Faculty profile

John Marshall

ResearcherCritical Care MedicineUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

John Marshall

Researcher

Critical Care Medicine

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
26 publications in the last five years, latest in 2026.
Principal investigator on 16 research grants (15 CIHR, 1 SSHRC), most recently in 2025.
Supervised 2 trainees who won CIHR awards, most recently in 2017.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

2,520

Citations

h-index

215

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Covid-19 Clinical Trials Global Health Network Critical Illness Platform Trial Critical Care Acute Organ Dysfunction

Latest papers

Safety of intravascular administration of umbilical-cord-derived mesenchymal stromal cells: an updated systematic review and meta-analysis.
Stem cells translational medicine · 2026
Selective Decontamination of the Digestive Tract during Ventilation in the ICU.
The New England journal of medicine · 2026
Procalcitonin to Guide 7 vs 14 Days of Antibiotics in Bloodstream Infections
JAMA Network Open · 2026

All 82 publications

Latest funding

Symposium on Corticosteroids in Critical Illness - What do we still not understand?
CIHR · 2025 · Principal investigator
$19,725
Precision medicine Adaptive Network platform Trial in Hypoxemic acutE respiratory failuRe (PANTHER)
CIHR · 2025 · Co-investigator
$2,952,135
Precision medicine Adaptive Network platform Trial in Hypoxemic acutE respiratory failuRe (PANTHER)
CIHR · 2025 · Co-investigator
$100,000

All 54 grants and awards

82 publications.

Safety of intravascular administration of umbilical-cord-derived mesenchymal stromal cells: an updated systematic review and meta-analysis.

Hum C, Poliwoda J, Lalu M, Stewart DJ, Mei SHJ, Walley KR, Marshall J, Mendelson AA, Fergusson DA, English S, Winston BW, Granton J, Dos Santos CC, Champagne J, McIntyre L

Stem cells translational medicine2026

DOI: 10.1093/stcltm/szag029 PMID: 42246109

Selective Decontamination of the Digestive Tract during Ventilation in the ICU.

SuDDICU Investigators for the Australia and New Zealand Intensive Care Society Clinical Trials Group and the Canadian Critical Care Trials Group, Cuthbertson BH, Billot L, Campbell MK, Daneman N, Davis JS, Delaney A, Devaux A, Ferguson ND, Finfer SR, Fowler R, Gordon AC, Hammond NE, Klein G, Li Q, Marshall J, Micallef S, Murthy S, Mysore J, Naik C, Patel C, Pinto R, Rose L, Seppelt IM, Venkatesh B, Young PJ, Myburgh JA, The SuDDICU Investigators for the Australia and New Zealand Intensive Care Society Clinical Trials Group and the Canadian Critical Care Trials Group

The New England journal of medicine2026

DOI: 10.1056/nejmoa2506398 PMID: 41159880

Procalcitonin to Guide 7 vs 14 Days of Antibiotics in Bloodstream Infections

Ramendra R, Wright JK, Kain KC, Kim B, Mishra H, Zhong K, Aslanian P, Carignan A, Conly J, Detsky M

JAMA Network Open20262 citations

DOI: 10.1001/jamanetworkopen.2026.20973

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections

Daneman N, Rishu A, Pinto R, Rogers BA, Shehabi Y, Parke R, Cook D, Arabi Y, Muscedere J, Reynolds S

New England Journal of Medicine2025167 citations

DOI: 10.1056/nejmoa2404991

A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline

McIntyre L, Fergusson D, McArdle T, English S, Cook DJ, Fox-Robichaud AE, Martin C, Marshall J, Pugliese M, Menon K

New England Journal of Medicine202530 citations

DOI: 10.1056/nejmoa2416761

Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial

Armstrong E, Kulikova M, Yee N, Rishu A, Muscedere J, Sibley S, Maslove D, Boyd JG, Evans G, Detsky M

Open Forum Infectious Diseases20255 citations

DOI: 10.1093/ofid/ofaf137

Coenrollment of critically ill patients in PROSPECT: characteristics and association with treatment efficacy and safety

Thabane A, Heels-Ansdell D, Zytaruk N, Johnstone J, Lauzier F, Arabi YM, Muscedere J, Clarke F, Hand L, Watpool I

Trials2025

DOI: 10.1186/s13063-025-09028-w

Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia.

Lee CH, Banoei MM, Ansari M, Cheng MP, Lamontagne F, Griesdale D, Lasry DE, Demir K, Dhingra V, Tran KC, Lee T, Burns K, Sweet D, Marshall J, Slutsky A, Murthy S, Singer J, Patrick DM, Lee TC, Boyd JH, Walley KR, Fowler R, Haljan G, Vinh DC, Mcgeer A, Maslove D, Mann P, Donohoe K, Hernandez G, Rocheleau G, Trahtemberg U, Kumar A, Lou M, Dos Santos C, Baker A, Russell JA, Winston BW, *ARBs CORONA I. Investigators

Critical care (London, England)2024

DOI: 10.1186/s13054-024-04843-0 PMID: 38414082

Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis.

Baillie JK, Angus D, Burnham K, Calandra T, Calfee C, Gutteridge A, Hacohen N, Khatri P, Langley R, Ma'ayan A, Marshall J, Maslove D, Prescott HC, Rowan K, Scicluna BP, Seymour C, Shankar-Hari M, Shapiro N, Joost Wiersinga W, Singer M, Randolph AG

Intensive care medicine2024

DOI: 10.1007/s00134-024-07665-4 PMID: 39432104

Sodium-glucose co-transporter-2 inhibitors for hospitalised patients with COVID-19: a prospective meta-analysis of randomised trials.

Vale C, Godolphin PJ, Fisher D, Horby PW, Kosiborod MN, Hochman JS, Webster K, Higgins JPT, Althouse AD, Berwanger O, Furtado RHM, Gasparyan SB, Haynes R, Koch GG, Landray M, Leifer E, Marshall J, Murthy S, Neal MD, Staplin N, Diaz J, Sterne JAC, Shankar-Hari M, WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group

The lancet. Diabetes & endocrinology2024

DOI: 10.1016/s2213-8587(24)00219-5 PMID: 39250923

Symposium on Corticosteroids in Critical Illness - What do we still not understand?

Principal investigatorCIHR2025Planning and Dissemination Grant - Institute Community Support

Principal investigators: Teja, Bijan J; Marshall, John C; Mazer, David

Keywords: Adaptive Platform Trial; Corticosteroids; Critical Care

$19,725

Precision medicine Adaptive Network platform Trial in Hypoxemic acutE respiratory failuRe (PANTHER)

Co-investigatorCIHR2025Project Grant

Principal investigators: Ferguson, Niall D; Calfee, Carolyn; McAuley, Danny

Keywords: Acute Hypoxemic Respiratory Failure; Platform Trial; Precision Medicine

$2,952,135

Precision medicine Adaptive Network platform Trial in Hypoxemic acutE respiratory failuRe (PANTHER)

Co-investigatorCIHR2025Project Grant - Priority Announcement: Respiratory health across the lifespan

Principal investigators: Ferguson, Niall D; Calfee, Carolyn; McAuley, Danny

Keywords: Acute Hypoxemic Respiratory Failure; Platform Trial; Precision Medicine

$100,000

Adaptive platform trials in pandemics: Evaluating COVID-19 case studies and developing guidelines for future health emergencies

Co-investigatorCIHR2023Project Grant - PA: Pandemic Preparedness and Health Emergencies Research

Principal investigators: Hosseini, Benita; Pinto, Andrew D

Keywords: Adaptive Platform Trials (Apts); Comparative Case Study; Guidelines Development; Pandemic Preparedness

$100,000

The Randomized Embedded Multifactorial Adaptive Platform Trial in Community-Acquired Pneumonia (REMAP-CAP): Enshrining a Global Pandemic Research Response to COVID-19 and Beyond

Nominated PICIHR2022Operating Grant: Clinical Trials Projects - Indirect Costs

Principal investigators: Marshall, John C; Dalziel, Sandra; Kho, Michelle E; Lamontagne, Francois; Leligdowicz, Aleksandra; Murthy, Srinivas; Park, Jay; Smith, Kathleen F

Keywords: Acute Organ Dysfunction; Covid-19; Critical Illness; Global Health; Hemodynamic Management; Platform Trial; Research Collaboration; Ventilatory Support

$883,029

Canadian Critical Care Trials Group COVID-19 Response: defining critical care capacity in Canada; testing treatments through large-scale adaptive clinical trials; & establishing the evidence base to inform clinical and health system management decisions

Principal investigatorCIHR2022Operating Grant: CNCCTN Extension - Indirect Costs

Principal investigators: Fowler, Robert A; Adhikari, Neill K; Archambault, Patrick; Bagshaw, Sean M; Binnie, Alexandra; Chasse, Michael; Cook, Deborah J; Daneman, Nick; Fiest, Kirsten M; Fox-Robichaud, Alison E; Goligher, Ewan C; Herridge, Margaret S; Kho, Michelle E; Lamontagne, Francois; Lawler, Patrick R; Lee, Todd C; Marshall, John C; McDonald, Emily G; McNally, James D; Meade, Maureen O; Mehta, Sangeeta; Menon, Kusum; Murthy, Srinivas; O'Hearn, Katharine J; Piquette, Dominique; Rochwerg, Bram N; Russell, James A; Tsang, Jennifer L; Turgeon, Alexis F; Wollny, Krista; Yada, Nicole; Zarychanski, Ryan

Keywords: Clinical Trials; Covid-19; Network

$1,000,000

BALANCE+: A Platform Trial for Gram Negative Bloodstream Infections

Co-investigatorCIHR2022Operating Grant: Clinical Trials Projects - Indirect Costs

Principal investigators: Daneman, Nick; Murthy, Srinivas; Yamamura, Deborah L; Fowler, Robert A; Johnstone, Jennie; Lee, Todd C; MacFadden, Derek R; McDonald, Emily G; Paterson, David L; Rogers, Benjamin A; Yahav, Dafna

Keywords: Adaptive Platform Trial; Antibiotic De-Escalation; Antibiotic Step-Down; Antimicrobial Resistance; Bloodstream Infection; Central Venous Catheter Infection; Gram Negative Bacteremia; Randomized Controlled Trial

$729,947

The Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation (CLEAN Wound) Trial

Co-investigatorCIHR2022Operating Grant: Clinical Trials Projects - Indirect Costs

Principal investigators: Karanicolas, Paul J; Abou Khalil, Jad; Smith, David E; Tsang, Melanie E; Mason, Stephanie

Keywords: Adaptive Trial Design; Innovative Clinical Trials; Intraoperative Interventions; Perioperative Care; Pragmatic Trials; Surgery

$687,538

Canadian ADAptive Platform Trial of COVID-19 Therapeutics in Community Settings (Can-ADAPT COVID)

Co-investigatorCIHR2022Operating Grant: COVID-19 Outpatient Therapeutic Studies

Principal investigators: Pinto, Andrew D; Keynan, Yoav; Greiver, Michelle; Jüni, Peter; Lee, Todd C; McDonald, Emily G; Murthy, Srinivas; Selby, Peter L

Keywords: Adaptive Platform Trial; Covid-19; Nirmatrelvir; Out-Patient; Sars-Cov-2; Therapeutics

$5,000,000

The Randomized Embedded Multifactorial Adaptive Platform Trial in Community-Acquired Pneumonia (REMAP-CAP): Enshrining a Global Pandemic Research Response to COVID-19 and Beyond

Nominated PICIHR2022Operating Grant: Clinical Trials Projects - CRPPHE

Principal investigators: Marshall, John C; Dalziel, Sandra; Kho, Michelle E; Lamontagne, Francois; Leligdowicz, Aleksandra; Murthy, Srinivas; Park, Jay; Smith, Kathleen F

Keywords: Acute Organ Dysfunction; Covid-19; Critical Illness; Global Health; Hemodynamic Management; Platform Trial; Research Collaboration; Ventilatory Support

$3,532,110

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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John Marshall

Research

Latest papers

Latest funding

Safety of intravascular administration of umbilical-cord-derived mesenchymal stromal cells: an updated systematic review and meta-analysis.

Selective Decontamination of the Digestive Tract during Ventilation in the ICU.

Procalcitonin to Guide 7 vs 14 Days of Antibiotics in Bloodstream Infections

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections

A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline

Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial

Coenrollment of critically ill patients in PROSPECT: characteristics and association with treatment efficacy and safety

Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia.

Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis.

Sodium-glucose co-transporter-2 inhibitors for hospitalised patients with COVID-19: a prospective meta-analysis of randomised trials.

Frequent collaborators

Deborah Cook

Lauralyn McIntyre

John Muscedere

Srinivas Murthy

Diane Heels-Ansdell

Francois Lamontagne

Ryan Zarychanski

Jennifer Tsang

Shane English

Erick Duan

Anand Kumar

Nick Daneman

Bram Rochwerg

Jennie Johnstone

Lehana Thabane

Alison Fox-Robichaud

Robert Fowler

Claudio Martin

Ian Ball

Peter Dodek

Joanna Dionne

Timothy A Karachi

Sangeeta Mehta

David Maslove

John Granton

Monica Taljaard

François Lauzier

Manoj Lalu

Kednapa Thavorn

John Marshall

Raphael Saginur

Steven Hawken

Karen Tran

Daniel Niven

Alexandra Binnie

Anand Kumar

Michael Detsky

Ruxandra Pinto

Bryan Coburn

John Conly