Faculty profile
Natalie Strynadka
Back to facultyThis profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses and email address may be missing. Find their university profile.
Research
Latest papers
Structure-Function Relationship of the β-Hairpin of Thermus thermophilus HB27 Laccase.
International journal of molecular sciences · 2025
Characterization of novel small molecule inhibitors of estrogen receptor-activation function 2 (ER-AF2).
Breast cancer research : BCR · 2024
Automated discovery of noncovalent inhibitors of SARS-CoV-2 main protease by consensus Deep Docking of 40 billion small molecules.
Chemical science · 2021
Latest funding
- $722,926
Structure-based design of small molecule inhibitors of the transsulfuration pathway in Ewing Sarcoma.
CIHR · 2025 · Principal investigator
- $1,243,126
Reinforcing the battle at the bacterial cell wall: Structure-guided characterization and inhibition of beta-lactam antibiotic resistance signalling mechanisms
CIHR · 2023 · Nominated PI
- $100,000
COVID-19 Variant Network - Bespoke transition state analog inhibitors of SARS-CoV-2 3CL and PL proteases
CIHR · 2021 · Nominated PI
6 publications.
Structure-Function Relationship of the β-Hairpin of Thermus thermophilus HB27 Laccase.
Miranda-Zaragoza B, Huerta-Miranda GA, García-García WI, Hernández-Álvarez E, Solano-Peralta A, Lee J, Strynadka N, Miranda-Hernández M, Rodríguez-Almazán C
Characterization of novel small molecule inhibitors of estrogen receptor-activation function 2 (ER-AF2).
Foo J, Gentile F, Massah S, Morin H, Singh K, Lee J, Smith J, Ban F, LeBlanc E, Young R, Strynadka N, Lallous N, Cherkasov A
Automated discovery of noncovalent inhibitors of SARS-CoV-2 main protease by consensus Deep Docking of 40 billion small molecules.
Gentile F, Fernandez M, Ban F, Ton AT, Mslati H, Perez CF, Leblanc E, Yaacoub JC, Gleave J, Stern A, Wong B, Jean F, Strynadka N, Cherkasov A
Crystal structure of New Delhi metallo-β-lactamase reveals molecular basis for antibiotic resistance.
King D, Strynadka N
A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism.
Dresen C, Lin LY, D'Angelo I, Tocheva EI, Strynadka N, Eltis LD
Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.
Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang JX, Snieckus V, Ly LH, Converse PJ, Jacobs WR, Strynadka N, Eltis LD
Structure-based design of small molecule inhibitors of the transsulfuration pathway in Ewing Sarcoma.
Principal investigators: Cherkasov, Artem; Strynadka, Natalie C
Keywords: Cancer Metabolism; Cell Biology; High Throughput Screening; Hydrogen Sulfide; Reactive Oxygen Species; Structure-Based Drug Design; Sulfur Metabolism; Tumor Progression
Reinforcing the battle at the bacterial cell wall: Structure-guided characterization and inhibition of beta-lactam antibiotic resistance signalling mechanisms
Principal investigators: Strynadka, Natalie C
Keywords: Ai Driven Design And Docking Of Inhibitors; Bacterial Cell Wall Biosynthesis; Beta-Lactam Antibiotics And Resistance; Macromolecular Xray Crystallography; Membrane Mimetics; Membrane Protein Complexes; Membrane Spanning Enzyme Assays; Single Particle Cryo Electron Microscopy; Structure Guided Antibiotic Discovery; Transition State Inhibitors
COVID-19 Variant Network - Bespoke transition state analog inhibitors of SARS-CoV-2 3CL and PL proteases
Principal investigators: Strynadka, Natalie C
Keywords: Mechanism Based Inhiibtors; Pharmaceutical Development; Single Particle Cryoem; Structure Based Antimicrobial Discovery; Transition State Analogs; Viral Proteases; Xray Crystallography
COVID-19 Variant Supplement - Computer-aided discovery of synergistic drug combinations with Remdevisir for COVID-19 through mechanism-based drug repurposing and combinatorial organoid screening.
Principal investigators: Cherkasov, Artem; Jean, François
Keywords: Drug And Natural Product Repurposing; Enable High-Quality Data On Existing Covid-19 Treatment; Enhance Canadian Engagement In Large Scale Trials; Enhance Engagement With Middle-Income & Low-Income Countries; Evidences For Clinical & Public Health Decision Makers; Idenitfy Remdesivir Synergistic Drugs; National And International Coordination For Sharing Of Data; New Covid-19 Treatment For Interventions And Prevention; Rapid Deployment Of Existing Research Platforms; Sex As A Biological Variable
COVID-19 Variant Network - Computer-aided discovery of synergistic drug combinations with Remdevisir for COVID-19 through mechanism-based drug repurposing and combinatorial organoid screening.
Principal investigators: Cherkasov, Artem; Jean, François
Keywords: Drug And Natural Product Repurposing; Enable High-Quality Data On Existing Covid-19 Treatment; Enhance Canadian Engagement In Large Scale Trials; Enhance Engagement With Middle-Income & Low-Income Countries; Evidences For Clinical & Public Health Decision Makers; Idenitfy Remdesivir Synergistic Drugs; National And International Coordination For Sharing Of Data; New Covid-19 Treatment For Interventions And Prevention; Rapid Deployment Of Existing Research Platforms; Sex As A Biological Variable
COVID-19 Variant Supplement - Bespoke transition state analog inhibitors of SARS-CoV-2 3CL and PL proteases
Principal investigators: Strynadka, Natalie C
Keywords: Mechanism Based Inhiibtors; Pharmaceutical Development; Single Particle Cryoem; Structure Based Antimicrobial Discovery; Transition State Analogs; Viral Proteases; Xray Crystallography
Structure-guided in vitro and in situ analysis of virulence linked secretion systems in drug-resistant bacteria
Principal investigators: Strynadka, Natalie C
Keywords: Antibiotic Resistance; Atomic Structures Of Membrane Protein Complexes; Bacterial Mediated Disease; Bacterial Nanomachines; Cellular Microbiology; Cryo Electron Microscopy; Structure Based Antimicrobial Design; Xray Crystallography
Bespoke transition state analog inhibitors of SARS-CoV-2 3CL and PL proteases
Principal investigators: Strynadka, Natalie C
Keywords: Mechanism Based Inhiibtors; Pharmaceutical Development; Single Particle Cryoem; Structure Based Antimicrobial Discovery; Transition State Analogs; Viral Proteases; Xray Crystallography
Sex as a Biological Variable Supplement - Augmented Discovery of Potential Inhibitors of SARS-CoV-2 3CL Protease
Principal investigators: Cherkasov, Artem
Keywords: Biomedical Research
Augmented Discovery of Potential Inhibitors of SARS-CoV-2 3CL Protease
Principal investigators: Cherkasov, Artem
Keywords: Biomedical Research
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Artem Cherkasov and Natalie Strynadka: 2 shared papers
- Robert Young and Artem Cherkasov: 1 shared paper
- Robert Young and Natalie Strynadka: 1 shared paper
- Urologic Sciences
- Chemistry
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.