Faculty profile
Matthew Lorincz
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Research
Latest papers
Methylome profiling of SetDB1-deficient ESCs reveals coordinated epigenetic cross-talk during pluripotency.
Stem cell reports · 2026
Post-fertilization transcription initiation in an ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2.
eLife · 2025
Conservation and divergence of canonical and non-canonical imprinting in murids.
Genome biology · 2023
Latest funding
- $990,676
Molecular characterization of the neomorphic linker histone H1-4 frame-shift mutation pathogenic for Rahman syndrome
CIHR · 2026 · Nominated PI
- $933,300
Dissecting the interplay between histone marks in directing transcription in pluripotent stem and neural precursor cells.
CIHR · 2023 · Nominated PI
- $276,000
Using PGCLCs as a model system for early germ cell development to characterize the roles of histone marks and their readers in DNA methylation homeostasis and transcriptional regulation
NSERC · 2021 · Principal investigator
8 publications.
Methylome profiling of SetDB1-deficient ESCs reveals coordinated epigenetic cross-talk during pluripotency.
Bovee NGP, Habibi E, Liu Z, Hoogland SHA, Frölich S, Diepenbroek D, Bosman KCM, Arand J, Maksakova IA, Kranenbarg AK, Walter J, Brinkman AB, Mulder KW, Jansen JH, Vermeulen M, Lorincz M, Stunnenberg HG, Marks H
Post-fertilization transcription initiation in an ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2.
Kobayashi H, Igaki T, Kumamoto S, Tanaka K, Takashima T, Nagaoka SI, Suzuki S, Hayashi M, Renfree MB, Kawahara M, Saito S, Kobayashi T, Nagashima H, Matsunari H, Nakano K, Uchikura A, Kiyonari H, Kaneko M, Imai H, Nakabayashi K, Lorincz M, Kurimoto K
Conservation and divergence of canonical and non-canonical imprinting in murids.
Richard Albert J, Kobayashi T, Inoue A, Monteagudo-Sánchez A, Kumamoto S, Takashima T, Miura A, Oikawa M, Miura F, Takada S, Hirabayashi M, Korthauer K, Kurimoto K, Greenberg MVC, Lorincz M, Kobayashi H
Epigenetic Mechanisms Governing Female and Male Germline Development in Mammals.
Shirane K, Lorincz M
Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations.
Karahan G, Chan D, Shirane K, McClatchie T, Janssen S, Baltz JM, Lorincz M, Trasler J
Transcription shapes genome-wide histone acetylation patterns.
Martin BJE, Brind'Amour J, Kuzmin A, Jensen KN, Liu ZC, Lorincz M, Howe LJ
Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo.
Richard Albert J, Au Yeung WK, Toriyama K, Kobayashi H, Hirasawa R, Brind'Amour J, Bogutz A, Sasaki H, Lorincz M
Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin.
Hiragami-Hamada K, Soeroes S, Nikolov M, Wilkins B, Kreuz S, Chen C, De La Rosa-Velázquez IA, Zenn HM, Kost N, Pohl W, Chernev A, Schwarzer D, Jenuwein T, Lorincz M, Zimmermann B, Walla PJ, Neumann H, Baubec T, Urlaub H, Fischle W
Molecular characterization of the neomorphic linker histone H1-4 frame-shift mutation pathogenic for Rahman syndrome
Principal investigators: Lorincz, Matthew C
Keywords: Chromatin; Chromatin Immunoprecipitation; Dna Methylation; Epigenetics; Genetics; Histones; Induced Pluripotent Stem Cells; Neuronal Progenitor Cells; Neurons; Rahman Syndrome
Dissecting the interplay between histone marks in directing transcription in pluripotent stem and neural precursor cells.
Principal investigators: Lorincz, Matthew C
Keywords: Chromatin; Covalent Histone Marks; Dna Methylation; Embryonic Stem Cells; Epigenetics; Genetics
Using PGCLCs as a model system for early germ cell development to characterize the roles of histone marks and their readers in DNA methylation homeostasis and transcriptional regulation
Principal investigators: Lorincz, Matthew
Keywords: dna methylation; covalent histone modification; transcriptional regulation; h3k9me3; retrotransposons; pgclcs; gametogenesis; primordial germ cells; chip-seq; rna-seq
The role of histone methylation in guiding de novo DNA methylation in the male germline
Principal investigators: Lorincz, Matthew C
Keywords: Dna Methylation; Epigenetics; Gene Regulation; Genome-Wide; Germ Cells; H3k36me2; Histone Modification; Nsd1; Spermatogenesis; Transcription
Epigenetic regulation and function of species-specific imprinted genes: testing a new hypothesis for the evolution of imprinting
Principal investigators: Lefebvre, Louis
Keywords: Crispr-Cas9 Mutagenesis; Dna Methylation; Endogenous Retroviruses; Epigenetics; Genomic Imprinting; Human Trophoblast; Mouse Models; Oocyte; Trophoblast Stem Cells
Defining the Roles of the Overgrowth Syndrome Genes NSD1, Setd2 and EZH2 in Shaping the Epigenome and Transcriptome in Early Embryonic Development
Principal investigators: Lorincz, Matthew C
Keywords: Chromatin; Ezh2; H3k36me3; Methylation; Nsd1; Overgrowth Syndromes; Polycomb; Setd2; Sotos Syndrome; Weaver Syndrome
Canadian Epigenetics, Environment and Health Research Consortium Network
Principal investigators: Hirst, Martin; Arrowsmith, Cheryl H; Bourque, Guillaume; Foster, Leonard J; Jones, Steven; Pastinen, Tomi
Keywords: Epigenomics
Genome-wide profiling and functional analysis of the covalent histone mark H3S10P in interphase mouse cells
Principal investigators: Lorincz, Matthew
Interplay between H3K9me writers, readers, DNA methylation & transcription in ESCs and PGCs
Principal investigators: Lorincz, Matthew C
Keywords: Chip-Seq; Conditional Mouse Knock-Outs; Covalent Histone Modifications; Dna Methylation; Embryonic Development; Epigenetics; Fertility; Imprinting; Primoridial Germ Cells; Whole Genome Bisulphite Sequencing
An Epigenomic Data Coordination Centre for Canada
Principal investigators: Jones, Steven
Keywords: Bioinformatics; Dna Methylation; Epigenetics; Epigenomics; Histone Modification
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Jacquetta Trasler and Matthew Lorincz: 1 shared paper
- Matthew Lorincz and Carol Chen: 1 shared paper
- Matthew Lorincz and Keegan Korthauer: 1 shared paper
- Department of Medical Genetics
- Pediatrics
- Department of Statistics
- Other
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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