Marc Horwitz, University of British Columbia

Research

Epstein-Barr Virus Multiple Sclerosis Mouse Models Therapeutics Arthritis Autoimmune Disease Autoimmune Diseases Basic-Clinical Research Partnerships

Latest papers

The Hippo terminal effector YAP boosts enterovirus replication in type 1 diabetes.
Nature communications · 2025
Antiviral anticoagulation.
Research and practice in thrombosis and haemostasis · 2020 · senior author
Prehistoric enemies within: The contribution of human endogenous retroviruses to neurological diseases. Meeting report: "Second International Workshop on Human Endogenous Retroviruses and Disease", Washington DC, March 13th and 14th 2017.
Multiple sclerosis and related disorders · 2017

All 4 publications

Latest funding

Alamar discovery of plasma biomarkers that distinguish dementia subtypes, inform on disease staging and predict rate of cognitive decline in Alzheimer's Disease and Related Dementias
CIHR · 2026 · Co-investigator
$1,699,389
Autoimmune Biomedical Collaborative (ABC) Annual Workshop
CIHR · 2025 · Nominated PI
$20,000
Optimizing the Humanized Mouse Models of EBV Infection: Unraveling Viral Influence on Autoimmune Development and Assessing Feasibility of EBV-Targeted Therapeutics in Optimized Humanized Mouse Models of Infection
CIHR · 2025 · Nominated PI
$1,476,450

All 11 grants and awards

4 publications.

01

The Hippo terminal effector YAP boosts enterovirus replication in type 1 diabetes.

Geravandi S, Liu H, Pahwa H, Madduri MK, Atawneh F, Miraki Feriz A, Rafizadeh S, Kruf AE, Khazaei M, Bahrami P, Gotti D, Elawour M, Elgamal RM, Grasso AM, Bund D, Lupse B, Azizi Z, Zabad O, Bouzakri K, Horwitz M, Pugliese A, Maedler K, Ardestani A

Nature communications2025

DOI: 10.1038/s41467-025-64508-6 PMID: 41053097

02

Antiviral anticoagulation.

Pryzdial ELG, Sutherland MR, Lin BH, Horwitz M

Research and practice in thrombosis and haemostasis2020Senior author

DOI: 10.1002/rth2.12406 PMID: 32685886

03

Prehistoric enemies within: The contribution of human endogenous retroviruses to neurological diseases. Meeting report: "Second International Workshop on Human Endogenous Retroviruses and Disease", Washington DC, March 13th and 14th 2017.

Kremer D, Glanzman R, Traboulsee A, Nath A, Groc L, Horwitz M, Göttle P, Perron H, Gold J, Hartung HP, Küry P

Multiple sclerosis and related disorders2017

DOI: 10.1016/j.msard.2017.05.001 PMID: 28641767

04

From bugs to brains: The microbiome in neurological health.

McKay KA, Kowalec K, Brinkman F, Finlay BB, Horwitz M, Manges AR, Osborne L, Tremlett H

Multiple sclerosis and related disorders2017

DOI: 10.1016/j.msard.2016.12.007 PMID: 28283098

Alamar discovery of plasma biomarkers that distinguish dementia subtypes, inform on disease staging and predict rate of cognitive decline in Alzheimer's Disease and Related Dementias

Co-investigatorCIHR2026Project Grant

Principal investigators: Wellington, Cheryl L

Keywords: Alzheimer'S Disease; Biomarkers; Dementia; Immunoassay

$1,699,389

Autoimmune Biomedical Collaborative (ABC) Annual Workshop

Nominated PICIHR2025Planning and Dissemination Grant - Institute Community Support

Principal investigators: Horwitz, Marc S

Keywords: Autoimmune Diseases; Basic-Clinical Research Partnerships; Common Mechanisms; Interdisciplinary Approaches; Knowledge Dissemination; Patient Advocacy; Resource Sharing; Therapeutics

$20,000

Optimizing the Humanized Mouse Models of EBV Infection: Unraveling Viral Influence on Autoimmune Development and Assessing Feasibility of EBV-Targeted Therapeutics in Optimized Humanized Mouse Models of Infection

Nominated PICIHR2025Project Grant

Principal investigators: Horwitz, Marc S

Keywords: Arthritis; Autoimmune Disease; Epstein-Barr Virus; Mouse Models; Multiple Sclerosis; Therapeutics

$1,476,450

Age-associated B cells in viral infection and autoimmune diseases

Nominated PICIHR2021Project Grant

Principal investigators: Horwitz, Marc S

Keywords: Age-Associated B Cells; Aging; B Cells; Epstein-Barr Virus; Gammaherpesviruses; Interferon-Gamma; Mouse Models; Multiple Sclerosis; Rheumatoid Arthritis

$1,128,376

Host cell-derived tissue factor as a broad-spectrum basis for viral pathology and infection

Co-investigatorCIHR2021Project Grant

Principal investigators: Pryzdial, Edward L

Keywords: Biochemistry; Blood Clotting; Envelope Virus; Tissue Factor

$1,137,645

In Vivo Modeling of EBV's role in the development of Multiple Sclerosis

Nominated PICIHR2019Project Grant

Principal investigators: Horwitz, Marc S

Keywords: Eae; Epstein-Barr Virus; Human Immunology; Interferon; Memory B Cells; Multiple Sclerosis

$918,000

Polymer-Based Manufacturing of Tolerogenic miRNA-Based Therapeutics

Co-investigatorCIHR2015Operating Grant: Priority Announcement - Transfusion Science

Principal investigators: Scott, Mark D

Keywords: Autoimmunity; Immunology; Mice; Mirna; Polymers

Polymer-Grafted Allogeneic Leukocytes and Systemic Immune Modulation

Co-investigatorCIHR2012Operating Grant

Principal investigators: Scott, Mark D

Keywords: Bioengineering; Lymphocyte; Polymer

$822,276

The development and design of anti-HIV-1 specific microbicides utilizing the display properties of Caulobacter crescentus

Nominated PICIHR2011Operating Grant

Principal investigators: Horwitz, Marc S

Keywords: Biopharmaceutical; Caulobacter; Hiv-1; Mice; Microbicide

$362,100

Development of an anti-HIV-1 specific microbicide using Caulobacter crescentus S-layer mediated display

Nominated PICIHR2009Catalyst Grant: Infection & Immunity - HIV/AIDS Res - Biomedical/Clinical Stream

Principal investigators: Horwitz, Marc S

Keywords: Bacterial Protein Display; Hiv-1; Microbicide

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Microbiology and Immunology
Medicine/Neurology
Molecular Biology and Biochemistry

Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Anthony Traboulsee

Medicine/Neurology

1 shared papers, latest 2017

Helen Tremlett

Medicine/Neurology

1 shared papers, latest 2017

Lisa Osborne

Microbiology and Immunology

1 shared papers, latest 2017

Fiona Brinkman

Molecular Biology and Biochemistry

1 shared papers, latest 2017

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Epstein-Barr Virus Dear Professor Horwitz, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The Hippo terminal effector YAP boosts enterovirus replication in type 1 diabetes." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Autoimmune Biomedical Collaborative (ABC) Annual Workshop" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]