Transplantation; Type 2 Diabetes
Molecular mechanisms of islet amyloid mediated beta cell death.
Principal investigators: Marzban, Lucy
Keywords: Adenoviral Transduction; Amyloid; Beta Cell; Histology; Islet Transplantation; Type 2 Diabetes
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Surgery
- Cellular and Molecular Pharmacology
- Medicine
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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