David Goodlett, University of Victoria

Research

Lipids Syphilis Treponema Pallidum Cardiolipin Diagnostics Infection Markers Lipid Remodelling Lipidomics

Latest papers

Association of Fontan Pathophysiology With Plasma Bile Acids.
JACC. Advances · 2025
Misincorporations of amino acids in p53 in human cells at artificially constructed termination codons in the presence of the aminoglycoside Gentamicin.
Frontiers in genetics · 2024
Bioinformatics Tools and Knowledgebases to Assist Generating Targeted Assays for Plasma Proteomics.
Methods in molecular biology (Clifton, N.J.) · 2023

All 7 publications

Latest funding

Diet Regulation of the Metabolic-Immune Axis
CIHR · 2026 · Co-investigator
$1,438,200
Lipidomic profiling of human and rabbit serum for development of novel tools to combat syphilis
CIHR · 2024 · Nominated PI
$100,000
The co-infection paradigm - understanding how bacteria enhance influenza virus infection.
CIHR · 2024 · Co-investigator
$986,850

All 7 grants and awards

7 publications.

01

Association of Fontan Pathophysiology With Plasma Bile Acids.

Shah AH, Surendran A, Hassan-Tash P, Turnbull CN, Johnston N, Goodlett D, Han J, Ducas RA, Tam JW, Renner E, Duhamel TA, Aliani M, Ravandi A, Krasuski RA

JACC. Advances2025

DOI: 10.1016/j.jacadv.2024.101563 PMID: 39827765

02

Misincorporations of amino acids in p53 in human cells at artificially constructed termination codons in the presence of the aminoglycoside Gentamicin.

Pawlicka K, Henek T, Uhrik L, Hernychova L, Padariya M, Faktor J, Makowiec S, Vojtesek B, Goodlett D, Hupp T, Kalathiya U

Frontiers in genetics2024

DOI: 10.3389/fgene.2024.1407375 PMID: 39563734

03

Bioinformatics Tools and Knowledgebases to Assist Generating Targeted Assays for Plasma Proteomics.

Mohammed Y, Goodlett D, Borchers CH

Methods in molecular biology (Clifton, N.J.)2023

DOI: 10.1007/978-1-0716-2978-9_32 PMID: 36781806

04

Absolute Quantitative Targeted Proteomics Assays for Plasma Proteins.

Mohammed Y, Goodlett D, Borchers CH

Methods in molecular biology (Clifton, N.J.)2023

DOI: 10.1007/978-1-0716-2978-9_27 PMID: 36781801

05

Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19.

Rocheleau GLY, Lee T, Mohammed Y, Goodlett D, Burns K, Cheng MP, Tran K, Sweet D, Marshall J, Slutsky AS, Murthy S, Singer J, Patrick DM, Du B, Peng Z, Lee TC, Boyd JH, Walley KR, Lamontagne F, Fowler R, Winston BW, Haljan G, Vinh DC, McGeer A, Maslove D, Patrigeon SP, Mann P, Donohoe K, Hernandez G, Russell JA, for ARBs CORONA I Investigators

Critical care medicine2022

DOI: 10.1097/ccm.0000000000005589 PMID: 35607951

06

Cytoplasmic switch of ARS2 isoforms promotes nonsense-mediated mRNA decay and arsenic sensitivity.

Mesa-Perez M, Hamilton PT, Miranda A, Brodie N, O'Sullivan C, Christie J, Ryan BC, Chow RL, Goodlett D, Nelson CJ, Howard PL

Nucleic acids research2022

DOI: 10.1093/nar/gkac033 PMID: 35104878

07

The emerging landscape of single-molecule protein sequencing technologies.

Alfaro JA, Bohländer P, Dai M, Filius M, Howard CJ, van Kooten XF, Ohayon S, Pomorski A, Schmid S, Aksimentiev A, Anslyn EV, Bedran G, Cao C, Chinappi M, Coyaud E, Dekker C, Dittmar G, Drachman N, Eelkema R, Goodlett D, Hentz S, Kalathiya U, Kelleher NL, Kelly RT, Kelman Z, Kim SH, Kuster B, Rodriguez-Larrea D, Lindsay S, Maglia G, Marcotte EM, Marino JP, Masselon C, Mayer M, Samaras P, Sarthak K, Sepiashvili L, Stein D, Wanunu M, Wilhelm M, Yin P, Meller A, Joo C

Nature methods2021

DOI: 10.1038/s41592-021-01143-1 PMID: 34099939

Diet Regulation of the Metabolic-Immune Axis

Co-investigatorCIHR2026Project Grant

Principal investigators: Lum, Julian J

Keywords: Chronic Lymphocytic Leukemia; Diet; Gut Microbiome; Immune Cells; Intermittent Fasting; Metabolites; Nutrition

$1,438,200

Lipidomic profiling of human and rabbit serum for development of novel tools to combat syphilis

Nominated PICIHR2024Cat Gr: STBBI Research in Canada: Beyond HIV/AIDS and Hepatitis C- Syphilis

Principal investigators: Goodlett, David R

Keywords: Cardiolipin; Diagnostics; Infection Markers; Lipid Remodelling; Lipidomics; Lipids; Mass Spectrometry; Syphilis; Treponema Pallidum; Vaccine Testing

$100,000

The co-infection paradigm - understanding how bacteria enhance influenza virus infection.

Co-investigatorCIHR2024Project Grant

Principal investigators: Goncheva, Mariya I

Keywords: Viral - Bacterial Co-Infection; Virology

$986,850

Metabolic Insights into Immune Suppression in Ovarian Cancer

Co-investigatorCIHR2023Project Grant

Principal investigators: Lum, Julian J

Keywords: 13c-Glucose Tracing; Car-T Cells; Immune Suppression/Resistance; Immunometabolism; Immunotherapy; Metabolism; Metabolomics; Ovarian Cancer

$1,101,600

Detecting dysregulated host processes during syphilis infection via multi-omics analyses of patient samples

Co-investigatorCIHR2023Op. Grant: STBBI Research in Canada: Beyond HIV/AIDS and Hepatitis C-Syphilis

Principal investigators: Cameron, Caroline E

Keywords: Correlates Of Protection; Host-Pathogen Interactions; Proteomics; Syphilis; Transcriptomics

$450,000

Microbial lipidomics

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Goodlett, David

$99,000

Proteomic and Immune Characterization of Treponema pallidum Outer Membrane Vesicles as a Promising Approach for Effective Syphilis Vaccine Development

Principal investigatorCIHR2021Catalyst Grant: STBBI Research in Canada: Beyond HIV/AIDS/Hepatitis C - General

Principal investigators: Cameron, Caroline E; Goodlett, David R; Reynolds, Lisa A

Keywords: Lipids; Outer Membrane Vesicles; Post-Translational Modifications; Proteins; Syphilis; Treponema Pallidum; Vaccine

$93,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Critical Care Medicine
Biochemistry and Microbiology
Médecine interne
Department of Medicine
Human Nutritional Sciences
Infectious Diseases/Internal Medicine
Other

Co-authors at University of Victoria, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Karen Tran

Faculty

1 shared papers, latest 2022

David Maslove

Critical Care Medicine

1 shared papers, latest 2022

Michel Aliani

Human Nutritional Sciences

1 shared papers, latest 2025

Robert Fowler

Infectious Diseases/Internal Medicine

1 shared papers, latest 2022

Francois Lamontagne

Médecine interne

1 shared papers, latest 2022

John Marshall

Critical Care Medicine

1 shared papers, latest 2022

Kevin Burns

Department of Medicine

1 shared papers, latest 2022

Srinivas Murthy

Faculty

1 shared papers, latest 2022

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Lipids Dear Professor Goodlett, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Association of Fontan Pathophysiology With Plasma Bile Acids." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Lipidomic profiling of human and rabbit serum for development of novel tools to combat syphilis" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]