Faculty profile
Frank Schweizer
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Research
Latest papers
Development of polymyxin- and aminoglycoside-based outer membrane permeabilizers: a review.
Frontiers in microbiology · 2025 · senior author
Amphiphilic nebramine analogs synergize with β-lactam/β-lactamase inhibitor combinations, including cefepime-taniborbactam and meropenem-xeruborbactam against metallo-β-lactamase-carrying Pseudomonas aeruginosa.
RSC medicinal chemistry · 2025 · senior author
Investigating the adjuvant activity of the proline-rich antimicrobial lipopeptide C12-PRP against antimicrobial-resistant veterinary bacterial isolates.
Journal of global antimicrobial resistance · 2025
Latest funding
- $43,000
Bioorganic chemistry of polybasic amphiphiles (PAs): Disarming bacterial defense mechanisms in Gram-negative bacteria (GNB)
NSERC · 2024 · Principal investigator
- $58,425
Purification System for Polybasic Amphiphiles (PAs)
NSERC · 2020 · Principal investigator
- $654,075
Rescuing beta-lactam antibiotic/beta-lactamase inhibitor combinations from resistance against multidrug-resistant Gram-negative pathogens
CIHR · 2020 · Nominated PI
116 publications.
Development of polymyxin- and aminoglycoside-based outer membrane permeabilizers: a review.
Ramirez DM, Schweizer F
Amphiphilic nebramine analogs synergize with β-lactam/β-lactamase inhibitor combinations, including cefepime-taniborbactam and meropenem-xeruborbactam against metallo-β-lactamase-carrying Pseudomonas aeruginosa.
Lozeau C, Ramirez D, Ramirez D, Kumar G, Arora R, Zhanel G, Arthur G, Schweizer F
Investigating the adjuvant activity of the proline-rich antimicrobial lipopeptide C12-PRP against antimicrobial-resistant veterinary bacterial isolates.
Deo S, Sharoze A, Esenbekova M, White D, Schweizer F, Mani RK, Gorityala BK, Kumar A
Structure-Activity and Cationic Amphiphilic Drug-like Behavior of Aromatic Triamino Glycosylated Antitumor Ether Lipids with Cytotoxicity in 2D and 3D Models.
Arora R, Crooks SK, Rodriguez MC, Arthur G, Nachtigal MW, Schweizer F
Gram-negative pathogens from Canadian hospitals: 17 years of results from the CANWARD study (2007-23).
Zhanel GG, Baxter MR, Lagacé-Wiens P, Walkty A, Fuller J, Davidson RJ, Blondeau J, Poutanen S, Lavallée C, Mataseje L, Golding G, Schweizer F, Bay D, Denisuik A, Li J, Karlowsky JA, Adam HJ
Gram-positive pathogens from Canadian hospitals: 17 years of results from the CANWARD study (2007-23).
Zhanel GG, Baxter MR, Golden AR, Lagacé-Wiens P, Walkty A, Fuller J, Davidson RJ, Blondeau J, Poutanen S, Lavallée C, McCracken M, Golding G, Schweizer F, Bay D, Karlowsky JA, Adam HJ
Modulating polybasic character of galactose-based glycosylated antitumor ether lipids for enhanced cytotoxic response.
Arora R, Mukherjee A, Arthur G, Nachtigal MW, Schweizer F
Noncytotoxic polymyxin derivatives enhance antibiotic action against multidrug-resistant Gram-negative bacteria.
Ramirez D, Ramirez DM, Arora R, Arthur G, Schweizer F
Cefepime–Taniborbactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination
Zhanel GG, Mansour C, Mikolayanko S, Lawrence CK, Zelenitsky S, Ramirez D, Schweizer F, Bay D, Adam H, Lagacé-Wiens P
Enhancing outer membrane permeability of tetracycline antibiotics in P. aeruginosa using TOB-CIP conjugates.
Dhiman S, Ramirez D, Arora R, Arthur G, Schweizer F
Bioorganic chemistry of polybasic amphiphiles (PAs): Disarming bacterial defense mechanisms in Gram-negative bacteria (GNB)
Principal investigators: Schweizer, Frank
Keywords: bioorganic chemistry; chemical biology; antimicrobial resistance; gram-negative bacteria; antibiotic potentiators (adjuvants); aminoglycosides; antimicrobial peptides; glycopeptides; cationic amphiphiles; glycosylation
Purification System for Polybasic Amphiphiles (PAs)
Principal investigators: Schweizer, Frank
Rescuing beta-lactam antibiotic/beta-lactamase inhibitor combinations from resistance against multidrug-resistant Gram-negative pathogens
Principal investigators: Schweizer, Frank
Keywords: Adjuvants; Antibiotics; Bacterial Resistance; Drug Discovery; Gram-Negative Pathogens
Rescuing beta-lactam antibiotic/beta-lactamase inhibitor combinations from resistance against multidrug-resistant Gram-negative pathogens
Principal investigators: Schweizer, Frank
Keywords: Antibiotics; Antimicrobial Chemotherapy; Bacterial Resistance; Drug Development; Gram-Negative Bacteria
Bioorganic chemistry of polybasic amphiphiles (PAs): Disarming bacterial defense mechanisms in Gram-negative bacteria (GNB)
Principal investigators: Schweizer, Frank
Preclinical studies on aminoglycoside-derived antibiotic adjuvants (AGDAAs)
Principal investigators: Schweizer, Frank
Keywords: Acinetobacter Baumannii; Aminoglycoside Antibiotics; Antimicrobial Resistance; Drug Discovery; Enterobacteriaceae; Gram-Negative Bacteria; Infections; Medicinal Chemistry; Pseudomans Aeruginosa
Synthetic, structural and biological studies on glycosylated amphiphilic polyproline II helices
Principal investigators: Schweizer, Frank
Development of aminoglycoside antimicrobials with novel or combined modes of action
Principal investigators: Schweizer, Frank
Keywords: Aminoglycosides; Antibacterials; Drug Discovery; Resistance
Optimization and preclinical studies on amphiphilic aminoglycoside antimicrobials (AAAs)
Principal investigators: Schweizer, Frank
Keywords: Aminoglycosides; Antibiotics; Cationic Amphiphiles; Drug Discovery; Medicinal Chemistry
Characterization of PEGylated DispersinB
Principal investigators: Schweizer, Frank
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Ayush Kumar and Frank Schweizer: 9 shared papers
- Neal Irfan and Frank Schweizer: 3 shared papers
- Neeloffer Mookherjee and Frank Schweizer: 3 shared papers
- Frank Schweizer and Susan Poutanen: 2 shared papers
- Lionel Mandell and Neal Irfan: 1 shared paper
- Lionel Mandell and Frank Schweizer: 1 shared paper
- Neeloffer Mookherjee and Thomas Klonisch: 1 shared paper
- Thomas Klonisch and Frank Schweizer: 1 shared paper
- Medicine
- Chemistry and Biochemistry
- Microbiology
- Internal Medicine/Immunology
- Department of Laboratory Medicine and Pathobiology
- Human Anatomy & Cell Science
Co-authors at University of Manitoba, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Ayush Kumar
Microbiology
9 shared papers, latest 2025
Neal Irfan
Medicine
3 shared papers, latest 2024
Neeloffer Mookherjee
Internal Medicine/Immunology
3 shared papers, latest 2015
Susan Poutanen
Department of Laboratory Medicine and Pathobiology
2 shared papers, latest 2025
Lionel Mandell
Medicine
1 shared papers, latest 2021
Thomas Klonisch
Human Anatomy & Cell Science
1 shared papers, latest 2016
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